Guiding Epilepsy Surgery with an LRP1-Targeted SPECT/SERRS Dual-Mode Imaging Probe

Li, Zhi; Sun, Wen; Duan, Wenjia; Jiang, Yiqing; Chen, Ming; Lin, Guorong; Wang, Qinyue; Fan, Zhen; Tong, Yusheng; Luo, Chen; Li, Jianing; Cheng, Guangli; Li, Cong; Chen, Liang

doi:10.1021/acsami.2c02540

Cited by 10 publications

(9 citation statements)

References 33 publications

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“…SPECT, which is characterized by the specific display of the blood flow, function and metabolic changes in organs or lesions, facilitates early and specific diagnosis of various diseases including malignant tumors, Alzheimer's disease and epilepsy. 37–39 Meanwhile, SPECT imaging can be utilized to directly observe the distribution of 99m Tc-labeled nanomaterials and investigate the radioactivity of specific organs and tumors. In order to analyze the SPECT imaging potential of the CSTDs, G3/G3-DOTA-Cy5.5-PS and P-G2.5/G3-DOTA-Cy5.5-PS CSTDs were labeled with 99m Tc with a labeling efficiency of 83.33 ± 2.98% and 62.34 ± 4.16%, respectively, and they displayed excellent radio stability as demonstrated by evaluation of their radiochemical purities at different time points (Table S2†).…”

Section: Resultsmentioning

confidence: 99%

“…SPECT, which is characterized by the specific display of the blood flow, function and metabolic changes in organs or lesions, facilitates early and specific diagnosis of various diseases including malignant tumors, Alzheimer's disease and epilepsy. [37][38][39] Meanwhile, SPECT imaging can be utilized to directly observe the distribution of 99m Tc-labeled nanomaterials and investigate the radioactivity of specific organs and tumors. In order to analyze the SPECT imaging potential Quantification of the SPECT signal at the tumor site shows a trend of first increase and then decrease over time postinjection, and a peak SPECT signal at 60 min postinjection can be seen for both groups (Fig.…”

Section: Spect Imaging Of Tumors In Vivomentioning

confidence: 99%

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Phosphorus core–shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters

Zhan,

Wang,

Zhao

et al. 2023

Biomater. Sci.

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Section: Resultsmentioning

confidence: 99%

“…SPECT, which is characterized by the specific display of the blood flow, function and metabolic changes in organs or lesions, facilitates early and specific diagnosis of various diseases including malignant tumors, Alzheimer's disease and epilepsy. [37][38][39] Meanwhile, SPECT imaging can be utilized to directly observe the distribution of 99m Tc-labeled nanomaterials and investigate the radioactivity of specific organs and tumors. In order to analyze the SPECT imaging potential Quantification of the SPECT signal at the tumor site shows a trend of first increase and then decrease over time postinjection, and a peak SPECT signal at 60 min postinjection can be seen for both groups (Fig.…”

Section: Spect Imaging Of Tumors In Vivomentioning

confidence: 99%

Phosphorus core–shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters

Zhan,

Wang,

Zhao

et al. 2023

Biomater. Sci.

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Section: Bioinorganic Materials For Imaging Of Epilepsymentioning

confidence: 99%

“…[ 40 ] Li and co‐workers delineated the epilepsy edge in a high‐contrast manner via surface‐enhanced resonance Raman scattering (SERRS). [ 41 ] As shown in Figure 1d, the probe (named 99m Tc‐ACS@AuS) with high SERRS sensitivity and stability is composed of six components: amine‐terminated G1 polyamidoamine (PAMAM) dendrimers as functionalized core carriers, gold nanostars (AuS) as enhancement base, flowering cyanine dyes as Raman reporter molecules, 99mTcdiethylenetriaminepentaacetic acid (DTPA) as a radiographic moiety, PEG as a protective shell, and angiopep 2 as targeting ligands for LRP1 binding. After tail vein injection of 99m Tc‐ACS@AuS, signals were detected by a handheld Raman scanner, which resulted in the successful outlining of the EF by detecting the characteristic Raman peaks (520 and 553 cm −1 ) of 99m Tc‐ACS@AuS.…”

Section: Bioinorganic Materials For Imaging Of Epilepsymentioning

confidence: 99%

Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease

Zhao,

Ngai,

Wang

et al. 2024

Small Structures

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The treatment of neurological disease, such as epilepsy is rather complicated. Emerging therapies such as surgery, gene therapy, stem cell transplantation, and neurostimulation have been developed to replace traditional drug therapy. However, great challenges such as the difficult localization of epileptic foci (EF), incomplete excision of lesioned nerves, high drug resistance, and severe side effects limit their clinical applications. As an alternative, bioinorganic materials have been emerged and show great potentials for epilepsy theranostics. Their unique physical properties, including fluorescence, magnetic resonance effect, and surface‐enhanced Raman scattering effect (SERS), give them the ability to image the localization of EF. In addition, the fluorescence and conductivity of bioinorganic materials could be further used for studying pathogenesis. Moreover, bioinorganic materials could serve as intelligent systems to deliver drugs and cooperative therapy for epilepsy. Herein, this review highlights the design and application of bioinorganic materials in the imaging, diagnosis, and therapy of epilepsy. Furthermore, light is shown on the potential bottlenecks and future perspectives of bioinorganic materials in epilepsy theranostics.

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“…Recently, Wang and co‐workers developed an LRP1‐targeted SPECT/Raman dual‐mode imaging probe for epilepsy surgery that could co‐registries SPECT preoperatively and surface‐enhanced resonance Raman scattering images intraoperatively. [ 126 ] All the results show that LRP1 is a potential biomarker for epilepsy, and it is of great value in the localization of the EF.…”

Section: Imaging Epileptic Foci By Locating Molecular Abnormalitiesmentioning

confidence: 99%

Tailoring Materials for Epilepsy Imaging: From Biomarkers to Imaging Probes

Zhao

Sun

2022

Advanced Materials

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Epilepsy is a recurrent, episodic, and complex neurological syndrome characterized by an enduring predisposition to epileptic seizures and consequent neurological, cognitive, psychological, and social problems. [1] An epileptic seizure is a transient occurrence of symptoms (such as temporary confusion, staring spells, uncontrollable jerking, and loss of awareness) caused by abnormal neuronal electrical activities. [2] As a serious health problem, epilepsy affects ≈1% of the global population, [3] and nearly 5 million people worldwide are diagnosed with epilepsy every year. Although there are now more than 20 antiseizure medications (ASMs) in active clinical use, [4] ≈20-30% of epilepsy patients fail to achieve sustained seizure freedom after adequate trial of two appropriately chosen ASMs. [5] These drugresistant epilepsy (DRE) patients are at an increased risk of injury and death, [6] unbearable medication burden and adverse effects, increased psychiatric and neurocognitive comorbidities, [7] and socioeconomic disadvantage. Therefore, the management of DRE in the clinic is a major challenge.Resection of the epileptic foci (EF), defined as the minimum area of the brain tissue that must be resected or disconnected for the abolishment of seizures, [8] is the most efficient approach for the treatment of DRE patients. [9] First, epilepsy surgery increases the prospects of patients being seizure-free. [10] Approximately 52% of the patients have no disabling seizures for 5 years after surgery, and nearly half of the patients remain free from seizures for 10 years. [11] Second, surgical treatment reduces DRE patients' mortality by two to three times [12] and extends life expectancy by an average of 5 years in comparison to patients who have received drug therapy. [13] Third, epilepsy surgery reduces individual medical expenditures for families. [14] Overall, these results suggest that DRE is potentially curable with surgical intervention. Accurate identification of the EF is a prerequisite for achieving satisfactory postsurgical outcomes. [15] However, only a small percentage of patients is recommended for surgical treatment because of the difficulty in defining EF. First, an initial clinical assessment, including history of epilepsy, semiology information, drug history, and comorbidity, will be performed in the clinic to confirm whether the patients are suitable for surgery. Next, high-resolution structural magnetic resonance imaging (MRI) and long-term inpatient video electroencephalography (EEG) are conducted. [16] If MRI shows Excising epileptic foci (EF) is the most efficient approach for treating drugresistant epilepsy (DRE). However, owing to the vast heterogeneity of epilepsies, EF in one-third of patients cannot be accurately located, even after exhausting all current diagnostic strategies. Therefore, identifying biomarkers that truly represent the status of epilepsy and fabricating probes with high targeting specificity are prerequisites for identifying the "concealed" EF. However, no systematic summary of thi...

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Guiding Epilepsy Surgery with an LRP1-Targeted SPECT/SERRS Dual-Mode Imaging Probe

Cited by 10 publications

References 33 publications

Phosphorus core–shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters

Phosphorus core–shell tecto dendrimers for enhanced tumor imaging: the rigidity of the backbone matters

Bioinorganic Materials for Imaging, Diagnosis and Therapy of Neurological Disease

Tailoring Materials for Epilepsy Imaging: From Biomarkers to Imaging Probes

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