Guidelines for the Study of Nonspecific Bronchial Hyperresponsiveness in Asthma

Tordera, Miguel Perpiñá; Río, Francisco García; Gutiérrez, Francisco Javier Álvarez; Serrano, Carolina Cisneros; Torrero, Luis Compte; Costa, Luis Manuel Entrenas; Moreno, Carlos Melero; Nieto, María Jesús Rodríguez; Fernández, Alfons Torrego

doi:10.1016/j.arbr.2013.07.001

Cited by 8 publications

(6 citation statements)

References 109 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The reference values used were those proposed for the Mediterranean population 10. Bronchial challenge with methacholine was performed in accordance with Spanish guidelines 11. Briefly, a Mefar MB3 (Mefar, Ele H2O, Medicalli, Brescia, Italy) dosimeter was used, and increasing concentrations of methacholine (from 0.03 mg/mL to 16 mg/mL) were inhaled at 3-minute intervals until Forced Expiratory Volume in the first second (FEV 1 ) had fallen by 20% compared with its baseline value or until the subject had inhaled the maximum concentration of methacholine.…”

Section: Methodsmentioning

confidence: 99%

Specific inhalation challenge: the relationship between response, clinical variables and lung function

Cruz²,

Ojanguren³

et al. 2017

Occup Environ Med

View full text Add to dashboard Cite

show abstract

Section: Methodsmentioning

confidence: 99%

Specific inhalation challenge: the relationship between response, clinical variables and lung function

Cruz²,

Ojanguren³

et al. 2017

Occup Environ Med

View full text Add to dashboard Cite

show abstract

“…Asthma is one of the most frequent chronic diseases in childhood . Airway hyperresponsiveness (AHR) is a key feature of asthma and a highly important factor when detecting the disease during nonspecific bronchial challenge …”

Section: Introductionmentioning

confidence: 99%

“…A bronchial challenge test consists of inducing bronchoconstriction and measuring the resulting changes in lung function. Of all the indexes measured, a decrease in forced expiratory volume in 1 second (FEV1) from baseline is the gold standard to determine positive test results . However, forced expiratory maneuvers are usually difficult in young children because the procedure requires active cooperation, and obtaining reproducible flow‐volume curves throughout all stages of the test can be an arduous task.…”

Section: Introductionmentioning

confidence: 99%

Comparison of impulse oscillometry and spirometry for detection of airway hyperresponsiveness to methacholine, mannitol, and eucapnic voluntary hyperventilation in children

Jara-Gutierrez

Aguado

Potro

et al. 2019

Pediatric Pulmonology

View full text Add to dashboard Cite

Background Forced expiratory maneuvers are usually difficult in young children. Impulse oscillometry (IOS) requires no active cooperation, is noninvasive, rapid, and easy to perform. This study aimed to compare IOS indexes and forced expiratory volume in 1 second (FEV1) in children for the assessment of bronchial hyperreactivity to methacholine, mannitol, and eucapnic voluntary hyperventilation (EVH). Materials Children aged 3‐14 years (mean 10.0 ± 3.1) with symptoms suggestive of asthma were recruited. IOS measurements were taken before spirometry. Methacholine, mannitol, and EVH tests were performed without a specific order. Results We included 190 children, whose mean age was 10.0 ± 3.1 years. Changes in FEV1 correlated significantly with variation in IOS indexes (P < .05). The indexes with the greatest discriminative capacity were Z5, R5, and X5. Optimal cut‐offs were: for methacholine tests, ≧22% in R5, ≧82% for reactance area (AX), and ≦41% for X5; for the mannitol test, ≧18% in R5, ≧40% in AX, and ≦21% for X5. In the EVH test, ≧23% for R5, ≧40% for AX, and a fall of 29% for X5. When using the optimal cut‐off points obtained from IOS, the mean number of steps and doses required for methacholine and mannitol tests to induce significant bronchoconstriction were significantly lower compared with spirometry ( P < .05). Conclusions The effectiveness of R5, X5, and AX indexes were comparable to FEV1 in assessing bronchial obstruction during bronchial challenge testing. Therefore, IOS may be useful in assessing bronchial obstruction in children who cannot reliably perform spirometric maneuvers during bronchial challenge testing.

show abstract

“…Bronchial hyperresponsiveness (BH) in asthma is a condition in which the airway lumen narrows excessively in response to physical or chemical stimuli, such as HS (hypersaline) aerosols. In healthy patients, airways result in little or no caliber reduction when stimulated [16]. For this reason, HT has been used as a bronchial challenge agent for diagnosing asthma as an alternative to other airway stimulation agents such as direct mediators (histamine, methacholine) or physical exercise.…”

Section: Diagnosis: Clinical Utilitymentioning

confidence: 99%

Halotherapy—An Ancient Natural Ally in the Management of Asthma: A Comprehensive Review

et al. 2021

View full text Add to dashboard Cite

The increasing production of modern medication emerges as a new source of environmental pollution. The scientific community is interested in developing alternative, ecological therapies in asthma. Halotherapy proved its benefits in asthma diagnosis, treatment, and prevention and may represent a reliable therapeutic addition to the allopathic treatment, due to its ecological and environment-friendly nature, in order to prevent or prolong the time to exacerbations in patients with asthma. We aimed to review up-to-date research regarding halotherapy benefits in asthma comprehensively. We searched the electronic databases of PubMed, MEDLINE, EMBASE for studies that evaluated the exposure of asthmatic patients to halotherapy. Eighteen original articles on asthma were included. Five studies in adults and five in children assessed the performance of hypertonic saline bronchial challenges to diagnose asthma or vocal cord dysfunction in asthmatic patients. Three papers evaluated the beneficial effects of halotherapy on mucociliary clearance in asthmatic adults. The therapeutic effect of halotherapy on acute or chronic asthma was appraised in three studies in adults and one in children. The preventive role was documented in one paper reporting the ability of halotherapy to hinder nocturnal asthma exacerbations. All studies seem to sustain the overall positive effects of halotherapy as adjuvant therapy on asthma patients with no reported adverse events. Halotherapy is a crucial natural ally in asthma, but further evidence-based studies on larger populations are needed.

show abstract

Guidelines for the Study of Nonspecific Bronchial Hyperresponsiveness in Asthma

Cited by 8 publications

References 109 publications

Specific inhalation challenge: the relationship between response, clinical variables and lung function

Specific inhalation challenge: the relationship between response, clinical variables and lung function

Comparison of impulse oscillometry and spirometry for detection of airway hyperresponsiveness to methacholine, mannitol, and eucapnic voluntary hyperventilation in children

Halotherapy—An Ancient Natural Ally in the Management of Asthma: A Comprehensive Review

Contact Info

Product

Resources

About