Guillain-Barré syndrome and dengue fever: report on ten new cases in Brazil

Fragoso, Yára Dadalti; Gomes, Sidney; Brooks, Joseph Bruno Bidin; Matta, André Palma da Cunha; Ruocco, Heloisa Helena; Tauil, Carlos Bernardo; Sousa, Nise Alessandra de Carvalho; Spessotto, Caroline Vieira; Grippe, Talyta Cortez

doi:10.1590/0004-282x20160161

Cited by 19 publications

(14 citation statements)

References 8 publications

(5 reference statements)

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“…Previous evidence suggests the association between arbovirus infection and GBS [19][20][21][22][23][24][25]. Regarding the frequent and intense dengue, chikungunya, and Zika epidemics, there are few cases described involving neurological complications associated with infection by these viruses.…”

Section: Discussionmentioning

confidence: 99%

Guillain-Barré syndrome associated with arboviruses in the state of Pernambuco in 2016

2019

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Introduction: In 2016, Brazil presented an increase in the notifications related to neurological syndromes with previous register of a febrile illness compatible with arboviruses, including Guillain-Barré syndrome (GBS). Such disease is responsible for the most frequent occurrence of flaccid paralysis in the world, causing bilateral ascending muscle weakness that might affect the respiratory tract. Objective: To investigate the incidence of Guillain-Barré syndrome associated with arboviruses in Pernambuco in 2016 and to describe the confirmed/probable cases. Method: This is an observational retrospective study of GBS cases with a background of infection from dengue, chikungunya, or Zika virus notified to the Pernambuco Health State Secretariat (SES-PE). Cases notified from January 1st to December 31st, 2016 were included, which were considered as possible GBS at the time of notification. The suspect cases were investigated and classified as confirmed/probable by the positive laboratory test result, excluding the possibility of infection. Results: Forty-three suspect cases of GBS after previous arbovirus infection were notified. From these, 23 were classified as confirmed/probable for the etiological agents chikungunya and/or dengue. The mean age of the affected individuals was 37.22 ± 21.29 years and they were mostly female (56.5%). The annual incidence of GBS after arbovirus infection was 0.24 cases per 100 thousand inhabitants in the state. The neurological condition was mainly characterized by the presence of movement (91.3%) and walking (78.3%) alterations. Conclusion: The findings of this research confirm the current set of evidence and show the likelihood of GBS being a severe neurological complication of these arboviruses.

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Section: Discussionmentioning

confidence: 99%

Guillain-Barré syndrome associated with arboviruses in the state of Pernambuco in 2016

2019

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“…described ten cases of GBS with dengue fever. Neurological manifestations in this case series were often severe, but recovery was mostly as complete and fast as in our case described here [ 9 ]. Soares et al .…”

Section: Discussionmentioning

confidence: 55%

Dengue fever complicated with Guillain-Barré syndrome: a case report and review of the literature

Dalugama

Shelton²,

Ekanayake³

et al. 2018

J Med Case Reports

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BackgroundDengue is an arboviral infection classically presenting with fever, arthralgia, headache, and rashes. It is hyperendemic in Sri Lanka and has a major impact on health. Neurological complications of dengue fever are rare but have been reported in the literature.Case presentationA 60-year-old Sri Lankan man presented with a history of fever, arthralgia, and generalized malaise of 2 days duration. A diagnosis of dengue was confirmed with leukopenia, thrombocytopenia, and positive NS1 antigen done on day 2 without evidence of hemoconcentration. On admission, our patient had weakness of the bilateral lower limbs, which progressed in an ascending pattern involving both upper limbs and neck muscles, requiring assisted ventilation. Electromyography confirmed a demyelinating polyneuropathy and cerebrospinal fluid showed albumincytological dissociation. He was treated with intravenous immunoglobulins and made an uneventful recovery. Subsequently, his immunoglobulin M test result for dengue virus was positive.ConclusionsGuillain-Barré syndrome is a rare but possible neurological sequel following dengue fever. In regions where dengue is hyperendemic, screening for dengue illness may be important in patients presenting with acute flaccid paralysis.

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“…GBS and its variants represent 5% of neurological complications in pediatric patients who had DF 13 , the period between the onsets of the illnesses of approximately 10,9 days 26 . Acute motor and sensitive axonal neuropathy (AMSAN) was the most common GBS subtype in these patients, followed by acute motor axonal neuropathy (AMAN), acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and Miller Fisher syndrome (MFS) 12 .…”

Section: Guillain-barre Syndromementioning

confidence: 99%

<strong>Dengue Fever and Neurology: Well Beyond Hemorrhage and Strokes</strong>

Schlindwein¹,

Bandeira²,

Breis³

et al. 2020

Preprint

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Dengue virus an arbovirus is endemic in an area that comprise almost half of the world's population, contrary to past beliefs that dengue virus differentiate from other neuroinvasive arbovirus due to its lack of neurological invasion and disease related neurological complications excluding hemorrhagic and thromboembolic , the body of evidence have grown to demonstrate a series of neurological manifestations linked to dengue virus with possible mechanisms involving direct virus invasion of the nervous system or immune mediated complications. In this review we provide a wide approach to this neglect but not so rare manifestations of a very common disease.

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Guillain-Barré syndrome and dengue fever: report on ten new cases in Brazil

Cited by 19 publications

References 8 publications

Guillain-Barré syndrome associated with arboviruses in the state of Pernambuco in 2016

Guillain-Barré syndrome associated with arboviruses in the state of Pernambuco in 2016

Dengue fever complicated with Guillain-Barré syndrome: a case report and review of the literature

<strong>Dengue Fever and Neurology: Well Beyond Hemorrhage and Strokes</strong>

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