Guidelines for uveal melanoma: a critical appraisal of systematically identified guidelines using the AGREE II and AGREE-REX instrument

Steeb, Theresa; Hayani, Kinan; Förster, Paul; Liegl, Raffael; Toussaint, Frédéric; Schlaak, Max; Berking, Carola; Heppt, Markus V.

doi:10.1007/s00432-020-03141-w

Cited by 20 publications

(18 citation statements)

References 30 publications

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“…Then, six independent reviewers (A.W., F.H., A.H., M.K., E.K., F.T.) evaluated their methodological quality using AGREE II and AGREE-REX as described previously [ 16 ]. Using AGREE II, the quality of each of the 23 items was assessed on a 7-point scale ranging from 1 (”strongly disagree”) to 7 (“strongly agree”) and similarly, the guideline’s overall quality was evaluated on a 7-point scale ranging from lowest to highest possible quality.…”

Section: Methodsmentioning

confidence: 99%

“…Furthermore, the question “I would recommend this guideline for use” was answered by each reviewer with “yes”, “yes, with modifications” or “no”. The 9 items supplied by AGREE-REX were also assessed on a 7-point scale ranging from 1 (“lowest quality”) to 7 (“highest quality”) as described previously [ 16 ]. All evaluations using AGREE II and AGREE-REX were blinded towards the other evaluators’ assessments and performed independently.…”

Section: Methodsmentioning

confidence: 99%

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A Critical Appraisal of Evidence- and Consensus-Based Guidelines for Actinic Keratosis

et al. 2021

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Actinic keratoses (AK) are common lesions of the skin that can be effectively treated with several lesion- and field-directed treatments. Clinical practice guidelines assist physicians in choosing the appropriate treatment options for their patients. Here, we aimed to systematically identify and evaluate the methodological quality of currently available guidelines for AK. Guidelines published within the last 5 years were identified in a systematic search of guideline databases, Medline and Embase. Then, six independent reviewers evaluated the methodological quality using the tools “Appraisal of Guidelines for Research and Evaluation” (AGREE II) and “Recommendation EXcellence” (AGREE-REX). The Kruskal–Wallis (H) test was used to explore differences among subgroups and Spearman’s correlation to examine the relationship between individual domains. Three guidelines developed by consortia from Canada, Germany and the United Kingdom were eligible for the evaluation. The German guideline achieved the highest scores, fulfilling 65 to 92% of the criteria in AGREE II and 67 to 84% in AGREE-REX, whereas the Canadian guideline scored 31 to 71% of the criteria in AGREE II and 33 to 46% in AGREE-REX. The domains “stakeholder involvement“ and “values and preferences“ were identified as methodological weaknesses requiring particular attention and improvement in future guideline efforts.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

A Critical Appraisal of Evidence- and Consensus-Based Guidelines for Actinic Keratosis

et al. 2021

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“…independently collected relevant information on each guideline, including title, national authority/author and country of origin, publication date, methodological approach and its scope. Five independent reviewers assessed the methodological quality of each guideline identified in the search using the evaluation tools AGREE II and AGREE-REX as recently described by the authors [40].…”

Section: Data Extraction and Rating Of The Guidelinesmentioning

confidence: 99%

The Quality of Practice Guidelines for Melanoma: A Methodologic Appraisal with the AGREE II and AGREE-REX Instruments

Steeb

Wessely

Drexler

et al. 2020

Cancers

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Multiple guidelines on cutaneous melanoma (CM) are available from several consortia and countries. To provide up-to-date guidance in the rapidly changing field of melanoma treatment, guideline developers have to provide regular updates without compromises of quality. We performed a systematic search in guideline databases, Medline and Embase to identify guidelines on CM. The methodological quality of the identified guidelines was independently assessed by five reviewers using the instruments “Appraisal of Guidelines for Research and Evaluation” (AGREE II) and “Recommendation EXcellence” (AGREE-REX). We performed descriptive analysis, explored subgroup differences using the Kruskal–Wallis (H) test and examined the relationship between distinct domains and items of the instruments with Spearman’s correlation. Six guidelines by consortia from Australia, France, Germany, Scotland, Spain and the United States of America were included. The German guideline fulfilled 71%–98% of criteria in AGREE II and 78%–96% for AGREE-REX, obtaining the highest scores. Deficiencies in the domains of “applicability” and “values and preferences” were observed in all guidelines. The German and Spanish guidelines significantly differed from each other in most of the domains. The domains “applicability” and “values and preferences” were identified as methodological weaknesses requiring careful revision and improvement in the future.

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“…In relation to the treatment of UM metastasis, Mariani P [16], in 2012, advocated to resect metastatic foci, which was put forward on the premise of a lack of effective target molecule therapies, and in fact it is still a palliative therapy. The 2015 UK UM guidelines [17] and the 2020 Irish and German UM guidelines [18] contained no target therapies, and there are no FDA-approved UM target molecule therapeutic drugs in the USA, indicating that this research has not o cially been carried out clinically anywhere in the world. The reason for this is that although UM is clinically and biologically different from cutaneous melanoma (CM), most of the treatment options for advanced stage UM can refer to CM.…”

Section: Discussionmentioning

confidence: 99%

Proteomics Analysis: Inhibiting the Expression of P62 Protein by Chloroquine Combined with Dacarbazine Can Reduce the Malignant Progression of Uveal Melanoma

Fei

Xie

Qin³

et al. 2021

Preprint

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Background: Although uveal melanoma (UM) at the early stage is controllable to some extent, it inevitably ultimately leads to death due to widespread metastasis to the entire body. At present, the difficulty is that there is no way to effectively tackle the metastasis. It is hypothesized that these will be treated by target molecules, but the recognized target molecule has not yet been found. In this study, the target molecule was explored through proteomics.Methods: Transgenic enhanced green fluorescent protein (EGFP) inbred nude mice, which spontaneously display a tumor microenvironment (TME), were used as model animal carriers. The UM cell line 92.1 was inoculated into the brain ventricle stimulating metastatic growth of UM, and a graft re-cultured Next, the UM cell line 92.1-A was obtained through monoclonal amplification, and a differential proteomics database, between 92.1 and ectopic 92.1-A, was established. Finally, bioinformatics methodologies were adopted to optimize key regulatory proteins, and in vivo and in vitro functional verification and targeted drug screening were performed. Results: Cells and tissues displaying green fluorescence in animal models were determined as TME characteristics provided by hosts. The data of various biological phenotypes detected proved that 92.1-A were more malignant than 92.1. Besides this malignancy, p62 protein, selected from 5267 quantifiable differential proteomics databases, was a multifunctional autophagy linker protein, and its expression could be suppressed by chloroquine and dacarbazine that are commonly applied in clinics. Inhibition of p62 could reduce the malignancy degree of metastatic UM. Conclusion: As the carriers of human UM orthotopic and ectopic xenotransplantation, transgenic EGFP inbred nude mice clearly display the characteristics of TME. In addition, the p62 protein optimized by the proteomics is the key protein that increases the malignancy of 92.1 cells, which therefore provides a basis for further exploration of target molecule therapy for refractory metastatic UM.

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Guidelines for uveal melanoma: a critical appraisal of systematically identified guidelines using the AGREE II and AGREE-REX instrument

Cited by 20 publications

References 30 publications

A Critical Appraisal of Evidence- and Consensus-Based Guidelines for Actinic Keratosis

A Critical Appraisal of Evidence- and Consensus-Based Guidelines for Actinic Keratosis

The Quality of Practice Guidelines for Melanoma: A Methodologic Appraisal with the AGREE II and AGREE-REX Instruments

Proteomics Analysis: Inhibiting the Expression of P62 Protein by Chloroquine Combined with Dacarbazine Can Reduce the Malignant Progression of Uveal Melanoma

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