Guidelines for the use of Animals in Biomedical Research

Giles, Alan R.

doi:10.1055/s-0038-1646066

Cited by 248 publications

(162 citation statements)

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“…40, 18 Feb. 1992) and international laws and policies (NIH Guide for the Care and Use of Laboratory Animals, NIH Publication no. 1985 12, 1987;Giles, 1987).…”

Section: Animalsmentioning

confidence: 99%

Galactosylated polymeric carriers for liver targeting of sorafenib

Craparo

Sardo

Serio

et al. 2014

International Journal of Pharmaceutics

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“…40, 18 Feb. 1992) and international laws and policies (NIH Guide for the Care and Use of Laboratory Animals, NIH Publication no. 1985 12, 1987;Giles, 1987).…”

Section: Animalsmentioning

confidence: 99%

Galactosylated polymeric carriers for liver targeting of sorafenib

Craparo

Sardo

Serio

et al. 2014

International Journal of Pharmaceutics

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“…The animal studies were conducted to conform to the guiding principles of the International Society for Thrombosis and Haemostasis. 41 …”

Section: Study Groupsmentioning

confidence: 99%

Time course of the effects of a single bolus injection of F(ab')2 fragments of the antiplatelet GPIIb/IIIa antibody 7E3 on arterial eversion graft occlusion, platelet aggregation, and bleeding time in dogs.

Kiss

Lü

Roskams

et al. 1994

Arterioscler Thromb

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“…26 For the study of platelet-assisted leukocyte rolling over the endothelial surface of blood vessels in vivo, online video microscopy was performed in C57/Bl6 mice. Healthy wild-type (WT) mice (6 to 12 weeks old) were anesthetized with Nembutal (70 mg/kg IP), and the jugular vein was catheterized.…”

Section: In Vivo Inhibition Of Endothelial Cell Inflammationmentioning

confidence: 99%

Gallic Acid Antagonizes P-Selectin–Mediated Platelet–Leukocyte Interactions

et al. 2005

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Background-Current paradigm attributes the low incidence of cardiovascular disorders in Mediterranean countries despite a high saturated fat intake, the "French paradox," to the antioxidant capacity of red wine polyphenols.Conceivably, other antiinflammatory pathways may contribute to at least a similar extent to the atheroprotective activity of these polyphenols. We have investigated whether gallic acid (GA), an abundant red wine polyphenol, modulates the activity of P-selectin, an adhesion molecule that is critically involved in the recruitment of inflammatory cells to the vessel wall and thus in atherosclerosis. Methods and Results-GA potently inhibited the binding of a peptide antagonist (IC 50 , 7.2 mol/L) and biotin-PAA-Le a -SO 3 H, an established high-affinity ligand, to P-selectin (IC 50 , 85 mol/L). Under dynamic flow conditions, GA markedly and dose dependently attenuated the rolling of monocytic HL60 cells over P-selectin-transfected Chinese hamster ovary cells (EC 50 , 14.5 mol/L) while increasing the velocity of P-selectin-dependent rolling of human blood leukocytes over a platelet monolayer. In vivo tests established that GA administration to normolipidemic C57/Bl6 and aged atherosclerotic apolipoprotein E-deficient mice impaired the baseline rolling of conjugates between activated platelets and circulating monocytes over femoral vein endothelium, as judged by online video microscopy (ED 50 , 1.7Ϯ0.3 and 1.5Ϯ0.4 mg · kg Ϫ1 · h Ϫ1 , respectively). Conclusions-Our findings provide a solid mechanistic foundation through which GA intervenes in major inflammatory pathobiologies by binding and antagonizing P-selectin.

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Guidelines for the use of Animals in Biomedical Research

Cited by 248 publications

References 0 publications

Galactosylated polymeric carriers for liver targeting of sorafenib

Galactosylated polymeric carriers for liver targeting of sorafenib

Time course of the effects of a single bolus injection of F(ab')2 fragments of the antiplatelet GPIIb/IIIa antibody 7E3 on arterial eversion graft occlusion, platelet aggregation, and bleeding time in dogs.

Gallic Acid Antagonizes P-Selectin–Mediated Platelet–Leukocyte Interactions

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