Guidelines for the diagnosis of dementia and Alzheimer's disease

Sorbi, Sandro; Alberoni, Margherita; Alfieri, Pasquale; Amici, Serena; Antana, Daniele; Appollonio, Ildebrando; Avanzi, Stefano; Bartoli, Antonella; Bergamasco, B.; Bracco, Laura; Bruni, Amalia C.; Bugiani, Orso; Caffarra, Paolo; Caltagirone, Carlo; Carolei, Antonio; Rosa, Anna De; Ciannella, L; Citterio, A.; Daniele, Antonio; D'Achille, Graziella; Curatolo, Giuseppe Del; Dell’Agnello, Grazia; Durante, Daniele; Farina, Elisabetta; Ferrero, P.; Forleo, Paolo; Gainotti, Guido; Gabriele, Paolo; Galante, Emanuela; Gallai, Virgilio; Gallassi, Roberto; Gasparini, M.; Ghetti, Bernardino; Giaccone, Giorgio; Girotti, F.; Grimaldi, Luigi M. E.; Grioli, S; Guarnieri, Biancamaria; Grottoli, Stefano; Iemolo, Francesco; Latorraca, Stefania; Pira, Francesco Le; Lenzi, Gian Luigi; Lorusso, Sebastiano; Mariani, Claudio; Marcon, Gabriella; Mascia, V.; Mearelli, S.; Morante, María Carmen Fernández; Morbin, Michela; Musicco, Massimo; Nardelli, E.; Nichelli, Paolo Frigio; Padovani, Alessandro; Paganini, Marco; Pantieri, Roberta; Parisen, P.; Parnetti, Lucilla; Passerella, Bruno; Pettenati, Carla; Piacentini, Silvia; Piccoli, Federico; Piccolini, Carlo; Pizzolato, Gilberto; Provinciali, Leandro; Pugliese, Nicola Riccardo; Redi, Francesco; Ruggieri, R. M.; Ruggiero, Umberto; Saetta, Marco; Schoenuber, Rudolf; Silveri, Maria Caterina; Sorrentino, Giuseppe; Sucapane, Patrizia; Stracciari, Andrea; Tabaton, Massimo; Tagliavini, Fabrizio; Toso, V.; Valluzzi, Francesco

doi:10.1007/s100720070075

Cited by 37 publications

(3 citation statements)

References 20 publications

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“…Patients (19.7% autopsy proven) were clinically evaluated according to published guidelines, and the AD diagnosis fulfilled the Diagnostic and Statistical Manual of Mental Disorders criteria (DSM-IV) [10, 11]. Presence of a family history of dementia was considered an exclusion criterion.…”

Section: Methodsmentioning

confidence: 99%

Association Study of Genetic Variants in CDKN2A/CDKN2B Genes/Loci with Late‐Onset Alzheimer′s Disease

Tedde

Piaceri

Bagnoli

et al. 2011

International Journal of Alzheimer's Disease

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Alzheimer's disease (AD) is the most common form of dementia clinically characterized by progressive impairment of memory and other cognitive functions. Many genetic researches in AD identified one common genetic variant (ε4) in Apolipoprotein E (APOE) gene as a risk factor for the disease. Two independent genome-wide studies demonstrated a new locus on chromosome 9p21.3 implicated in Late-Onset Alzheimer's Disease (LOAD) susceptibility in Caucasians. In the present study, we investigated the role of three SNP's in the CDKN2A gene (rs15515, rs3731246, and rs3731211) and one in the CDKN2B gene (rs598664) located in 9p21.3 using an association case-control study carried out in a group of Caucasian subjects including 238 LOAD cases and 250 controls. The role of CDKN2A and CDKN2B genetic variants in AD is not confirmed in our LOAD patients, and further studies are needed to elucidate the role of these genes in the susceptibility of AD.

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Section: Methodsmentioning

confidence: 99%

Association Study of Genetic Variants in CDKN2A/CDKN2B Genes/Loci with Late‐Onset Alzheimer′s Disease

Tedde

Piaceri

Bagnoli

et al. 2011

International Journal of Alzheimer's Disease

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“…The AD patients were clinically evaluated according to the published guidelines and the AD diagnosis fulfilled the Diagnostic and Statistical Manual of Mental Disorders criteria (DSM-IV) [23, 24]. According to disease age at onset and absence of a family history of dementia all the AD subjects were assumed to be sporadic late-onset (>65 years) cases.…”

Section: Methodsmentioning

confidence: 99%

A Pilot Study Evaluating the Contribution ofSLC19A1(RFC-1) 80G>A Polymorphism to Alzheimer’s Disease in Italian Caucasians

Coppedè

Tannorella

Tognoni³

et al. 2014

BioMed Research International

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Alzheimer's disease (AD) is the most common neurodegenerative disorder and the primary form of dementia in the elderly. Polymorphisms of genes involved in folate metabolism have been frequently suggested as risk factors for sporadic AD. A common c.80G>A polymorphism (rs1051266) in the gene coding for the reduced folate carrier (SLC19A1 gene, commonly known as RFC-1 gene) was investigated as AD risk factor in Asian populations, yielding conflicting results. We screened a Caucasian population of Italian origin composed of 192 sporadic AD patients and 186 healthy matched controls, for the presence of the RFC-1 c.80G>A polymorphism, and searched for correlation with circulating levels of folate, homocysteine, and vitamin B12. No difference in the distribution of allele and genotype frequencies was observed between AD patients and controls. No correlation was observed among the genotypes generated by the RFC-1 c.80G>A polymorphism and circulating levels of folate, homocysteine, and vitamin B12 either in the whole cohort of subjects or after stratification into clinical subtypes. Present results do not support a role for the RFC-1 c.80G>A polymorphism as independent risk factor for sporadic AD in Italian Caucasians.

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“…In view of this well-documented and widely recognized problem of inadequate recognition of dementia, national and international advisory- and policy-making groups have evaluated the possibility of earlier diagnosis facilitated by screening for dementia or mild cognitive impairment [31–37]. However, the U.S. Preventive Services Task Force concluded in its 2014 statement that evidence was insufficient to recommend routine screening for cognitive impairment in community-dwelling adults in the general primary care population who are older than 65 years [38].…”

Section: Introductionmentioning

confidence: 99%

Validity of screening instruments for the detection of dementia and mild cognitive impairment in hospital inpatients: A systematic review of diagnostic accuracy studies

et al. 2019

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Introduction As the population ages, Alzheimer's disease and other subtypes of dementia are becoming increasingly prevalent. However, in recent years, diagnosis has often been delayed or not made at all. Thus, improving the rate of diagnosis has become an integral part of national dementia strategies. Although screening for dementia remains controversial, the case is strong for screening for dementia and other forms of cognitive impairment in hospital inpatients. For this reason, the objective of this systematic review was to provide clinicians, who wish to implement screening, an up-to-date choice of cognitive tests with the most extensive evidence base for the use in elective hospital inpatients. Methods For this systematic review, PubMed, PsycINFO and Cochrane Library were searched by using a multi-concept search strategy. The databases were accessed on April 10, 2019. All cross-sectional studies that utilized brief, multi-domain cognitive tests as index test and a reference standard diagnosis of dementia or mild cognitive impairment as comparator were included. Only studies conducted in the hospital setting, sampling from unselected, elective inpatients older than 64 were considered. Results Six studies met the inclusion criteria, with a total of 2112 participants. Diagnostic accuracy data for the Six-Item Cognitive Impairment Test, Cognitive Performance Scale, Clock-Drawing Test, Mini-Mental Status Examination, and Time & Change test were extracted and descriptively analyzed. Clinical and methodological heterogeneity between the studies precluded performing a meta-analysis. Discussion This review found only a small number of instruments and was not able to recommend a single best instrument for use in a hospital setting. Although it was not possible to estimate the pooled operating characteristics, the included description of instrument characteristics, the descriptive analysis of performance measures, and the critical evaluation of the reporting studies may contribute to clinician's choice of the screening instrument that fits best their purpose.

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Guidelines for the diagnosis of dementia and Alzheimer's disease

Cited by 37 publications

References 20 publications

Association Study of Genetic Variants in CDKN2A/CDKN2B Genes/Loci with Late‐Onset Alzheimer′s Disease

Association Study of Genetic Variants in CDKN2A/CDKN2B Genes/Loci with Late‐Onset Alzheimer′s Disease

A Pilot Study Evaluating the Contribution ofSLC19A1(RFC-1) 80G>A Polymorphism to Alzheimer’s Disease in Italian Caucasians

Validity of screening instruments for the detection of dementia and mild cognitive impairment in hospital inpatients: A systematic review of diagnostic accuracy studies

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