Guignardones P–S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra

Sun, Zhang‐Hua; Liang, Fa-Liang; Wu, Wen; Chen, Yuchan; Pan, Qingling; Li, Haohua; Wei, Ye; Liu, Hongxin; Li, Saini; Tan, Genjia; Zhang, Weimin

doi:10.3390/molecules201219890

Cited by 29 publications

(18 citation statements)

References 18 publications

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“…However, one of these products, guignardic acid, has also been reported from P. capitalensis [80]. Biosynthetic abilities by endophytic strains of the latter species also refer to meroterpenes, such as compounds in the guignardone series [81][82][83][84] and the manginoids [85]. Besides a likely implication in the relationships with other citrus-associated microbial species, the bioactive properties of the dioxolanones and the related meroterpene compounds deserve to be further investigated in view of possible pharmaceutical exploitation [79,86].…”

Section: Biotechnological Implicationsmentioning

confidence: 99%

Endophytic Fungi of Citrus Plants

Nicoletti

2019

Agriculture

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Besides a diffuse research activity on drug discovery and biodiversity carried out in natural contexts, more recently, investigations concerning endophytic fungi have started considering their occurrence in crops based on the major role that these microorganisms have been recognized to play in plant protection and growth promotion. Fruit growing is particularly involved in this new wave, by reason that the pluriannual crop cycle likely implies a higher impact of these symbiotic interactions. Aspects concerning occurrence and effects of endophytic fungi associated with citrus species are revised in the present paper.Agriculture 2019, 9, 247 2 of 13 similar but fast-growing, and producing conidia embedded within a thicker mucoid sheath [4][5][6][7][8]. The latter, characterized as a different species (Phyllosticta capitalensis), are known to be ubiquitous as endophytes in woody plants, having been reported from at least 70 botanical families [6,9,10]. Guignardia endophyllicola, treated as a separate species in a work also emphasizing its widespread endophytic occurrence [11], is at present recognized as a synonym. Differences between the two sister species also concern their metagenetic cycle. In fact, it has been ascertained that P. citricarpa is heterothallic, while P. capitalensis is homothallic [8]. This consolidated taxonomic distinction supports the exclusion from quarantine measures of plant material harbouring P. capitalensis. To this purpose, several rapid PCR assays have been developed [12][13][14][15][16][17][18][19][20]. The applicative use of these assays has enabled to exclude the presence of the pathogen in New Zealand, unlike what was previously assumed [21], and has supported the hypothesis of the possible endophytic occurrence of P. citricarpa in asymptomatic Citrus spp., as pointed out by several investigations (Table 1). Moreover, the two species have been clearly differentiated on account of their enzymatic profiles, with a higher expression of amylases, endoglucanases, and pectinases in P. citricarpa, suggesting a likely involvement of these enzymes in the pathogenic aptitude of the CBS agent [22]. Differences in terms of pathogenesis-related proteins have been confirmed after the genome sequencing of the two species, disclosing a higher number of coding sequences in P. citricarpa (15,206 versus 14,797). Such a difference has been interpreted considering the presence of growth and developmental genes involved in the expression of pathogenicity [23].The issue of detection of contaminated material imported from areas where the pathogen is endemic has also prompted investigations concerning the assortment of Phyllosticta spp. able to colonize citrus plants in either symptomatic or latent courses. Several revisions have been published [17,24], and novel species characterized, which consistently enlarge the citrus-associated consortium within this widespread genus. Particularly, the pathogenic P. citriasiana from south-east Asia [25], P. citrichinaensis from China [26], P. citrimaxima from Thailand...

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Section: Biotechnological Implicationsmentioning

confidence: 99%

Endophytic Fungi of Citrus Plants

Nicoletti

2019

Agriculture

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“… 18 , 21 – 26 , Pycnoporus sanguineus 27 , and Aspergillus sp. 28 , and they showed antifungal 18 , antibacterial 23 , cytotoxic 25 , and Toll-Like Receptor 3 regulating activities 26 . Guignardianones are a special kind of fungal-derived benzylidene dioxolanone derived from the amino acid pathway 15 , 29 , 30 , and they exhibit antifungal 18 and antibacterial 31 activities.…”

Section: Discussionmentioning

confidence: 99%

Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities

Yang

Zhao

et al. 2017

Sci Rep

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Phyllomeroterpenoids A−C (1−3), multi-biosynthetic pathway derived meroterpenoids from amino acid/pentose phosphate/terpenoid pathways, were isolated from the TCM endophytic fungus Phyllosticta sp. J13-2-12Y, together with six biosynthetically related compounds (4−9). All structures were determined by extensive spectroscopic analysis, chemical derivatization, and ECD experiments. A plausible biosynthetic pathway of 1−3 was proposed. In addition, the antimicrobial activities of all isolated compounds were evaluated against Staphylococcus aureus 209P (bacterium) and Candida albicans FIM709 (fungus).

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“…However one of these products, guignardic acid, has been also reported from P. capitalensis [80]. Biosynthetic abilities by endophytic strains of the latter species also refer to meroterpenes, such as compounds in the guignardone series [81][82][83][84] and the manginoids [85].…”

Section: Biotechnological Implicationsmentioning

confidence: 99%

Endophytic Fungi of Citrus Plants

Nicoletti¹

2019

Preprint

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Besides a diffuse research activity on drug discovery and biodiversity carried out in natural contexts, more recently investigations concerning endophytic fungi have started considering their occurrence in crops based on the major role that these microorganisms have been recognized to play in plant protection and growth promotion. Fruit growing is particularly involved in this new wave, by reason that the pluriannual crop cycle implies a likely higher impact of these symbiotic interactions. Aspects concerning occurrence and effects of endophytic fungi associated with citrus species are revised in the present paper.

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Guignardones P–S, New Meroterpenoids from the Endophytic Fungus Guignardia mangiferae A348 Derived from the Medicinal Plant Smilax glabra

Cited by 29 publications

References 18 publications

Endophytic Fungi of Citrus Plants

Endophytic Fungi of Citrus Plants

Phyllomeroterpenoids A-C, Multi-biosynthetic Pathway Derived Meroterpenoids from the TCM Endophytic Fungus Phyllosticta sp. and their Antimicrobial Activities

Endophytic Fungi of Citrus Plants

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