Guidelines of the French Society of Otorhinolaryngology (SFORL), short version. Extension assessment and principles of resection in cutaneous head and neck tumors

Durbec, M.; Couloigner, V.; Tronche, Sophie; Albert, S.; Kanitakis, Jean; Boudrigua, A. Ltaief; Malard, O.; Maubec, Ève; Langlois, Èmmanuel; Navailles, B.; Peuvrel, L.; Phulpin, Bérengère; Thimonier, J.; Disant, F.; Dolivet, Gilles

doi:10.1016/j.anorl.2014.06.002

Cited by 17 publications

(8 citation statements)

References 64 publications

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“…Due to its rarity, there is limited information on the management and prognosis of temporal bone angiosarcoma. Management may be based on treatment paradigms for soft tissue sarcoma, which is a heterogeneous group of tumors . The pathogenesis of angiosarcoma in the unirradiated temporal bone is mysterious, but similarities to the development of squamous cell carcinoma in the setting of chronic otitis media can be drawn .…”

Section: Discussionmentioning

confidence: 99%

“…In the calvarium, outcomes may be worse because of the inability to perform complete resections and the proximity of the brain/meninges. In general, surgery is the primary treatment recommended with adjuvant radiation . Adjuvant chemotherapy (taxanes, doxorubicin) is not standard therapy, but may be useful for high‐risk tumors.…”

Section: Discussionmentioning

confidence: 99%

“…Management may be based on treatment paradigms for soft tissue sarcoma, which is a heterogeneous group of tumors. 6,8,9 The pathogenesis of angiosarcoma in the unirradiated temporal bone is mysterious, but similarities to the development of squamous cell carcinoma in the setting of chronic otitis media can be drawn. 10 The presence of a chronic inflammatory environment that promotes malignant transformation could be postulated.…”

Section: Discussionmentioning

confidence: 99%

“…In general, surgery is the primary treatment recommended with adjuvant radiation. 8 Adjuvant chemotherapy (taxanes, doxorubicin) is not standard therapy, but may be useful for high-risk tumors. Bevacizumab has also been studied, as there is increased expression of vascular endothelial growth factor (VEGF) and VEGF receptors in angiosarcomas.…”

Section: Discussionmentioning

confidence: 99%

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Otopathology in Angiosarcoma of the Temporal Bone

et al. 2018

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Objectives/Hypothesis Investigate the otopathology of angiosarcoma of the temporal bone, which has not been previously described in the literature. Study Design Postmortem evaluation and literature review. Methods Postmortem histological evaluation of the temporal bones and review of the literature for the treatment and prognosis of this rare disease were performed. Results A 50‐year‐old male with right chronic otitis media presented with progressive hearing loss, disequilibrium, otalgia, and acute facial paresis. Biopsy of the external auditory canal was unrevealing, but specimens from a canal wall down tympanomastoidectomy later showed high‐grade angiosarcoma. Magnetic resonance imaging demonstrated an unresectable middle ear and mastoid mass extending superiorly into the temporal lobe. The patient received induction chemotherapy followed by proton beam radiation therapy and concurrent paclitaxel and bevacizumab. His course was complicated by a cerebrospinal fluid leak and cauda equina syndrome from leptomeningeal sarcomatosis. The patient died after developing meningitis and a temporal lobe abscess. Postmortem otopathology revealed persistent angiosarcoma in the internal auditory canal, although none was found in the middle ear or mastoid. There was inflammatory infiltrate throughout the mastoid, with direct extension of neutrophils and bacteria into the cochlea and through the tegmen into the middle cranial fossa. Conclusions Angiosarcoma of the temporal bone can arise in the setting of chronic otitis media. In this case, postmortem temporal bone sections demonstrated viable cancer despite chemoradiation. Inflammatory infiltrates crossing from the middle ear/mastoid into the labyrinth and central nervous system illustrate pathways for the development of otogenic meningitis. Level of Evidence 4 Laryngoscope, 129:737–742, 2019

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Otopathology in Angiosarcoma of the Temporal Bone

et al. 2018

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“…Th e British Society for Dermatological Surgery position statement on the management of DFSP states that Mohs surgery is the initial treatment of choice for DSFP ( 4 ). Th e French Society of Otorhinolaryngology guidelines recommends Mohs surgery for the treatment of head and neck DFSP ( 5 ). Comparisons of Mohs surgery with wide local excision for treatment of DFSP have shown Mohs surgery to be superior in terms of lower recurrence rate ( 6 -9 ).…”

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confidence: 99%