Guiding Ketogenic Diet with Breath Acetone Sensors

Güntner, Andreas T.; Kompalla, Julia F.; Landis, Henning; Theodore, S.J.; Geidl, Bettina; Sievi, Noriane A.; Kohler, Malcolm; Pratsinis, Sotiris E.; Gerber, Philipp A.

doi:10.3390/s18113655

Cited by 67 publications

(56 citation statements)

References 55 publications

(98 reference statements)

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“…In some cases of breath analysis or indoor air quality monitoring, even the NH 3 selectivity of CuBr may be insufficient. In fact, the selectivity to hydrogen and acetone is ≈60, but both can reach exhaled breath concentrations of tens of ppm (e.g., acetone during ketogenic diet32 or H 2 in case of carbohydrate intolerance33). Also ethanol (selectivity ≈40) may be present at high ppm concentrations in the background of hospital air from disinfectants or cleaning agents 34.…”

Section: Resultsmentioning

confidence: 99%

Rapid and Selective NH₃ Sensing by Porous CuBr

et al. 2020

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Fast and selective detection of NH3 at parts‐per‐billion (ppb) concentrations with inexpensive and low‐power sensors represents a long‐standing challenge. Here, a room temperature, solid‐state sensor is presented consisting of nanostructured porous (78%) CuBr films. These are prepared by flame‐aerosol deposition of CuO onto sensor substrates followed by dry reduction and bromination. Each step is monitored in situ through the film resistance affording excellent process control. Such porous CuBr films feature an order of magnitude higher NH3 sensitivity and five times faster response times than conventional denser CuBr films. That way, rapid (within 2.2 min) sensing of even the lowest (e.g., 5 ppb) NH3 concentrations at 90% relative humidity is attained with outstanding selectivity (30–260) over typical confounders including ethanol, acetone, H2, CH4, isoprene, acetic acid, formaldehyde, methanol, and CO, superior to state‐of‐the‐art sensors. This sensor is ideal for hand‐held and battery‐driven devices or integration into wearable electronics as it does not require heating. From a broader perspective, the process opens exciting new avenues to also explore other bromides and classes of semiconductors (e.g., sulfides, nitrides, carbides) currently not accessible by flame‐aerosol technology.

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Section: Resultsmentioning

confidence: 99%

Rapid and Selective NH₃ Sensing by Porous CuBr

et al. 2020

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“…Acidosis was reported as a decreased alkali (excessive acid) in the body fluids (Dehkordi & Dehkordi, 2011). Clinical signs of ketosis were anorexia, depression, and odor of acetone in the breath (Güntner et al, 2018).…”

Section: Reproduction and Metabolic Disordersmentioning

confidence: 99%

Reproductive Responses, Metabolic Disorder, Ruminal Fermentation Characteristics, and Milk Production of Postpartum Holstein Cows Fed Steam Flaked of Corn and Barley Grains

Ahmadijoo

Yarahmadi

Fakhraei

et al. 2020

Trop. Anim. Sci. J.

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This study evaluated the effects of steam flaked of corn and barley grains on the reproductive response, ruminal fermentation characteristics, metabolic disorder, and milk production of postpartum Holstein cows. A total of 40 postpartum Holstein dairy cows were divided into 4 groups (n=10) and fed 1) ground grains (control), 2) steam flacked corn+milled barley, 3) steam flacked barely+milled corn, and 4) steam flaked corn and barley. The animals were treated for 0-30, 30-60, 60-90, and 90-120 days post-calving. Milk yield and compositions, total conception rate, endometritis, pyometra, ruminal fermentation characteristics, ketosis, and acidosis were assessed. This study was conducted in a completely randomized design. The results showed that dietary inclusion of steam flaked grains improved milk yield and compositions during the experimental period compared to the control group (p<0.05), except for cows treated for 0-30d days post-calving. Cows fed steam flaked grains showed a lower occurrence of reproduction and metabolic disorders compared to the control group (p<0.01). Cows fed a combination of steam flaked grains showed better pregnancy rates in the first 100 days and open days of postpartum cows compared to cows in control and a single form of steam flaked barley or corn (p<0.05). Total VFA, acetate, propionate, butyrate, and valerate were higher in cows fed steam flaked compared to the control group (p<0.05). Feeding steam flaked grains is advised for improving reproductive performance, milk variables, and rumen fermentation profiles in dairy cows.

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“…The secondary effects are beneficial for overweight patients but not for cachectic cancer patients therefore and due to the ketone-body formation one should use LCD carefully, just with a moderate decrease of carbohydrate intake. For those frail patients who need an aggressive ketogenic diet, in our days we have an easy and noninvasive method (acetone breath test) with which therapy can be controlled thoroughly [9].…”

Section: Low Carbohydrate Diet (Lcd)mentioning

confidence: 99%

The position of low carb diet in the cancer adjuvant therapy: Clinical nutrition with low carb diet in cancer patients

2019

Asp Biomed Clin Case Rep

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Low carbohydrate diet (Low Carb Diet; LCD) is known for ages and exert a positive effect on the health-related quality of life in plenty of people [1]. It is also used over 100 years as a therapeutic tool in various illnesses. In epilepsy this – and the more aggressive version, the ketogenic diet (KD) – is a well-accepted evidence-based treatment modality for patients suffering from pharmacotherapy resistant type of the illness [2]. LCD is also used as a slimming diet among others under the name “Atkins diet“, that has been introduced for public ca. 50 years ago (Atkins Nutritional Approach). However, originally it was developed by cardiologist Robert C. Atkins to publish his concept of healthy eating to help patients with obesity and related health problems (mainly cardiovascular disease, today, in a broader sense, the cardiometabolic syndrome). Public advantages of its moderate version has also been recently demonstrated by NIPPON DATA [3]. Oncological use of carbohydrate-restricted diet started earlier but research activity of Nobel laureate (1924) Otto Warburg supplied the real scientific background to continue this type of therapy in cancer patients. According to his hypothesis tumor cells mainly get energy from anaerobic glycolysis that is not normal in healthy human cells [4]. Of course, we know already that tumor cell metabolism is much more complex.

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Guiding Ketogenic Diet with Breath Acetone Sensors

Cited by 67 publications

References 55 publications

Rapid and Selective NH₃ Sensing by Porous CuBr

Rapid and Selective NH₃ Sensing by Porous CuBr

Reproductive Responses, Metabolic Disorder, Ruminal Fermentation Characteristics, and Milk Production of Postpartum Holstein Cows Fed Steam Flaked of Corn and Barley Grains

The position of low carb diet in the cancer adjuvant therapy: Clinical nutrition with low carb diet in cancer patients

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Guiding Ketogenic Diet with Breath Acetone Sensors

Cited by 67 publications

References 55 publications

Rapid and Selective NH3 Sensing by Porous CuBr

Rapid and Selective NH3 Sensing by Porous CuBr

Reproductive Responses, Metabolic Disorder, Ruminal Fermentation Characteristics, and Milk Production of Postpartum Holstein Cows Fed Steam Flaked of Corn and Barley Grains

The position of low carb diet in the cancer adjuvant therapy: Clinical nutrition with low carb diet in cancer patients

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Rapid and Selective NH₃ Sensing by Porous CuBr

Rapid and Selective NH₃ Sensing by Porous CuBr