An approach is offered here to assist the pathologist with the actual dissection of the operated heart at autopsy. The challenge to the pathologist is to define any underlying cardiac pathology, recognize changes in morphology brought about by prior surgical intervention, and correlate the gross cardiac findings with the hemodynamic status of the deceased prior to death. Even without detailed clinical records, one can still perform the dissection in a consistent and careful manner that allows an accurate assessment of the heart regardless of postoperative adhesions and complex surgical reconstructions. Developing the plane of dissection between the heart and adherent parietal pericardium should be done with a scalpel, using a methodical technique. As one examines the external surface of the heart, one may observe clues that the surgeon had used cardiopulmonary bypass to rest the heart during surgery and that specific surgical procedures had been performed. By removal of the coronary arteries with any bypass grafts off the heart and subsequent careful examination of the chambers and great vessels of the heart, the pathologist can then begin to understand the "real story." Keywords Dissection · Pericardium · Heart surgery · Coronary arteries · Surgical footprints · Cardiopulmonary bypass · Sharp dissection In this chapter, an approach is offered to assist the pathologist with the actual dissection of the operated heart at autopsy. This dissection, depending on what operation was done and how long prior to autopsy the operation was performed, may range in complexity from a simple procedure to quite a daunting task. The challenge to the pathologist is to define any underlying cardiac pathology, recognize changes in morphology brought about by prior surgical intervention, and correlate the gross cardiac findings with the hemodynamic status of the deceased prior to death. In short, to what extent did failure of cardiac function contribute to the person's death, and how did the previous heart surgery affect the outcome of the case?Having a detailed knowledge of the deceased's past surgical history, as provided by operative notes, hospital discharge summaries, and available informed clinicians is an obvious advantage to the pathologist at autopsy. However, even without this 31 S.L. Houser, The Operated Heart at Autopsy,