Guidelines in the management of Helicobacter pylori infection in Japan

Kato, Mototsugu; Shimizu, Yuichi; Takeda, Hiroshi; Sugiyama, Toshiro; Asaka, Masahiro

doi:10.1007/978-94-017-1763-2_54

Cited by 58 publications

(73 citation statements)

References 26 publications

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“…In the case of gastric cancers, eradication of H. pylori is the primary strategy for prevention (47), but the incidence of gastric cancers remains high, even after H. pylori eradication, especially in persons with intestinal metaplasia and gastric atrophy (48). Notably, aberrant methylation in gastric mucosae decreases by H. pylori eradication, but it does not disappear completely (14,49).…”

Section: Discussionmentioning

confidence: 99%

Prevention of Helicobacter pylori–Induced Gastric Cancers in Gerbils by a DNA Demethylating Agent

Niwa

Toyoda

Tsukamoto

et al. 2013

Cancer Prevention Research

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Suppression of aberrant DNA methylation is a novel approach to cancer prevention, but, so far, the efficacy of the strategy has not been evaluated in cancers associated with chronic inflammation. Gastric cancers induced by Helicobacter pylori infection are known to involve aberrant DNA methylation and associated with severe chronic inflammation in their early stages. Here, we aimed to clarify whether suppression of aberrant DNA methylation can prevent H. pylori-induced gastric cancers using a Mongolian gerbil model. Administration of a DNA demethylating agent, 5-aza-2 0 -deoxycytidine (5-aza-dC), to gerbils (0.125 mg/kg for 50-55 weeks) decreased the incidence of gastric cancers induced by H. pylori infection and N-methyl-N-nitrosourea (MNU) treatment from 55.2% to 23.3% (P < 0.05). In gastric epithelial cells, DNA methylation levels of six CpG islands (HE6, HG2, SB1, SB5, SF12, and SH6) decreased to 46% to 68% (P < 0.05) of gerbils without 5-aza-dC treatment. Also, the global DNA methylation level decreased from 83.0% AE 4.5% to 80.3% AE 4.4% (mean AE SD) by 5-aza-dC treatment (P < 0.05). By 5-aza-dC treatment, Il1b and Nos2 were downregulated (42% and 58% of gerbils without, respectively) but Tnf was upregulated (187%), suggesting that 5-aza-dC treatment induced dysregulation of inflammatory responses.No obvious adverse effect of 5-aza-dC treatment was observed, besides testicular atrophy. These results showed that 5-aza-dC treatment can prevent H. pylori-induced gastric cancers and suggested that removal of induced DNA methylation and/or suppression of DNA methylation induction can become a target for prevention of chronic inflammation-associated cancers. Cancer Prev Res; 6(4); 263-70. Ó2013 AACR.

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Section: Discussionmentioning

confidence: 99%

Prevention of Helicobacter pylori–Induced Gastric Cancers in Gerbils by a DNA Demethylating Agent

Niwa

Toyoda

Tsukamoto

et al. 2013

Cancer Prevention Research

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“…After eradication of H. pylori, the status of H. pylori infection was determined by H. pylori culture or 13 C-urea breath test at intervals ranging from 1 month to 12 months according to the guidelines for the management of H. pylori infections in Japan [22].…”

Section: Examination Of H Pylori Infectionmentioning

confidence: 99%

Pathophysiological Investigation of the Gastric Surface Mucous Gel Layer of Patients with Helicobacter pylori Infection by Using Immunoassays for Trefoil Factor Family 2 and Gastric Gland Mucous Cell-Type Mucin in Gastric Juice

et al. 2011

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“…Other authors, like Malfertheiner and collaborators or in the Maastrischt III (2007) consensus, report superior results which places it closer to the gold standard which is the histological study in any of its variants (sensibility of 90-93% and specificity of 95-99%) (23,24).…”

Section: Discussionmentioning

confidence: 89%

Chromoendoscopy with red phenol in the diagnosis of Helicobacter pylori infection

Hernández‐Garcés¹,

Castellanos-González²,

González-Fabián

et al. 2012

Rev. esp. enferm. dig.

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An analytic study to validate a diagnostic test was carried out at the Institute of Gastroenterology in Havana, Cuba in adult patients of both sexes in whom chromoendoscopy was carried out with red phenol at 0.1% over the gastric mucosa for the detection of Helicobacter pylori infection between November 2008 and December 2010. The staining with red phenol at 0.1% is included in the invasive tests for the diagnosis of Helicobacter pylori infection and of the reactive techniques. The sensibility of red phenol dye in the diagnosis of Helicobacter pylori infection in the patients studied was of 72.6% with a confidence interval (C.I.) of 95% (64.9 to 79.2%) and a specificity of 75.5% C.I. 95% (61.9 to 85.4%). The positive predictive value was of 89.8% C.I. 95% (83.1 to 94.1%) and the negative predictive value of 48.1% C.I. 95% (37.3 to 59.0%). The proportion of false positives was of 24.5% C.I. 95% (14.6 to 38.1%) and the proportion of false negatives was of 27.4% C.I. 95% (20.8 to 35.1%). The diagnostic accuracy of the dye on the patients studied was 73.3% C.I. 95% (66.7 to 79.0%). The diagnostic odds ratio was 8.17 C.I. 95% (3.88 to 17.23), the J Youden ratio of 0.5 and the Kappa coefficient of 0.40 C.I. 95% (0.27 to 0.54). The staining dye with red phenol at 0.1% resulted in a useful method in the diagnosis of Helicobacter pylori infection in the gastric mucosa, it can be applied in our environment and has multiple advantages (topographic localization, avoids contamination and fast and immediate reading).

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Guidelines in the management of Helicobacter pylori infection in Japan

Cited by 58 publications

References 26 publications

Prevention of Helicobacter pylori–Induced Gastric Cancers in Gerbils by a DNA Demethylating Agent

Prevention of Helicobacter pylori–Induced Gastric Cancers in Gerbils by a DNA Demethylating Agent

Pathophysiological Investigation of the Gastric Surface Mucous Gel Layer of Patients with Helicobacter pylori Infection by Using Immunoassays for Trefoil Factor Family 2 and Gastric Gland Mucous Cell-Type Mucin in Gastric Juice

Chromoendoscopy with red phenol in the diagnosis of Helicobacter pylori infection

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