Guidelines for the management of thyroid cancer

Perros, Petros; Boelaert, Kristien; Colley, Steve; Evans, Carol; Evans, Rhordi M; Ba, Georgina Gerrard; Gilbert, Jackie; Harrison, Barney; Johnson, Sarah J.; Giles, T; Moss, Laura; Lewington, Val; Newbold, Kate; Taylor, Judith; Thakker, Rajesh V.; Watkinson, John; Williams, Graham R.

doi:10.1111/cen.12515

Cited by 1,051 publications

(1,257 citation statements)

References 693 publications

(869 reference statements)

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“…In the last few decades, several international guidelines on thyroid cancer diagnosis and management have been published [5][6][7][8]. Implicitly, these boards recommend early detection of DTC, specifically for advanced DTC which would require quick and radical initial treatment.…”

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confidence: 99%

“…An increase of the nodule's size was established when ultrasound examination showed enlargement of the nodule's dimension to be >50%. All FNA cytologies were classified according to the British Thyroid Association (BTA) system [7], and all tumors were classified according to the World Health Organization (WHO) classification [15] and staged by the most recently updated TNM staging system [4].…”

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confidence: 99%

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Early diagnosis by FNA cytology should not influence the outcome of differentiated thyroid cancer

et al. 2016

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confidence: 99%

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confidence: 99%

Early diagnosis by FNA cytology should not influence the outcome of differentiated thyroid cancer

et al. 2016

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“…The present study was conducted to answer this question. The criterion used for the definition of LN status (preoperative US and intraoperative inspection by the surgeon) agrees with current guidelines since there is no clear indication for elective LN dissection in patients with tumors ≤ 4 cm and without apparent extrathyroid invasion (1)(2)(3)(4)(5)(6)(7)23). …”

Section: Introductionmentioning

confidence: 61%

“…Although the impact on the prognosis is questionable, the presence of clinically apparent LNM [cN1, defined as LNM identified by preoperative physical examination or ultrasonography (US), or intraoperative inspection by the surgeon] excludes the patient from the group of low recurrence risk (1)(2)(3)(4)(5)(6) and frequently indicates a more aggressive initial approach (1)(2)(3)(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

Persistent and recurrent disease in patients with papillary thyroid carcinoma with clinically apparent (cN1), but not extensive, lymph node involvement and without other factors for poor prognosis

Furtado

Rosário

Calsolari

2015

Arch. Endocrinol. Metab.

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Objective: Lymph node metastases (LNM) are frequent in patients with papillary thyroid cancer (PTC). The risk of persistent disease (PD) and tumor recurrence (TR) is increased when factors for poor prognosis other than LNM exist, when LNM are numerous, large, detected by preoperative ultrasonography (US), or exhibit extranodal extension. This study evaluated the risk of PD and TR in patients with LNM not exhibiting these characteristics. Subjects and methods: Eighty-six patients with 5 or fewer LNM detected during intraoperative inspection, but not by preoperative US, who had no other factors for poor prognosis [tumors > 4 cm, extensive extrathyroid invasion, vascular invasion, aggressive histological subtype, distant metastases, incomplete tumor resection], were studied. All patients underwent total thyroidectomy followed by radioiodine ablation. PD was defined as metastases on initial post-therapy whole-body scans (RxWBS) or detected by imaging methods up to 12 months after ablation. TR was defined as structural disease diagnosed more than one year after ablation in patients without PD. Results: PD was diagnosed in 3/86 patients (3.5%). TR was observed in 2/83 patients (2.5%) after 62 months of follow-up. There was no case of death due to the disease. A correlation was observed between pre-ablation Tg and PD or TR [1/48 (2%) with Tg ≤ 2 ng/mL versus 2/22 (9%) with Tg > 2 ≤ 10 ng/mL versus 2/7 (28.5%) with Tg ≥ 10 ng/ml)]. It is noteworthy that 38 patients had up to 3 positive LN and pre-ablation Tg ≤ 2 ng/ml, and none of them had PD or TR. Conclusions: The frequency of PD and TR was low in patients with PTC with 5 or fewer LNM and without other factors for poor prognosis. Low postoperative stimulated Tg was predictive of the absence of PD and TR in these patients. Arch Endocrinol Metab. 2015;59(4):285-91

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“…In a North American cohort, the median age of thyroidectomy for MEN2B patients with medullary thyroid carcinoma was 13.5 years (range 5-25.5) [95]. The British Thyroid Association advises thyroid surgery as early as possible and preferably before the age of one year [96].…”

Section: Clinical Featuresmentioning

confidence: 99%

An Overview of Autosomal Dominant Tumour Syndromes with Prominent Features in the Oral and Maxillofacial Region

Kennedy

Thavaraj

Díaz‐Cano

2017

Head and Neck Pathol

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Guidelines for the management of thyroid cancer

Cited by 1,051 publications

References 693 publications

Early diagnosis by FNA cytology should not influence the outcome of differentiated thyroid cancer

Early diagnosis by FNA cytology should not influence the outcome of differentiated thyroid cancer

Persistent and recurrent disease in patients with papillary thyroid carcinoma with clinically apparent (cN1), but not extensive, lymph node involvement and without other factors for poor prognosis

An Overview of Autosomal Dominant Tumour Syndromes with Prominent Features in the Oral and Maxillofacial Region

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