Guillain-Barre Syndrome and its Variants: Clinical Course and Prognostic Factors

Bölükbaşı, Fatih Han; Ersen, Gülsün Ersen; Gündüz, Ayşegül; Karaali-Savrun, Feray; Yazici, Sinem; Uzun, Nurten; Akalın, Mehmet Ali; Kızıltan, Meral E.

doi:10.5152/npa.2017.18091

Cited by 6 publications

(8 citation statements)

References 19 publications

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“…Comparing our findings with other studies conducted in Turkey, one study 17 reported an average length of stay in the rehabilitation clinic as 33.5 ± 4.9 days (range: 4-77 days), while another study 18 reported a longer duration of 86.4 ± 13.2 days. The time from disease onset to admission to the rehabilitation clinic for adult patients in our study was 21.29 ± 12 days, which aligns with the existing literature 17 - 19 .…”

Section: Discussionsupporting

confidence: 91%

Three-year follow-up outcomes of adult patients with Guillain-Barré Syndrome after rehabilitation

Uz,

Karaahmet

2023

Mal. Med. J

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Background Guillain-Barré syndrome (GBS), the most common cause of acute paralytic neuropathy, covers a number of recognizably different variants. We aimed to evaluate the clinical characteristics of the patients with GBS and the outcome results of the patients after rehabilitation.Methods We enrolled 24 adult patients with GBS and evaluated their demographic characteristics, signs, complications, functional levels, and residual symptoms at admission, discharge, and during the 1st and 3rd-year follow-up visits. Functional Independence Scale (FIM), Functional Ambulation Scale (FAS), Hughes functional grading scale, Six-Minute Walking Test (6MWT), and Fatigue Severity Scale (FSS) were used for patient evaluation.Results In this study, patients with a mean age of 47.29 ± 16.2 years (40% female) were hospitalized for an average of 28.91 ± 25.6 days. The predominant symptoms experienced by these patients were fatigue (100%), neuropathic pain (70.8%), joint pain (54.2%), and autonomic dysfunction (50%). Significant changes were observed in FIM, Hughes functional grading scale, FAS, 6MWT, and MRC score at admission, discharge, and 1st/3rd-year follow-ups (p=0.000, p=0.000, p=0.000, p=0.001, p=0.000, respectively). Fatigue and Hughes score increased significantly with age (p=0.019, r=0.475; p=0.041, r=0.419, respectively). Negative correlations were found between age and FAS, 6MWT, and MRC score at 1st-year follow-up (p=0.025, r=-0.456; p=0.027, r=-0.450; p=0.008, r=-0.528). FSS was above 4 before admission and in 53.1% at 3rd-year follow-up, correlating negatively with 6MWT and MRC sum score. GBS clinical types showed no significant differences. ConclusionRehabilitation improves functional improvement in GBS patients, with long-term benefits observed. However, residual symptoms such as fatigue and neuropathic pain may persist despite functional improvement. These findings highlight the importance of incorporating rehabilitation into the management of GBS and addressing residual symptoms to improve patient outcomes.

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Section: Discussionsupporting

confidence: 91%

Three-year follow-up outcomes of adult patients with Guillain-Barré Syndrome after rehabilitation

Uz,

Karaahmet

2023

Mal. Med. J

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“…[7][8][9] Studies from Turkey that were conducted in western regions demonstrated that AIDP was also the most frequent type of GBS. 18,20 Compared to these reports, axonal subtypes were more common in our study results. Our study, to the best of our knowledge, is the first study investigated the prevalence of GBS subtypes in an Eastern region of Turkey, but our results are consistent with a previous study from the same region that found higher rates of AMAN subtypes in their study population that included pediatric patients mostly.…”

Section: Discussioncontrasting

confidence: 76%

“…The spring was the most common season the patients presented as reported in a recent study from western region of Turkey but the rate of onset during the fall in our study was much more common than this report. 18 Overall, these variabilities in subtypes, type of infection and onset of season might be due to epidemiological, and geographical differences between western and eastern regions of the country.…”

Section: Discussionmentioning

confidence: 99%

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Clinical subtypes, seasonality, and short-term prognosis of Guillain-Barré syndrome in an Eastern city of Turkey

Kiraz¹,

Yılgör²,

Milanlıoğlu³

et al. 2022

NeuroAsia

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Background & Objective: This study aimed to analyze the frequency Guillain-Barré syndrome (GBS) subtypes and their relationship with clinical characteristics, seasonal variations and early prognosis in Van City, Turkey. Methods: Patients with GBS who were admitted between January 2007 and December 2017 and diagnosed with acute inflammatory demyelinating neuropathy (AIDP), acute motor axonal neuropathy (AMAN) or acute motor sensory axonal neuropathy (AMSAN) were reviewed. Demographics, season of clinical onset, history and type of preceding infection, the Hughes Disability Score (HDS) at admission and discharge were recorded. Results: Of a total 100 patients, 51% was diagnosed with AIDP, 25% with AMAN and the remaining 24% with AMSAN subtype. The most common seasonal onset was during the spring (34%), followed by the fall (30%). The history of gastroenteritis (GE) was present in 26% of the patients and these patients were more likely to have AMAN and AMSAN subtypes. HDS on admission and at discharge were significantly higher in patients with AMAN and AMSAN compared to those with AIDP (p=0.003 and p<0.001, respectively). The most important predictor of poor outcome at discharge was HDS on admission explaining between 50% and 80% of the total variance. Conclusion: There is a high prevalence of AMAN and AMSAN subtypes in Eastern region of Turkey. The history of GE, which is also commonly found in patients with GBS in this region, is more likely detected in patients with AMAN and AMSAN subtypes. Finally, clinical severity on admission is the most important contributor to clinical outcome at discharge.

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“…В отечественной и зарубежной литературе большое внимание уделено вопросу восстановления после СГБ [9][10][11][12][13][14][15][16][17][18]. Доказанными прогностически неблагоприятными факторами восстановления являются: возраст старше 60 лет, предшествующая развитию неврологической симптоматики диарея, быстрое прогрессирование заболевания в фазу нарастания симптоматики (фульминантное развитие до плегии в первые 7 сут), выраженность двигательных нарушений в остром периоде, необходимость в искусственной вентиляции легких, наличие антител к ганглиозидам периферических нервов, а также аксональная форма заболевания [19][20][21][22][23][24][25].…”

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Specificity of recovery in acute motor axonal neuropathy with conduction blocks on the example of two clinical cases

Grishina¹,

Супонева²

2020

Neuromuscular Diseases

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Introduction. The heterogeneity of the forms and severity of Guillain-Barre syndrome explains the variability of recovery: from rapid and complete (in most cases) to slow with the development of persistent residual deficiency (rarely). It is unclear how effective the Erasmus Guillain–Barre syndrome Outcome Scores and its modified version are for different forms of the disease.The aim of the study – to demonstrate the features of recovery in acute motor axonal neuropathy with conduction blocks on the example of 2 clinical cases; to show the possibilities of Erasmus Guillain–Barre syndrome Outcome Scores and its modified version in predicting recovery in this form of the disease.Materials and methods. Data from 2 patients with acute motor axonal neuropathy with motor conduction blocks were retrospectively analyzed. Calculation of the score and assessment of the prognosis of walking recovery by 6 months from the onset of the disease were performed using the online calculator International Guillain-Barre syndrome Outcome Study Prognosis tool in the acute period.Results. In both patients, the forecast of recovery of walking by half a year from the onset of the disease on the Erasmus Guillain–Barre syndrome Outcome Scores and modified Erasmus Guillain–Barre syndrome Outcome Scores scales in the acute period was erroneous. In the first case, the total score on the Erasmus Guillain–Barre syndrome Outcome Scores and its modification in the acute period was 5 and 10 points respectively (poor prognosis), which foreshadowed a long rehabilitation process and incomplete recovery. However, the regression of disorders was dramatic and complete, and by the second month of the disease, only minimal motor disorders remained. In the second patient, on the contrary, the total Erasmus Guillain–Barre syndrome Outcome Scores and its modification during the period of increasing symptoms was 3 and 7 points respectively (good prognosis), while recovery was delayed – only by 5 months from the onset of the disease, the ability to move with support was restored.Conclusion. The Guillain–Barre syndrome is a disease with a favorable prognosis for recovery. However, the prediction of regression of motor disorders should be approached carefully, because in some cases, generally accepted criteria and prognostic scales may not work. Acute motor axonal neuropathy with conduction blocks is a unique form of the disease that has pathophysiological and clinical-neurophysiological features, which should be taken into account when managing this category of patients.

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Guillain-Barre Syndrome and its Variants: Clinical Course and Prognostic Factors

Cited by 6 publications

References 19 publications

Three-year follow-up outcomes of adult patients with Guillain-Barré Syndrome after rehabilitation

Three-year follow-up outcomes of adult patients with Guillain-Barré Syndrome after rehabilitation

Clinical subtypes, seasonality, and short-term prognosis of Guillain-Barré syndrome in an Eastern city of Turkey

Specificity of recovery in acute motor axonal neuropathy with conduction blocks on the example of two clinical cases

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