Guillain-Barré Syndrome Associated with SARS-CoV-2 Infection: A Case Report

Abstract

A 56-year-old man was referred to the emergency department for the subacute onset of and weakness in the lower extremities, paraesthesia and pain. He was diagnosed with SARS-CoV-2 pneumonia and then, he received the necessary treatment according to national protocol. Radiographic, laboratory, and electroneurographic findings indicated an acute polyradiculoneuritis with prominent demyelination and suggesting the diagnosis of Guillain-Barr syndrome associated with COVID-19 infection.

Consider differentials before diagnosing COVID-19 associated polyradiculitis

“…1 However, a few days later he developed subacute onset lower limb weakness, paresthesias, and pain progressing to flaccid paraparesis within 12 days. 1 Work-up revealed Guillain-Barre syndrome (GBS), subtype acute, inflammatory, demyelinating neuropathy (AIDP) and he partially profited from immunoglobulins. The study is appealing but raises concerns and comments.…”

“…We read with interest the article by Darvishi et al about a 56 years old male with mild COVID-19 manifesting with fever, chills, headache, myalgia, coughing, diarrhoea, and fatigue since 5 days prior to quarantine. 1 Upon administration of the standard anti-COVID-19 therapy according to the national guidelines he recovered almost completely within 2 weeks. 1 However, a few days later he developed subacute onset lower limb weakness, paresthesias, and pain progressing to flaccid paraparesis within 12 days.…”

“…1 Upon administration of the standard anti-COVID-19 therapy according to the national guidelines he recovered almost completely within 2 weeks. 1 However, a few days later he developed subacute onset lower limb weakness, paresthesias, and pain progressing to flaccid paraparesis within 12 days. 1 Work-up revealed Guillain-Barre syndrome (GBS), subtype acute, inflammatory, demyelinating neuropathy (AIDP) and he partially profited from immunoglobulins.…”