Guillain-Barré syndrome and glioblastoma

IntroductionSystemic malignant diseases cause the induction of autoimmunity, for example, paraneoplastic syndromes. There are no proofs of paraneoplastic syndromes in primary brain tumors. The aim of the study was to evaluate the involvement of the peripheral nervous system, together with an assessment of onconeuronal and antineural antibodies as indicators of humoral immune response against nervous system in patients with primary brain tumors.Materials and MethodsClinical examinations, electrophysiological studies of peripheral nerves (motor and sensory conduction velocity studies, conduction velocity distribution tests, thermal and vibratory quantitative sensory tests, and sympathetic skin response tests) and muscles, blood sampling collection (assessment of onconeuronal, and antineural antibodies) were performed on 33 patients with newly recognized primary brain tumors within 2–4 days after their admission to our department.ResultsWe revealed statistically significant changes of peripheral nerves, more pronounced in the peroneal nerve in standard and conduction velocity distribution tests, as well as in sympathetic skin responses. We revealed significantly higher vibratory thresholds, and pain thresholds for cold and warm in the upper and lower limbs in the study group than in the controls. In five patients, we have identified anti‐neuroendothelium, anti‐GFAP, anti‐MAG, anti‐PCNA, and anti‐Ro52 antibodies.ConclusionsIn patients with primary brain tumors, electrophysiological changes in peripheral nerves, together with the presence of the antineural antibodies suggest an autoimmune humoral response, and make the diagnosis of paraneoplastic neurological syndrome possible.

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“…; Melguizo et al. ; Nakano et al. ) of possible paraneoplastic syndromes associated with primary brain tumors.…”

Section: Introductionmentioning

confidence: 99%

Is peripheral paraneoplastic neurological syndrome possible in primary brain tumors?

et al. 2016

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“…Paraneoplastic syndromes have rarely been described in primary brain tumours, 1,9 including a case report of Guillain-Barré syndrome (GBS) in a patient undergoing chemotherapy for GBM. 11 As well, in a study of 33 patients with primary brain tumours, including 15 with GBM, abnormalities were detected in both sensory and motor peripheral nerves compared with controls, but no antineuronal antibodies were found. 9 Our patient's extra-ocular movement abnormalities were consistent with patchy involvement of his cranial nerves, suggestive of an inflammatory aetiology rather than neoplastic invasion.…”

Section: Discussionmentioning

confidence: 94%

“…8 Paraneoplastic syndromes have rarely been found to be associated with primary brain malignancies, including GBM. [9][10][11] We report the first documented case of GBM presenting with bilateral asymmetric ophthalmoplegia in a paediatric patient. The tumour was supratentorial with no brainstem involvement, suggesting a paraneoplastic cause for the ophthalmoplegia.…”

Section: Introductionmentioning

confidence: 94%

Paraneoplastic Ophthalmoplegia as the Presenting Sign of Paediatric Glioblastoma Multiforme: A Case Report

Dhoot

Just

Bursztyn

2020

Neuro-Ophthalmology

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Glioblastoma multiforme (GBM) is an aggressive glioma that is infrequently diagnosed in the paediatric population. GBM and other primary brain tumours have rarely been associated with paraneoplastic syndromes. We report an unusual case of an 8-year-old boy presenting with an inability to abduct his left eye and almost complete ophthalmoplegia of his right eye, prior to any radiological evidence of GBM. This is the first documented case of paediatric GBM presenting with bilateral asymmetric ophthalmoplegia.

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“…Of all MG patients, 10–20% can be considered a PNS associated with a thymoma [ 13 ]. Only few cases of possible PNS in combination with primary brain tumors have been described [ 14 ]. To the best of our knowledge, this is the first case reporting the onset of MG during the early postoperative phase after glioblastoma (GBM) resection.…”

Section: Introductionmentioning

confidence: 99%

Myasthenia gravis after glioblastoma resection: paraneoplastic syndrome or coincidence? A unique case report and review of the literature

et al. 2021

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Paraneoplastic neurological syndromes (PNS) can manifest with every type of malignancy. A well-known syndrome is myasthenia gravis (MG) in combination with thymomas. No association between primary brain tumors and neuromuscular disorders has been described. Here, we present a case of a 65-year-old patient who developed MG, following an uncomplicated, gross-total resection of a glioblastoma. To our knowledge, this is the first case describing the onset of MG during the early postoperative phase after glioblastoma resection. Current criteria of PNS are insufficient when the neurological syndrome is diagnosed at the time of a malignancy or shortly thereafter and should be revisited.

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Guillain-Barré syndrome and glioblastoma

Cited by 3 publications

References 7 publications

Is peripheral paraneoplastic neurological syndrome possible in primary brain tumors?

Is peripheral paraneoplastic neurological syndrome possible in primary brain tumors?

Paraneoplastic Ophthalmoplegia as the Presenting Sign of Paediatric Glioblastoma Multiforme: A Case Report

Myasthenia gravis after glioblastoma resection: paraneoplastic syndrome or coincidence? A unique case report and review of the literature

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