Guidelines on the use of irradiated blood components prepared by the British Committee for Standards in Haematology blood transfusion task force

Treleaven, J; Gennery, Andrew R.; Marsh, Judith; Norfolk, D. R.; Page, Lizanne; Parker, Anne; Saran, Frank; Thurston, Jim; Webb, David

doi:10.1111/j.1365-2141.2010.08444.x

Cited by 187 publications

(153 citation statements)

References 60 publications

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“…Of note, the BCSH Blood Transfusion Task Force takes the stance that ''[i]t is not necessary to irradiate red cells for routine 'top-up' transfusions of premature or term infants.'' 10 The BCSH cited the fact that there are few reports of TA-GVHD in preterm and full-term infants 10 ; however, this does not appear to take into account the potential for developing TA-GVHD if a condition that would put the infant at risk has yet to be diagnosed. Other frequently cited indications for irradiation (not queried in 1989) were neonatal exchange transfusions, 1460 of 2202 (66.3%), and intrauterine transfusions, 1344 of 2122 (63.3%).…”

Section: Discussionmentioning

confidence: 99%

“…The evidence used to support these recommendations includes that as of 2011, no cases had been reported in this group in the UK. 10 Some therapies addressed in the 2014 CAP survey were not included in the 1989 AABB survey. Granulocyte transfusions, which are given to neutropenic patients within 24 hours of collection and contain lymphocytes and have been identified as a potential cause of TA-GVHD, were only irradiated per policy in 995 of 2066 organizations (48.2%).…”

Section: Discussionmentioning

confidence: 99%

“…10 Other therapies not included in the AABB survey that have also been identified as potential causes of TA-GVHD are treatment with purine analogue drugs (fludarabine, cladribine, and deoxycoformycin) as well as alemtuzumab (an anti-CD52 agent) and ATG. Purine analog drugs result in profound lymphopenia.…”

Section: Discussionmentioning

confidence: 99%

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Survey of Irradiation Practice for the Prevention of Transfusion-Associated Graft-versus-Host Disease

Pritchard

Shaz²

2016

Archives of Pathology &Amp; Laboratory Medicine

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Context.—Transfusion-associated graft-versus-host disease is a rare, often fatal complication of cellular blood product transfusion. The requirement that at-risk groups receive irradiated products reduces the incidence of transfusion-associated graft-versus-host disease. A comprehensive survey of irradiation practices has not been performed since 1989; meanwhile, new indications for irradiation have emerged. Objective.—To assess current irradiation practices at College of American Pathologists member institutions. Changes in irradiation practice indicated by comparing results of a survey of irradiation practices in 1989 with those of a survey performed in 2014 may reveal how the field has developed and what areas (if any) remain to be improved. Design.—A supplemental College of American Pathologists survey was sent out with questions regarding irradiation practices for specific conditions and circumstances. The questions included conditions for which irradiation is generally considered required for the prevention of transfusion-associated graft-versus-host disease as well as those not considered to be a special risk. Results.—An average of 2100 organizations responded to each question regarding their irradiation practices. Irradiation for transfusion from blood relatives, human leukocyte antigen–matched products, preterm infants, and Hodgkin disease were the most common indications cited. A few organizations had universal irradiation, whereas others irradiated products by floor/unit or by service. Conclusions.—For some at-risk populations irradiation of cellular blood products is more common than in 1989, whereas for others this practice has been reduced. Although gains have been made since the last national survey of irradiation practices, work remains to eliminate the possibility of transfusion-associated graft-versus-host disease from known at-risk populations.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Survey of Irradiation Practice for the Prevention of Transfusion-Associated Graft-versus-Host Disease

Pritchard

Shaz²

2016

Archives of Pathology &Amp; Laboratory Medicine

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“…UK guideline recommends a minimum dose required is 25 Gy with no part should receive more than 50 Gy. They recommended red cells of up to 14-day after collection can be irradiated and stored for at least a further 14 day without significant loss of viability 2,7 . This strict guideline concerns about the quality of the red cell products because it is evidenced that gamma irradiation can cause reduced red cell recovery after transfusion and extracellular potassium level.…”

Section: Methodsmentioning

confidence: 99%

Effects of gamma irradiation on red blood cells at different storage period: A comparative study

Yousuf

Mobin

Subramaniam

et al. 2018

Bangladesh J Med Sci

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Objectives: The objective of this study was to explore the effect of gamma irradiation on the haematological and biochemical parameters of the allogeneic red blood cells units at different storage duration. Methods: A prospective comparative study was conducted at the Blood Bank unit, Department of Diagnostic Laboratory Services of Universiti Kebangsaan Malaysia Medical Centre (UKMMC) in year 2013. Total 36 allogeneic red blood cell units were selected by simple random sampling method and divided into two groups, 18 units in each group based on the storage period into i) up to 14 days and ii) >14 days to expiry. Pre and post irradiation samples were taken immediately before and after irradiation of the units to analyse for the haematological parameters such as plasma Hb level, percent red cell haemolysis, haemoglobin per unit blood (Hb/unit), haematocrit (HCT), red cell indices such as mean corpuscular volume (MCV), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC) and biochemical parameters such as plasma sodium (Na + ), potassium (K + ) and LDH levels. Data was collected and statistical analysis was done. Results: Statistically significant changes were observed between red cell units of up to 14 days and > 14 days old and pre irradiated samples in terms of plasma haemoglobin level, percent red cell haemolysis and plasma Na + , K + and LDH levels. However, pre and post irradiation samples in each group of 14 days and >14 days showed significant changes in the plasma Hb and % haemolysis, Hb/unit, HCT, MCV and MCH in 14 days group while only in plasma Hb, MCV and MCH in >14 days group without any effect on plasma Na + , K + and LDH levels in both group. Conclusion: Comparison at two different red cells storage groups i.e. period of up to 14 days and >14 days, showed significant changes in haematological and biochemical parameters. In the pre irradiation group this reflects the gradual storage changes over time even without going through the irradiation process. On the other hand, the changes between pre and post-irradiation for both the groups of storage showed significant haematological changes indicating irradiation itself also causes significant changes. In view of all these findings, we recommend to irradiate the allogeneic red cell units within 14 days of collection to reduce the adverse effects resulted from irradiation on the cellular products.

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“…All patients had a central venous catheter (CVC) inserted, all received fluoroquinolonebased and anti-fungal prophylaxis from the start of chemotherapy until resolution of neutropenia or introduction of empirical antibiotic therapy for febrile neutropenia. When transfusions were required, blood components were irradiated before infusion [20].…”

Section: Treatment Schedulementioning

confidence: 99%

Fludarabine, Cytarabine and Gentuzumab Ozogamicin (FLA-GO) as Salvage Therapy and Bridge to Transplant in Adult Relapsed Acute Myeloid Leukemia (AML) Patients

Principe¹

2017

Ann Hematol Oncol

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Guidelines on the use of irradiated blood components prepared by the British Committee for Standards in Haematology blood transfusion task force

Cited by 187 publications

References 60 publications

Survey of Irradiation Practice for the Prevention of Transfusion-Associated Graft-versus-Host Disease

Survey of Irradiation Practice for the Prevention of Transfusion-Associated Graft-versus-Host Disease

Effects of gamma irradiation on red blood cells at different storage period: A comparative study

Fludarabine, Cytarabine and Gentuzumab Ozogamicin (FLA-GO) as Salvage Therapy and Bridge to Transplant in Adult Relapsed Acute Myeloid Leukemia (AML) Patients

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