Guillain-Barré syndrome: An update

Vucic, Steve; Kiernan, Matthew C.; Cornblath, David R.

doi:10.1016/j.jocn.2008.08.033

Cited by 224 publications

(247 citation statements)

References 155 publications

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“…Similarly, surface transplantation of appropriate motor neuron precursors may ameliorate neurological deficit due to poliomyelitis in which anterior horn cells degenerate (52). Patients with neurological sequelae from peripheral neuropathy with spinal cord or brainstem involvements may also be candidates for surface transplantation (53). We demonstrated that elongated, astrocytic processes after trauma played a crucial role in cell migration (Fig.…”

Section: Discussionmentioning

confidence: 71%

Cells transplanted onto the surface of the glial scar reveal hidden potential for functional neural regeneration

Sekiya

Holley

Hashido

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Cell transplantation therapy has long been investigated as a therapeutic intervention for neurodegenerative disorders, including spinal cord injury, Parkinson’s disease, and amyotrophic lateral sclerosis. Indeed, patients have high hopes for a cell-based therapy. However, there are numerous practical challenges for clinical translation. One major problem is that only very low numbers of donor cells survive and achieve functional integration into the host. Glial scar tissue in chronic neurodegenerative disorders strongly inhibits regeneration, and this inhibition must be overcome to accomplish successful cell transplantation. Intraneural cell transplantation is considered to be the best way to deliver cells to the host. We questioned this view with experiments in vivo on a rat glial scar model of the auditory system. Our results show that intraneural transplantation to the auditory nerve, preceded by chondroitinase ABC (ChABC)-treatment, is ineffective. There is no functional recovery, and almost all transplanted cells die within a few weeks. However, when donor cells are placed on the surface of a ChABC-treated gliotic auditory nerve, they autonomously migrate into it and recapitulate glia- and neuron-guided cell migration modes to repair the auditory pathway and recover auditory function. Surface transplantation may thus pave the way for improved functional integration of donor cells into host tissue, providing a less invasive approach to rescue clinically important neural tracts.

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Section: Discussionmentioning

confidence: 71%

Cells transplanted onto the surface of the glial scar reveal hidden potential for functional neural regeneration

Sekiya

Holley

Hashido

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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“…are the causative agents of campylobacteriosis (Rosenquist et al 2003, Butzler 2004, a zoonotic disease (WHO 2000) transmitted to human beings mainly by the consumption of contaminated poultry products (Dickins et al 2002). In the European Union (EFSA 2012) and in the United States (CDC 2013) Campylobacter jejuni and Campylobacter coli are often associated with gastroenteritis, and C. jejuni is also implicated in Guillain-Barré syndrome (Vucic et al 2009 Campylobacter jejuni and C. coli have been associated with gastrointestinal disorders in human beings, due mainly to the consumption of chicken meat. Despite control measures for reducing contamination by these bacteria, the detection of Campylobacter in carcasses after chilling remains high.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of Campylobacter jejuni and C. coli on broiler carcasses after chilling in southern Brazil

et al. 2015

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Campylobacter jejuniand C. colihave been associated with gastrointestinal disorders in human beings, due mainly to the consumption of chicken meat. Despite control measures for reducing contamination by these bacteria, the detection of Campylobacter in carcasses after chilling remains high.A total of 105 carcasses were assessed by the horizontal detection method in five federally inspected slaughterhouses in southern Brazil in 2012 and in the first three months of 2013. Campylobacterwas isolated in 37.1% of the carcasses, of which 97.5% contained C. jejuni and 2.5% were infected by C. coli. The rate of positive carcasses across the slaughterhouses ranged from 0 to 71.4%. Determining the occurrence of Campylobacteramong flocks is crucial for estimating the microbial load at specific points along the slaughtering process and for minimizing the risk of contamination of end products by Campylobacter.

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“…To our knowledge, a seasonal preponderance in incidence has not been reported with significant difference. 1,[4][5][6]16,[19][20][21] Some of these studies show more cases in colder months. 16,21 One of the largest epidemiological studies conducted in southwest Netherlands 4 shows more cases during the winter and June, in Brazil a cluster of cases in spring and summer was reported 22 and in Sweden autumn was the season with most GBS cases.…”

Section: Discussionmentioning

confidence: 97%

Epidemiology of Guillain–Barré Syndrome in Aruba

Suryapranata

Ang

Chong

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. The epidemiology of Guillain-Barré syndrome (GBS) in tropical areas is different compared with developed countries. We investigated the epidemiology of GBS on the Caribbean island of Aruba. Data were collected retrospectively from all 36 patients hospitalized with GBS between 2003 and 2011 in Aruba. We observed a seasonal distribution of GBS cases with a peak in February. The incidence rate (IR) fluctuated heavily between individual years. The overall IR was 3.93/100,000, which is higher than that observed in developed countries. Serological studies indicated a possible relation of GBS cases with dengue virus infections. We also observed a relation between the annual number of dengue cases in Aruba and the number of GBS cases in the same year. We conclude that the epidemiology of GBS in tropical areas can be different from temperate climate regions and that dengue may be a trigger for developing GBS.

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Guillain-Barré syndrome: An update

Cited by 224 publications

References 155 publications

Cells transplanted onto the surface of the glial scar reveal hidden potential for functional neural regeneration

Cells transplanted onto the surface of the glial scar reveal hidden potential for functional neural regeneration

Occurrence of Campylobacter jejuni and C. coli on broiler carcasses after chilling in southern Brazil

Epidemiology of Guillain–Barré Syndrome in Aruba

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