Guidelines for the ethical use of animals in applied ethology studies

Sherwin, CM; Christiansen, Stine B.; Duncan, Ian; Erhard, Hans W.; Lay, D. C.; Mench, Joy A.; O'Connor, C. E.; Petherick, J. Carol

doi:10.1016/s0168-1591(02)00288-5

Cited by 212 publications

(127 citation statements)

References 21 publications

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“…Due to the proliferation of oxytocin receptors, this responsiveness may not be saturated by endogenous oxytocin and therefore exogenous administration of this hormone was able to favor its uterotonic effects. Uterine hyperstimulation may decrease uterine blood supply that may subsequently result in fetal distress (Sherwin et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

“…The study was approved at the Department of Animal Production & Agriculture, Universidad Autónoma Metropolitana-Xochimilco, México DF, Mexico, and was performed in accordance with the guidelines of the ethical use of animals in applied ethology studies described elsewhere (Sherwin et al, 2003). It was assumed that procedures added mild pain, suffering and distress to that expected during standard attention in the labor process.…”

Section: Methodsmentioning

confidence: 99%

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Influence of time at which oxytocin is administered during labor on uterine activity and perinatal death in pigs

et al. 2007

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Oxytocin is extensively used to induce or augment uterine contractions, especially to facilitate the third stage of labor in humans. Administration of oxytocin to parturient sows reduces duration of labor whereas mortality of the offspring may remain unchanged. This study aimed to evaluate whether time of administration of oxytocin during parturition may alter the uterine response and fetal outcomes. Two hundred parturient sows were randomly assigned to intramuscularly receive either saline solution (control group) or oxytocin 0.083 IU/kg immediately after the delivery of the 1 st , 4 th or 8 th piglet (groups O-1, O-4 and O-8, respectively). Uterine effects and fetal outcomes were registered in all groups. The duration of labor was 20-40 min shorter (P < 0.0001) and time interval between babies was reduced by 3-5 min (P < 0.0001) in the three groups receiving oxytocin. The duration and intensity of contractions, meconium-stained piglets and intrapartum deaths decreased as time at which oxytocin administered during labor was increased. In group O-8, we observed approximately 70% less meconium-stained piglets and intrapartum deaths than in the control group. In conclusion, oxytocin administered at early phases of parturition to sows may increase duration and intensity of uterine contractions as well as adverse fetal outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Influence of time at which oxytocin is administered during labor on uterine activity and perinatal death in pigs

et al. 2007

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“…This work was carried out according to the local ethic protocol and according to the guidelines for the ethical use of animals in applied ethological studies (Sherwin et al, 2003).…”

Section: Ethicsmentioning

confidence: 99%

Differential effects of undernutrition during pregnancy on the behaviour of does and their kids at parturition and on the establishment of mutual recognition

Terrazas

Robledo

Serafín

et al. 2009

Animal

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We investigated whether undernutrition during the second half of pregnancy impaired the behaviour of does and their kids at parturition and early mutual recognition. Twenty-two control and 22 underfed mixed-breed, multiparous dairy goats were used, together with their respective kids (control,n= 31: nine singles, 16 twins and six triplets; underfed,n= 32: 11 singles, 18 twins and three triplets). Undernutrition involved limiting protein and energy intake at 70% of the nutritional requirements for maintenance and foetal growth from day 70 of pregnancy until birth. The behaviour of mothers and their two first-born kids was observed for 90 min from the birth of each kid. Maternal olfactory recognition of the kid was assessed at 4 hpost partumby testing selective nursing behaviour. Non-olfactory recognition was assessed at 8 h in a two-choice test excluding olfactory cues. In kids, preference for the mother was assessed in a two-choice test at either 12 or 24 hpost partum. Bodyweight of does and kids were lower in the underfed group up to 2 weekspost partum. At parturition, licking, maternal bleating frequency and latency to nursing did not differ between nutritional groups. Control kids were faster than underfed kids to stand, search for and reach the udder, but underfed kids bleated more and tended to spend more time at the udder. Both control and underfed does accepted their own kid and rejected the alien in the selectivity test at 4 h. In contrast, at 8 hpost partum, only control goats showed a significant preference for their own kid in the non-olfactory recognition test. Both control and underfed kids showed a preference for their own mother at 12 and 24 h and undernutrition during pregnancy had little influence on the performance of kids. However, 12 h-old underfed kids tended to be less active than control kids and visited their own mothers less than control kids. There were no significant correlations between the behaviour of the mother or of the kid at parturition and their performance in the discrimination tests. Overall, undernutrition in the second half of pregnancy appears to be more detrimental for the behaviour of the mother than for the kid. Furthermore, it has more impact on the establishment of maternal non-olfactory recognition than on maternal care at parturition or the establishment of maternal selectivity.

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“…The experimental protocols were approved by the Institutional Review Committee for the use of animal subject (CEPA Nº 0602/05) of the Federal University of Paraiba, Brazil. All experiments were carried out with strict adherence to ethical guidelines (Sherwin et al, 2003).…”

Section: Animalsmentioning

confidence: 99%

Cissampelos sympodialis Eichl. (Menispermaceae) inhibits anaphylactic shock reaction in murine allergic model

Bezerra-Santos¹,

Pecanha²,

Piuvezam³

2005

Rev. bras. farmacogn.

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The murine model of OVA-induced immediate allergic reaction was used to evaluate the effectiveness of intraperitoneal sub-acute treatment with the leaf hydroalcoholic extract of Cissampelos sympodialis (AFL) in the anaphylactic shock reaction, IgE production and the background proliferative response. BALB/c mice treated with AFL ranging from 200 to 400 mg/kg/day for 5 days before and during OVA-sensitization strongly reduced the animal death and promoted reduction in total and OVA-specifi c serum IgE level. Spleen cells from AFL-treated sensitized animals showed a decreased proliferative background response when compared with non-sensitized animals. These results demonstrated that sub-acute intraperitoneal treatment with Cissampelos sympodialis extract has an anti-allergic effect.

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Guidelines for the ethical use of animals in applied ethology studies

Cited by 212 publications

References 21 publications

Influence of time at which oxytocin is administered during labor on uterine activity and perinatal death in pigs

Influence of time at which oxytocin is administered during labor on uterine activity and perinatal death in pigs

Differential effects of undernutrition during pregnancy on the behaviour of does and their kids at parturition and on the establishment of mutual recognition

Cissampelos sympodialis Eichl. (Menispermaceae) inhibits anaphylactic shock reaction in murine allergic model

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