Guillain-Barré syndrome associated with Campylobacter infection

Kuroki, Shigekazu; Haruta, T; Yoshioka, Mieko; Kobayashi, Yutaka; Nukina, Masafumi; Nakanishi, Hisao

doi:10.1097/00006454-199102000-00014

Cited by 66 publications

(39 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While patients with preceding C. jejuni infection manifest a significantly more severe form of GBS, cases with good recovery such as in our patient have also been reported [20]. [5,10,21]. Recently, Yuki et al [22,26] have revealed that the lipopolysaccharide from C. jejuni…”

Section: Discussionsupporting

confidence: 63%

Guillain-Barré syndrome associated with IgM anti-GM1 antibody followingCampylobacter jejuni enteritis

et al. 1994

View full text Add to dashboard Cite

We report a 4-year-old girl diagnosed as having Guillain-Barré syndrome after infection by Penner serotype 19 of Campylobacter jejuni. The patient had the HLA-B35 antigen. Neurological examination revealed distal-dominant weakness and intact sensation. Serial electrophysiological studies indicated that the predominant process was axonal degeneration involving motor nerves. An enzyme-linked immunosorbent assay revealed the presence of high titres of serum IgM antibodies to gangliosides GM1 and GM2. The IgM auto-antibody titres decreased concurrently with the clinical course of the illness and no switching from IgM to IgG secretion took place.

show abstract

Section: Discussionsupporting

confidence: 63%

Guillain-Barré syndrome associated with IgM anti-GM1 antibody followingCampylobacter jejuni enteritis

et al. 1994

View full text Add to dashboard Cite

show abstract

“…27 C jejuni strains of Penner types 1, 2, 4, and 5-1, originating from the serogrouping scheme of Penner and Hennessy, 28 were used as antigens. As described previously, 11 with this method, positive serum antibody titers are IgA Ն 1:80, IgG Ն 1:320, IgM Ն 1:80.…”

Section: Elisa For Antibodies To C Jejunimentioning

confidence: 99%

Anti-GalNAc-GD1a antibody-associated Guillain-Barré syndrome with a predominantly distal weakness without cranial nerve impairment and sensory disturbance

et al. 1999

Self Cite

View full text Add to dashboard Cite

The serum antibodies to N‐acetylgalactosaminyl GD1a (GalNAc‐GD1a) and other gangliosides as well as to Campylobacter jejuni were determined in 147 patients with Guillain‐Barré syndrome (GBS). We found a distinctive clinical pattern in patients with anti‐GalNAc‐GD1a antibodies compared with those without the antibodies, that is, lack of cranial nerve involvement (87% versus 38%), distal‐dominant weakness (80% versus 25%), and no sensory disturbance (73% versus 22%). The frequency of distal‐dominant weakness was significantly higher in patients with both C jejuni infection and anti‐GalNAc‐GD1a positivity (100%) than in C jejuni–negative/anti‐GalNAc‐GD1a–positive (25%), C jejuni–positive/anti‐GalNAc‐GD1a–negative (32%) and C jejuni–negative/anti‐GalNAc‐GD1a–negative patients (20%). Lack of cranial nerve involvement and sensory disturbance were found in most C jejuni–positive/anti‐GalNAc‐GD1a–positive and C jejuni–negative/anti‐GalNAc‐GD1a–positive patients, but not in C jejuni–positive/anti‐GalNAc‐GD1a–negative and C jejuni–negative/anti‐GalNAc‐GD1a–negative patients. Although the anti‐GM1–positive/anti‐GalNAc‐GD1a–negative patients mostly (75%) lacked cranial nerve involvement, distal‐dominant weakness (38%) and lack of sensory disturbance (13%) were infrequent. These results may indicate that (1) the combination of C jejuni infection and anti‐GalNAc‐GD1a antibodies, but not anti‐GalNAc‐GD1a, anti‐GM1, or C jejuni infection alone, is associated with a predominantly distal weakness, (2) the presence of anti‐GalNAc‐GD1a, rather than C jejuni infection or anti‐GM1 antibody, is associated with a lack of sensory disturbance, (3) both anti‐GalNAc‐GD1a and anti‐GM1 antibodies are independently associated with a lack of cranial nerve impairment. Ann Neurol 1999;45:758–768

show abstract

“…While the disease is most often self-limiting (2 to 7 days), individuals suffering from severe campylobacteriosis can be treated with erythromycin or ciprofloxacin. Certain strains of C. jejuni have been implicated as an antecedent to the development of GuillainBarré syndrome or acute postinfectious polyneuritis (9,18,30,38). Guillain-Barré syndrome is the most common cause of acute neuromuscular paralysis (9).…”

mentioning

confidence: 99%

Campylobacter jejuni Strains Compete for Colonization in Broiler Chicks

Konkel

Christensen

Dhillon

et al. 2007

Appl Environ Microbiol

View full text Add to dashboard Cite

Campylobacter jejuni isolates possess multiple adhesive proteins termed adhesins, which promote the organism's attachment to epithelial cells. Based on the proposal that one or more adhesins are shared among C. jejuni isolates, we hypothesized that C. jejuni strains would compete for intestinal and cecal colonization in broiler chicks. To test this hypothesis, we selected two C. jejuni strains with unique SmaI pulsed-field gel electrophoresis macrorestriction profiles and generated one nalidixic acid-resistant strain (the F38011 Nal r strain) and one streptomycin-resistant strain (the 02-833L Str r strain). In vitro binding assays revealed that the C. jejuni F38011 Nal r and 02-833L Str r strains adhered to LMH chicken hepatocellular carcinoma epithelial cells and that neither strain influenced the binding potential of the other strain at low inoculation doses. However, an increase in the dose of the C. jejuni 02-833L Str r strain relative to that of the C. jejuni F38011 Nal r strain competitively inhibited the binding of the C. jejuni F38011 Nal r strain to LMH cells in a dose-dependent fashion. Similarly, the C. jejuni 02-833L Str r strain was found to significantly reduce the efficiency of intestinal and cecal colonization by the C. jejuni F38011 Nal r strain in broiler chickens. Based on the number of bacteria recovered from the ceca, the maximum number of bacteria that can colonize the digestive tracts of chickens may be limited by host constraints. Collectively, these data support the hypothesis that C. jejuni strains compete for colonization in chicks and suggest that it may be possible to design novel intervention strategies for reducing the level at which C. jejuni colonizes the cecum.

show abstract

Guillain-Barré syndrome associated with Campylobacter infection

Cited by 66 publications

References 0 publications

Guillain-Barré syndrome associated with IgM anti-GM1 antibody followingCampylobacter jejuni enteritis

Guillain-Barré syndrome associated with IgM anti-GM1 antibody followingCampylobacter jejuni enteritis

Anti-GalNAc-GD1a antibody-associated Guillain-Barré syndrome with a predominantly distal weakness without cranial nerve impairment and sensory disturbance

Campylobacter jejuni Strains Compete for Colonization in Broiler Chicks

Contact Info

Product

Resources

About