Guidelines for the management of herpes simplex virus in pregnancy

doi:10.1016/j.ijgo.2008.10.028

Cited by 18 publications

(5 citation statements)

References 33 publications

(37 reference statements)

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“…The perinatal mortality is 50%.The risk of neonatal infection varies from 30% to 50% for HSV infections that onset in late pregnancy (last trimester), whereas early pregnancy infection carries a risk of about 1%. 17 In our study Herpes simplex IgG was seen in 0.9% of the cases with only one case of recent infection.…”

Section: Herpes Simplex Virussupporting

confidence: 43%

Epidemiological and serological profiles of TORCH infection in pregnancy

Pradhan

2015

J Pathol Nep

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Background: Maternal infections caused by TORCH [Toxoplasma gondii, Rubella virus, Cytomegalovirus (CMV), Herpes simplex virus (HSV)] are the major causes of bad obstetric history. The aim of this study was to evaluate the prevalence of TORCH infections in pregnancyMaterials and Methods:The study included 109 pregnant women with unfavorable previous pregnancy. Serological evaluation for TORCH infections was carried out by IgM Enzyme Linked Immunosorbant Assay method. Data was analyzed using SPSS 17.0 whenever necessary.Results: The IgM/ IgG sero-positivity to T. gondii, Rubella, CMV and HSV-2 was 26.6/9.2 %, 9.2/78.9%, 17.4/58.7%, and 4.6/35.8 % respectively. There was an increased percentage of CMV infection. There was increased number of recent Toxoplasma infection in comparison to other studies conducted.Conclusion: A previous history of pregnancy wastage and the serological reaction for TORCH infections during current pregnancy must be considered while managing BOH cases so as to reduce the adverse fetal outcome.Journal of Pathology of Nepal (2015) Vol. 5, 705-708

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Section: Herpes Simplex Virussupporting

confidence: 43%

Epidemiological and serological profiles of TORCH infection in pregnancy

Pradhan

2015

J Pathol Nep

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“…The mother is the most common source of infection for the first two routes of viral transmission. Congenital infection is very rare due to the acquisition of the virus in utero; it comes to the neonatal HSV infection when the appearances of the lesions are more than 48 hours after birth [24, 25]. …”

Section: Congenital and Neonatal Infectionmentioning

confidence: 99%

Herpes Simplex Virus Infection in Pregnancy

Straface

Selmin

Zanardo

et al. 2012

Infectious Diseases in Obstetrics and Gynecology

122

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Infection with herpes simplex is one of the most common sexually transmitted infections. Because the infection is common in women of reproductive age it can be contracted and transmitted to the fetus during pregnancy and the newborn. Herpes simplex virus is an important cause of neonatal infection, which can lead to death or long-term disabilities. Rarely in the uterus, it occurs frequently during the transmission delivery. The greatest risk of transmission to the fetus and the newborn occurs in case of an initial maternal infection contracted in the second half of pregnancy. The risk of transmission of maternal-fetal-neonatal herpes simplex can be decreased by performing a treatment with antiviral drugs or resorting to a caesarean section in some specific cases. The purpose of this paper is to provide recommendations on management of herpes simplex infections in pregnancy and strategies to prevent transmission from mother to fetus.

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“…Similarly, it is pertinent to identify asymptomatic recurrent HSV-2 infection in pregnancy as such women are at risk of viral shedding during delivery. [11121314151617] Of the asymptomatic HSV-2-seropositive women identified in our study, majority (56/90 [62.2%]) presented in their 2 nd trimester while 18.9% (17/90) in their 3 rd trimester.…”

Section: Discussionmentioning

confidence: 82%

“…Recent findings reveal that primary HSV-2 infection of the mother is the most important factor for the transmission of genital herpes from mother to fetus/newborn. [111213141516] Besides high concentrations of activated CD4-positive T cells, which are target cells for HIV in the genital area, genital ulceration and viral shedding occur most frequently in the 1 st year of HSV-2 infection. [3233] Therefore, by inference, a pregnant woman who acquires primary genital herpes in the latter half of pregnancy rather than before pregnancy is at greater risk of transmitting these viruses to her newborn.…”

Section: Discussionmentioning

confidence: 99%

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Co-infection of herpes simplex virus type 2 and HIV infections among pregnant women in Ibadan, Nigeria

Anaedobe

Ajani

2019

J Global Infect Dis

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Introduction: Genital infection with herpes simplex virus type 2 (HSV-2) facilitates the acquisition of HIV, both mutually reinforcing infection. Lifelong latent HSV-2 infection raises concerns among women of reproductive age, considering the risk of neonatal transmission. In Nigeria, screening for HSV-2 and co-infection with HIV in antenatal clinics is not routine. This study was undertaken to determine the seroprevalence and co-infection of HSV-2 and HIV among pregnant women. Methods: This was a cross-sectional study conducted at the antenatal clinic of the University College Hospital, Ibadan, between March and August 2013. A total of 270 consenting pregnant women were enrolled. The study involved collecting socio-demographic data and laboratory determination of HSV-2 immunoglobulin G (IgG) and HIV seroprevalence using type-specific third-generation enzyme-linked immunosorbent assay (DIAPRO Diagnostic Bioprobes, Milan, Italy) and Uni-Gold Recombigen/ALERE determine, respectively. Data analyses were done using SPSS version 20 (SPSS Inc., IL, USA). Results: The seroprevalence for HSV-2 type-specific IgG was 33.3% (90/270), and HIV antibodies were identified in 19.63% (53/270) of the women. The HIV co-infection was 38.8% (35/90) among HSV-2-positive women and 10% (18/180) among HSV-2-negative women. Majority of the HSV-2 positive women (62.2%, 56/90) presented in their 2 nd trimester while 18.9% (17/90) in their 3 rd trimester. Conclusion: The seroprevalence of HSV-2 in this pregnant population is lower than what is observed in some other Sub-Saharan African countries; however, HSV-2/HIV co-infection is high. The HSV-2-seronegative women are still susceptible to primary HSV-2 infection in pregnancy with increased risk for HIV co-infection and neonatal transmission.

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Guidelines for the management of herpes simplex virus in pregnancy

Abstract: Recommendations were made according to the guidelines developed by the Canadian Task Force on Preventive Health Care.

Cited by 18 publications

References 33 publications

Epidemiological and serological profiles of TORCH infection in pregnancy

Epidemiological and serological profiles of TORCH infection in pregnancy

Herpes Simplex Virus Infection in Pregnancy

Co-infection of herpes simplex virus type 2 and HIV infections among pregnant women in Ibadan, Nigeria

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