Guidelines for the Use of Acitretin in Psoriasis

Carretero, G.; Ribera, M.; Belinchón, I.; Carrascosa, J.M.; Puig, L.; Ferrándiz, Carlos; Dehesa, Luis; Vidal, David; Peral, Fernando Zamanillo; Jorquera, E.; Gonzalez-Quesada, A.; Muñoz, César Velasco; Notario, J.; Vanaclocha, F.; Moreno, J.C.

doi:10.1016/j.adengl.2013.01.001

Cited by 40 publications

(53 citation statements)

References 122 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several case reports and series illustrate the usefulness of acitretin in case of suboptimal results of biological therapy. In such situations, it can indeed enhance the clinical result without adding immunosuppressive effects [28]. This treatment was inefficient in our case in monotherapy.…”

Section: Discussionmentioning

confidence: 99%

Acrodermatitis Continua of Hallopeau Treated Successfully with Ustekinumab and Acitretin after Failure of Tumour Necrosis Factor Blockade and Anakinra

Saunier¹,

Debarbieux²,

Jullien

et al. 2014

Dermatology

View full text Add to dashboard Cite

Acrodermatitis continua of Hallopeau (ACH) is a rare form of chronic acral pustular eruption. Considered to be a variant of pustular psoriasis, it is a refractory condition that may not respond to conventional treatments. We report herein the case of a 53-year-old patient whose ACH was refractory to all conventional systemic treatment modalities and to anti-tumour necrosis factor. Because he had increased plasma levels of interleukin (IL)-1β, he received anakinra for 7 weeks, without further improvement however. Achievement of complete response was obtained with ustekinumab 90 mg s.c. every 12 weeks combined with acitretin; the plasma level of IL-1β concomitantly returned to normal. This case report is associated with a review on recent data on ACH treatment with biological agents, including anakinra and ustekinumab.

show abstract

Section: Discussionmentioning

confidence: 99%

Acrodermatitis Continua of Hallopeau Treated Successfully with Ustekinumab and Acitretin after Failure of Tumour Necrosis Factor Blockade and Anakinra

Saunier¹,

Debarbieux²,

Jullien

et al. 2014

Dermatology

View full text Add to dashboard Cite

show abstract

“…Acitretin is used orally in patients with severe and erythrodermic psoriasis vulgaris resistant to other therapies, generalized and localized pustular psoriasis, severe congenital ichthyosis, Darier's disease, pityriasis rubra piliaris, recalcitrant lichen planus and palmoplantar keratoderma (1,7,8). Alitretinoin is effective in severe chronic hand eczema (5,8).…”

mentioning

confidence: 99%

Side effects of retinoid therapy on the quality of vision

Bergler‐Czop

Bilewicz-Stebel²,

Stańkowska³

et al. 2016

Acta Pharmaceutica

View full text Add to dashboard Cite

Retinoids are compounds chemically related to vitamin A, which are frequently used in dermatological practice (1). They are characterized by numerous mechanisms of action leading to normalization of keratinocyte proliferation and maturation. They have anti-seborrhoeic, immunomodulatory and anti-inflammatory effects (1, 2). A number of side effects to retinoid treatment have been recorded; one group of such side effects relates to eyes and vision. Dry eye syndrome and blepharoconjunctivitis are the most common side effects, appearing in 20-50 % of patients treated with retinoids. They often contribute to the occurrence of other side-effects such as eye discomfort and contact lens intolerance. Due to the widespread use in clinical practice, the adverse effects, including ocular side effects, should be studied. To confirm the variety of adverse effects of retinoids, several case reports of rare side-effects are presented.

show abstract

“…A recent study of 368 patients with psoriasis found that the dermatologist had detected at least 1 previously undiagnosed CVRF in 27% of these patients by simply taking these two steps. 31 It is also important to bear in mind that some psoriasis treatments can affect CVRFs, 32,33 and that obesity can alter the response to biologics because the effects of drugs administered at fixed doses may be attenuated in heavier patients. 34 We must underline the limitations of the AQUILES study.…”

Section: Discussionmentioning

confidence: 99%