Guidelines on the selection and use of therapeutic products to treat haemophilia and other hereditary bleeding disorders

,

doi:10.1046/j.1365-2516.2003.00711.x

Cited by 109 publications

(6 citation statements)

References 52 publications

(47 reference statements)

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“…Moreover, FFP transfusion was associated with an increased risk of infection and systemic inflammatory response syndrome (39,40), thus, the double strike for the patients with sepsis may not conducive to the recovery of inflammatory response. In addition to TRALI and infection, there are other adverse reactions with the FFP transfusion as follows: allergic reactions, febrile reactions, citrate toxicity, circulatory overload, graft vs. host disease, and inhibitors against deficient proteins (41)(42)(43). As we can imagine, the FFP transfusion may not conducive to survival on the patients with sepsis when the effects of adverse reactions play a dominant role.…”

Section: Discussionmentioning

confidence: 99%

Early Fresh Frozen Plasma Transfusion: Is It Associated With Improved Outcomes of Patients With Sepsis?

et al. 2021

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Background: So far, no study has investigated the effects of plasma transfusion in the patients with sepsis, especially in the terms of prognosis. Therefore, we aimed to explore the association of early fresh frozen plasma (FFP) transfusion with the outcomes of patients with sepsis.Methods: We performed a cohort study using data extracted from the Medical Information Mart for Intensive Care III database (v1.4). External validation was obtained from the First Affiliated Hospital of Wenzhou Medical University, China. We adopted the Sepsis-3 criteria to extract the patients with sepsis and septic shock. The occurrence of transfusion during the first 3-days of intensive care unit (ICU) stay was regarded as early FFP transfusion. The primary outcome was 28-day mortality. We assessed the association of early FFP transfusion with the patient outcomes using a Cox regression analysis. Furthermore, we performed the sensitivity analysis, subset analysis, and external validation to verify the true strength of the results.Results: After adjusting for the covariates in the three models, respectively, the significantly higher risk of death in the FFP transfusion group at 28-days [e.g., Model 2: hazard ratio (HR) = 1.361, P = 0.018, 95% CI = 1.054–1.756] and 90-days (e.g., Model 2: HR = 1.368, P = 0.005, 95% CI = 1.099–1.704) remained distinct. Contrarily, the mortality increased significantly with the increase of FFP transfusion volume. The outcomes of the patients with sepsis with hypocoagulable state after early FFP transfusion were not significantly improved. Similar results can also be found in the subset analysis of the septic shock cohort. The results of external validation exhibited good consistency.Conclusions: Our study provides a new understanding of the rationale and effectiveness of FFP transfusion for the patients with sepsis. After recognizing the evidence of risk-benefit and cost-benefit, it is important to reduce the inappropriate use of FFP and avoid unnecessary adverse transfusion reactions.

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Section: Discussionmentioning

confidence: 99%

Early Fresh Frozen Plasma Transfusion: Is It Associated With Improved Outcomes of Patients With Sepsis?

et al. 2021

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“…When treatment is required, recombinant products, if available, should be regarded as the products of choice to avoid the potential risk of viral transmission. 24 Desmopressin, a synthetic analogue of the antidiuretic hormone vasopressin, increases the plasma concentration of FVIII and VWF through endogenous release. [25][26][27] It is effective in selective cases and has the advantage of avoiding the risks of bloodborne viral infection.…”

Section: Labour and Deliverymentioning

confidence: 99%

Management of women with inherited bleeding disorders in pregnancy

Chi

Kadir

2007

The Obstetric & Gynaecologis

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Key content Pregnancy in women with inherited bleeding disorders requires specialised and individualised care using a multidisciplinary approach with obstetricians, midwives, haematologists and anaesthetists. Childbirth presents an intrinsic haemostatic challenge in these women and obstetricians may be the first to encounter haemorrhagic complications. An understanding and awareness of these disorders and close collaboration between obstetricians and haematologists are essential in ensuring a successful outcome. Learning objectives To understand the basic principles in the obstetric management of women with inherited bleeding disorders. To know the options available for prenatal diagnosis. To be aware of the increased risk of haemorrhagic complications in these women and their offspring. Ethical issues Advances in prenatal diagnosis and treatment of inherited bleeding disorders create complex dilemmas for families affected by these disorders. Please cite this article as: Chi C, Kadir RA. Management of women with inherited bleeding disorders in pregnancy. The Obstetrician & Gynaecologist 2007;9:27–33.

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Section: Discussionmentioning

confidence: 99%

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Guidelines on the selection and use of therapeutic products to treat haemophilia and other hereditary bleeding disorders

Cited by 109 publications

References 52 publications

Early Fresh Frozen Plasma Transfusion: Is It Associated With Improved Outcomes of Patients With Sepsis?

Early Fresh Frozen Plasma Transfusion: Is It Associated With Improved Outcomes of Patients With Sepsis?

Management of women with inherited bleeding disorders in pregnancy

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