Guidelines for the number of embryos to transfer following in vitro fertilization

Sogc-Cfas, Joint

doi:10.1016/j.ijgo.2008.01.007

Cited by 55 publications

(6 citation statements)

References 145 publications

(269 reference statements)

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“…Indeed, there has been a resurgence of interest in NC-IVF for all patients in recent years because it avoids COH and its potential sequelae. Moreover, this also supports the international drive to reduce multiple pregnancies rates with elective single embryo transfer and to minimise complications such as OHSS [ 28 – 30 ]. Pelinck et al [ 1 ] conducted a systematic review of 1,800 natural IVF cycles reported between 1989 and 2000 and concluded that NC-IVF has a pregnancy rate of less than 10% per cycle.…”

Section: Introductionsupporting

confidence: 55%

Impact of Exogenous Gonadotropin Stimulation on Circulatory and Follicular Fluid Cytokine Profiles

Baskind

Orsi

Sharma

2014

International Journal of Reproductive Medicine

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Background. The natural cycle is the prototype to which we aspire to emulate in assisted reproduction techniques. Increasing evidence is emerging that controlled ovarian hyperstimulation (COH) with exogenous gonadotropins may be detrimental to oogenesis, embryo quality, and endometrial receptivity. This research aimed at assessing the impact of COH on the intrafollicular milieu by comparing follicular fluid (FF) cytokine profiles during stimulated in vitro fertilization (IVF) and modified natural cycle (MNC) IVF. Methods. Ten women undergoing COH IVF and 10 matched women undergoing MNC IVF were recruited for this pilot study. 40 FF cytokine concentrations from individual follicles and plasma were measured by fluid-phase multiplex immunoassay. Demographic/cycle/cytokine data were compared and correlations between cytokines were computed. Results. No significant differences were found between COH and MNC groups for patient and cycle demographics, including outcome. Overall mean FF cytokine levels were higher in the MNC group for 29/40 cytokines, significantly so for leukaemia inhibitory factor and stromal cell-derived factor-1α. Furthermore, FF MNC cytokine correlations were significantly stronger than for COH data. Conclusions. These findings suggest that COH perturbs intrafollicular cytokine networks, in terms of both cytokine levels and their interrelationships. This may impact oocyte maturation/fertilization and embryo developmental competence.

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Section: Introductionsupporting

confidence: 55%

Impact of Exogenous Gonadotropin Stimulation on Circulatory and Follicular Fluid Cytokine Profiles

Baskind

Orsi

Sharma

2014

International Journal of Reproductive Medicine

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“…Moreover, not only for reducing the OHSS risk, in recent years the amount of FET cycles has dramatically increased due to the trend towards transferring fewer embryos after a fresh IVF cycle, and as a result of improved laboratory techniques [ 134 , 135 ] until to the emerging “freeze-all” policy as an alternative to fresh embryo transfer (ET) to improve IVF outcomes [ 106 ]. A recent prospective, observational, cohort study has suggested that the “freeze-all” policy is advantageous when compared with fresh ETs [ 136 ].…”

Section: Donor And/or Frozen-thawed Cyclesmentioning

confidence: 99%

Progesterone administration for luteal phase deficiency in human reproduction: an old or new issue?

2015

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Luteal phase deficiency (LPD) is described as a condition of insufficient progesterone exposure to maintain a regular secretory endometrium and allow for normal embryo implantation and growth. Recently, scientific focus is turning to understand the physiology of implantation, in particular the several molecular markers of endometrial competence, through the recent transcriptomic approaches and microarray technology. In spite of the wide availability of clinical and instrumental methods for assessing endometrial competence, reproducible and reliable diagnostic tests for LPD are currently lacking, so no type-IA evidence has been proposed by the main scientific societies for assessing endometrial competence in infertile couples. Nevertheless, LPD is a very common condition that may occur during a series of clinical conditions, and during controlled ovarian stimulation (COS) and hyperstimulation (COH) programs. In many cases, the correct approach to treat LPD is the identification and correction of any underlying condition while, in case of no underlying dysfunction, the treatment becomes empiric. To date, no direct data is available regarding the efficacy of luteal phase support for improving fertility in spontaneous cycles or in non-gonadotropin induced ovulatory cycles. On the contrary, in gonadotropin in vitro fertilization (IVF) and non-IVF cycles, LPD is always present and progesterone exerts a significant positive effect on reproductive outcomes. The scientific debate still remains open regarding progesterone administration protocols, specially on routes of administration, dose and timing and the potential association with other drugs, and further research is still needed.

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“…The accumulative success rate could be improved after one ovarian stimulation and retrieval cycle. Therefore, along with the refinement of laboratory techniques, the proportion of FET has increased [7] dramatically since the first baby after the frozen-thawed embryo transfer (FET) cycle was born in 1984 [8, 9]. …”

Section: Introductionmentioning

confidence: 99%

Which one has a better obstetric and perinatal outcome in singleton pregnancy, IVF/ICSI or FET?: a systematic review and meta-analysis

Zhao

Zhang

et al. 2016

Reprod Biol Endocrinol

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BackgroundThe present study aims to compare which one has a better obstetric and perinatal outcome in singleton pregnancy, frozen embryo transfer (FET) or. in vitro fertilization treatment/intracytoplasmic sperm injection (IVF/ICSI)?MethodsMEDLINE, Google Scholar and the Cochrane Library were searched for the obstetric and perinatal outcomes in singleton pregnancy after assisted reproductive technology (ART) from inception until July 2016. Clinical trials, which compared obstetric/perinatal outcomes in singleton pregnancy after FET and IVF/ICSI-ET, were included. The primary outcome was low birth weight, preterm birth, perinatal mortality, still birth, and cesarean section.ResultsThirteen cohort studies with 126,911 women were included, of which 12, 11, 6, 6, 5 studies were used to analyze low birth weight, preterm birth, perinatal mortality, still birth, and cesarean section, respectively. IVF/ICSI is associated with a high risk of preterm birth (OR = 1.14, 95 % CI: 1.02, 1.28) and low birth rate (OR = 1.48, 95 % CI: 1.37, 1.60). There was no significant difference in the risk of the still birth (OR = 1.01, 95 % CI: 0.76, 1.35) and perinatal mortality (OR = 1.11, 95 % CI: 0.85, 1.46) between FET and IVF/ICSI. Singleton pregnancy after FET was associated with higher cesarean section rate compared with IVF/ICSI (OR = 0.85, 95 % CI: 0.80, 0.91).ConclusionsSingleton pregnancy after FET seems to have a better perinatal outcome compared with that after IVF/ICSI. Further randomized controlled trials which adjust for a variety of meaningful confounders are needed in order to draw sound conclusions.Electronic supplementary materialThe online version of this article (doi:10.1186/s12958-016-0188-3) contains supplementary material, which is available to authorized users.

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Guidelines for the number of embryos to transfer following in vitro fertilization

Abstract: Society of Obstetricians and Gynaecologists of Canada. The quality of evidence reported in this document has been described using the Evaluation of Evidence criteria outlined in the Report of the Canadian Task Force on the Periodic Health Exam (Table 1).

Cited by 55 publications

References 145 publications

Impact of Exogenous Gonadotropin Stimulation on Circulatory and Follicular Fluid Cytokine Profiles

Impact of Exogenous Gonadotropin Stimulation on Circulatory and Follicular Fluid Cytokine Profiles

Progesterone administration for luteal phase deficiency in human reproduction: an old or new issue?

Which one has a better obstetric and perinatal outcome in singleton pregnancy, IVF/ICSI or FET?: a systematic review and meta-analysis

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