Guiding and Accumulation of Magnetic Nanoparticles Employing High Intensity Focused Ultrasound for Drug Targeting Applications

George, Benedikt; Fink, Michael; Ermert, H.; Rupitsch, Stefan J.; Lyer, Stefan; Alexiou, Christoph

doi:10.1515/cdbme-2019-0148

Cited by 3 publications

(1 citation statement)

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“…Acoustic radiation force is produced by a nonlinear effect of ultrasound and can be observed through the axial translation of suspended particles in the direction of sound propagation. This force has been shown to improve nanoparticle penetration through the tumor interstitium, especially when focused ultrasound is used (Afadzi et al, 2021; Baghirov et al, 2018; George et al, 2019; Mo et al, 2012). Other ultrasound methodologies (e.g., mechanical and thermal effects from focused ultrasound) have also been used to modulate tumor IFP to improve drug delivery (Keller & Averkiou, 2022).…”

Section: Future Predictions With Ultrasound: a Robust Strategy For Tu...mentioning

confidence: 99%

Using imaging modalities to predict nanoparticle distribution and treatment efficacy in solid tumors: The growing role of ultrasound

Cooley,

Wegierak,

Exner

2024

WIREs Nanomed Nanobiotechnol

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Nanomedicine in oncology has not had the success in clinical impact that was anticipated in the early stages of the field's development. Ideally, nanomedicines selectively accumulate in tumor tissue and reduce systemic side effects compared to traditional chemotherapeutics. However, this has been more successful in preclinical animal models than in humans. The causes of this failure to translate may be related to the intra‐ and inter‐patient heterogeneity of the tumor microenvironment. Predicting whether a patient will respond positively to treatment prior to its initiation, through evaluation of characteristics like nanoparticle extravasation and retention potential in the tumor, may be a way to improve nanomedicine success rate. While there are many potential strategies to accomplish this, prediction and patient stratification via noninvasive medical imaging may be the most efficient and specific strategy. There have been some preclinical and clinical advances in this area using MRI, CT, PET, and other modalities. An alternative approach that has not been studied as extensively is biomedical ultrasound, including techniques such as multiparametric contrast‐enhanced ultrasound (mpCEUS), doppler, elastography, and super‐resolution processing. Ultrasound is safe, inexpensive, noninvasive, and capable of imaging the entire tumor with high temporal and spatial resolution. In this work, we summarize the in vivo imaging tools that have been used to predict nanoparticle distribution and treatment efficacy in oncology. We emphasize ultrasound imaging and the recent developments in the field concerning CEUS. The successful implementation of an imaging strategy for prediction of nanoparticle accumulation in tumors could lead to increased clinical translation of nanomedicines, and subsequently, improved patient outcomes.This article is categorized under: Diagnostic Tools In Vivo Nanodiagnostics and Imaging Therapeutic Approaches and Drug Discovery Nanomedicine for Oncologic Disease Therapeutic Approaches and Drug Discovery Emerging Technologies

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Section: Future Predictions With Ultrasound: a Robust Strategy For Tu...mentioning

confidence: 99%

Using imaging modalities to predict nanoparticle distribution and treatment efficacy in solid tumors: The growing role of ultrasound

Cooley,

Wegierak,

Exner

2024

WIREs Nanomed Nanobiotechnol

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FEM based simulation of magnetic drug targeting in a multibranched vessel model

Lindemann

Luttke

Nottrodt

et al. 2021

Computer Methods and Programs in Biomedicine

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Magnetic field controlled behavior of magnetic gels studied using particle-based simulations

Weeber

Kreissl

Holm

2021

Physical Sciences Reviews

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This contribution provides an overview of the study of soft magnetic materials using particle-based simulation models. We focus in particular on systems where thermal fluctuations are important. As a basis for further discussion, we first describe two-dimensional models which demonstrate two deformation mechanisms of magnetic gels in a homogeneous field. One is based on the change of magnetic interactions between magnetic particles as a response to an external field; the other is the result of magnetically blocked particles acting as cross-linkers. Based on the qualitative behavior directly observable in the two-dimensional models, we extend our description to three-dimensions. We begin with particle-cross-linked gels, as for those, our three-dimensional model also includes explicitly resolved polymer chains. Here, the polymer chains are represented by entropic springs, and the deformation of the gel is the result of the interaction between magnetic particles. We use this model to examine the influence of the magnetic spatial configuration of magnetic particles (uniaxial or isotropic) on the gel’s magnetomechanical behavior. A further part of the article will be dedicated to scale-bridging approaches such as systematic coarse-graining and models located at the boundary between particle-based and continuum modeling. We will conclude our article with a discussion of recent results for modeling time-dependent phenomena in magnetic-polymer composites. The discussion will be focused on a simulation model suitable for obtaining AC-susceptibility spectra for dilute ferrofluids including hydrodynamic interactions. This model will be the basis for studying the signature of particle–polymer coupling in magnetic hybrid materials. In the long run, we aim to compare material properties probed locally via the AC-susceptibility spectra to elastic moduli obtained for the system at a global level.

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Guiding and Accumulation of Magnetic Nanoparticles Employing High Intensity Focused Ultrasound for Drug Targeting Applications

Cited by 3 publications

References 0 publications

Using imaging modalities to predict nanoparticle distribution and treatment efficacy in solid tumors: The growing role of ultrasound

Using imaging modalities to predict nanoparticle distribution and treatment efficacy in solid tumors: The growing role of ultrasound

FEM based simulation of magnetic drug targeting in a multibranched vessel model

Magnetic field controlled behavior of magnetic gels studied using particle-based simulations

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