Guillain-Barré syndrome as a complication of SARS-CoV-2 infection

Abstract

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Guillain–Barré syndrome associated with SARS‐CoV‐2 infection. A systematic review

“…A total of 18 patients reported in 14 papers [12][13][14][15][16][17][18][19][20][21][22][23][24][25] were included in this review. The 14 selected papers consisted of 13 case reports and one series.…”

“…Table 4 shows the diagnostic ancillary tests, outcome and treatment. Fourteen cases were from Europe [12,[16][17][18][19][20][22][23][24][25], one from the USA [13], one from China [14], one from Iran [15] and one from Morocco [21]. Ten patients were males whilst eight were females.…”

“…In three cases, the normal control values used for nerve conduction studies were reported and the electrophysiological subtype was revised: in two patients an acute inflammatory demyelinating polyneuropathy (AIDP) subtype was confirmed as reported by the authors, whilst in another an AIDP subtype (not specified by the authors) was defined. [16] Neurology: Neuroimmunology and Neuroinflammation Italy Case report 5 Camdessanche et al, 2020 [17] Revue Neurologique France Case report 5 Padroni et al, 2020 [18] Journal of Neurology Italy Case report 5 El Otmani et al, 2020 [19] Revue Neurologique Morocco Case report 5 Coen et al, 2020 [20] Brain, Behavior, and Immunity Switzerland Case report 5 Gal an et al, 2020 [21] Neurolog ıa Spain Case report 5 Marta-Enguita et al, 2020 [22] Neurolog ıa Spain Case report 5 Scheidl et al, 2020 [23] Journal of the Peripheral Nervous System Germany Case report 5 Ottaviani et al, 2020 [24] Neurological Sciences Italy Case report 5 Juliao Caamaño et al, 2020 [25] Journal of Clinical Neuroscience Spain Case report 5 The most frequent electrophysiological subtype was AIDP (10 patients), followed acute motor and sensory axonal neuropathy (four patients) and acute motor axonal neuropathy found in one patient. CSF was examined in all except four of the patients.…”

Neurological Complications of COVID-19: A Systematic Review of Literature

“…GBS occurred in 5/1200 (0.4%) patients with COVID-19 in one of the studies [13]. There were six other case report of GBS, one Miller Fisher syndrome, and two polyneuritis cranialis [14,[24][25][26][27][28][29][30]. Interestingly, neurotropism of human coronaviruses has been suggested by in vitro and in vivo studies that showed that certain strains of the viruses could persist in the human CNS by targeting oligodendrocytic and neuroglial cell lines [41].…”

“…Thirty-one patients experienced a cerebrovascular complication, with 27 ischemic strokes [11,[19][20][21][22][23], 3 hemorrhagic strokes [11,15,23] and 1 cerebral venous sinus thrombosis [11]. There were 15 patients with GBS [13,14,[24][25][26][27][28][29][30] or its variants, 6 reported as encephalitis [12,18,[31][32][33], one with seizures [34], one with acute hemorrhagic necrotizing encephalopathy [16] one reported as transverse myelitis [35], and one reported as ADEM [36]. Nine of these cases were reported as fatal.…”