Guidelines for the investigation of invasive fungal infections in haematological malignancy and solid organ transplantation

Denning, David W.; Evans, E. G. V.; Kibbler, C; Richardson, Malcolm; Roberts, M.; Rogers, Thomas R.; Warnock, David W.; Warren, Richard M.

doi:10.1007/bf02471906

Cited by 145 publications

(86 citation statements)

References 88 publications

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“…Additionally, an increasing frequency of infections caused by fungi and an increased mortality due to them has been reported [18]. However, only two fungal infections were detected in our study.…”

Section: Discussioncontrasting

confidence: 58%

Evaluation of febrile neutropenic attacks in a tertiary care medical center in Turkey

Saçar

Hacioglu

Keskïn

et al. 2008

J Infect Dev Ctries

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Background: Infectious complications in febrile neutropenic patients are still major causes of morbidity and mortality despite significant advances in diagnostic techniques and antimicrobial therapy. In this study, we describe the characteristics of patients with hematological malignancies who were evaluated for suspected infection. This study was also conducted to assess the isolation rate of bacterial and fungal causative agents in febrile neutropenic attacks. Method: The study was conducted at Pamukkale University Hospital, Turkey. In order to identify the characteristics of patients with hematological malignancies in the presence/suspicion of any accompanying infectious disease, patients' charts with hematological malignancies were reviewed for signs/symptoms of any infection between October 1, 2001, and May 31, 2005, retrospectively. Results: Overall, 90 infectious episodes occurred in 59 patients. The most common underlying diseases were acute myelogenous leukemia (61.0%) and acute lymphocytic leukemia (15.3%). The absolute neutrophil count was lower than 100/mm³ in 33 (36.7%) episodes. Microbiologically and clinically documented infections and fever of unknown origin were observed in 35.6%, 28.9%, and 35.6% of the participants, respectively. Bloodstream infections and pneumonia were detected in 21.1% and 18.9% of episodes, respectively. Gram negative organisms were most common (58.4%), followed by gram positive cocci. A combination of third generation cephalosporin and an aminoglycoside were used in 44.4% of episodes initially. Fever resolved in 24.4% of episodes using the initial therapy. The mortality rate was 15.6%. Conclusion: These results showed that infections with gram-negative bacteria continue to predominate in febrile neutopenic episodes in our center.

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Section: Discussioncontrasting

confidence: 58%

Evaluation of febrile neutropenic attacks in a tertiary care medical center in Turkey

Saçar

Hacioglu

Keskïn

et al. 2008

J Infect Dev Ctries

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“…This result is similar to other studies. Additionally, an increasing frequency of infections caused by fungi and an increased mortality due to them has been reported [13]. Fifty-six out of 226 positive cultures were candida spp.…”

Section: Discussionmentioning

confidence: 99%

Bacterial Spectrum and Antimicrobial Susceptibility Pattern of Bloodstream Infections in Children with Febrile Neutropenia: Experience of Single Center in Southeast of Turkey

et al. 2011

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Empirical antimicrobial therapy is usually started in febrile neutropenic patients without having culture results. The aim of this study was to help determine the policies of empirical antibiotic usage in febrile neutropenic children by detecting the antimicrobial susceptibility profile in this group of patients. In this study 811 blood cultures taken from neutropenic children hospitalized at the Department of Oncology of Gaziantep Children Hospital November 2007 and February 2010 were retrospectively evaluated. Blood cultures were routinely collected in aerobic and anaerobic media and incubated using the BACTEC system. Identification and antimicrobial susceptibility testing of the isolates to antimicrobial agents was performed using the Vitek2 Ò system according to the recommendations of the Clinical and Laboratory Standards Institute. Of 811 isolates analyzed, 128 (56.4%) were gram positive cocci, 43 (18.9%) were gram negative bacilli and fungi accounted for 56 (24.7%). The main isolated Gram-positive bacteria from blood were coagulase-negative staphylococcus (56.7%), followed by methicillin-resistant Staphylococcus aureus (14.1%). S. aureus and Streptococcus spp. were all susceptible to linezolid, vancomycin and teicoplanin. S aureus was still susceptible to few other antimicrobial agents such as tetracycline (82.4%), chloramphenicol (55.6%). Seven E. faecium, 7 E. fecalis and 1 E. hirae was isolated from blood cultures. Vancomycin resistance was detected in 6 out of 15 (40%) Enterococcus spp. isolates. Among gram-negative bacteria E. coli (30.2%) was followed by Klebsiella pneumoniae (20.9%) and Proteus spp. (18.6%). Imipenem (89.2%), meropenem (86.6%), chloramphenicol (88.9%), amicasin (82.4%) and fosfomycin (81.3%) showed highest susceptibility in vitro activity against all Gram-negative isolates. To know the antimicrobial susceptibility profile of the pathogens frequently isolated from febrile neutropenic children and to consider this profile before starting an empirical antibiotic therapy would help the clinics which have any role in the treatment of these patients to determine the empirical antibiotic usage policies.

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“…22 Blood samples were incubated in a BACTEC 9240 system (Becton Dickinson, Le Pont de Claix, France).…”

Section: Microbiological Investigationsmentioning

confidence: 99%

A prospective analysis of the genotypic diversity and dynamics of the Candida albicans colonizing flora in neutropenic patients with de novo acute leukemia

Dalle¹,

Lafon²,

L’Ollivier³

et al. 2008

Haematologica

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Guidelines for the investigation of invasive fungal infections in haematological malignancy and solid organ transplantation

Cited by 145 publications

References 88 publications

Evaluation of febrile neutropenic attacks in a tertiary care medical center in Turkey

Evaluation of febrile neutropenic attacks in a tertiary care medical center in Turkey

Bacterial Spectrum and Antimicrobial Susceptibility Pattern of Bloodstream Infections in Children with Febrile Neutropenia: Experience of Single Center in Southeast of Turkey

A prospective analysis of the genotypic diversity and dynamics of the Candida albicans colonizing flora in neutropenic patients with de novo acute leukemia

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