Guidelines for the diagnosis and treatment of osteoarthritis in China (2019 edition)

Zhang, Zhiyi; Huang, Cibo; Jiang, Quan; Zheng, Yi; Liu, Yi; Liu, Shengyun; Chen, Yingjuan; Mei, Yifang; Ding, Changhai; Chen, Min; Gu, Xin; Xing, Dan; Gao, Min; He, Lan; Ye, Zhizhong; Wu, Lijun; Xu, Jianhua; Yang, Pinting; Zhang, Xuewu; Zhang, Yue; Chen, Jinwei; Lin, Jin; Zhao, Lingli; Li, Mengtao; Yang, Wanling; Zhou, Yixin; Jiang, Qing; Chu, Cong‐Qiu; Chen, Yaolong; Wei-ya, Zhang; Tsai, Wei–Chung; Lei, Guanghua; He, Dongyi; Liu, Wei; Fang, Yongfei; Wu, Darong; Lin, Jianhao; Wei, Cheng-Chung; Lin, Hsiao-Yi; Zeng, Xiaofeng

doi:10.21037/atm-20-4665

Cited by 86 publications

(86 citation statements)

References 109 publications

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“…Study control: For patients diagnosed with knee osteoarthritis, the diagnostic criteria are based on the KOA diagnostic criteria established by American College of Rheumatology (ACR) or Chinese Orthopaedic Association (COA), [ 14 ] and sex, race, age, and occupation are not restricted.…”

Section: Methodsmentioning

confidence: 99%

Comparing the efficacy of non-invasive physical therapy in improving pain and joint function of knee osteoarthritis

Cai¹,

Xiao³

et al. 2021

Medicine

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Background: The incidence of knee osteoarthritis is increasing year by year, which seriously affects people's quality of life, especially the elderly, and has become a major public health problem. A lot of evidence shows that physical therapy has advantages in the treatment of knee joints, but there are a number of physical therapy schemes, and the efficacy of each scheme is different. This study will evaluate the clinical efficacy of different physical therapy regimens in the treatment of knee osteoarthritis (KOA) by means of network meta-analysis. Methods: According to the search strategy, we will retrieve the randomized controlled studies of non-invasive physical therapy in the treatment of knee osteoarthritis from CNKI, Wanfang, VIP, China Biomedical medicine, PubMed, Embase, Web of Science, and The Cochrane Library databases. The retrieval time was from the establishment of the database to March 2021. We will assess the quality of the studies using the Cochrane Risk Bias Assessment Tool and assess the strength of the evidence using the GRADE methodology. All data analyses will be performed by RevMan5.3, GEMTC 0.14.3, and Stata 14.0. Results: This study will evaluate the efficacy of different physical therapy in the treatment of knee osteoarthritis by evaluating the total response rate, pain relief degree, joint function score, quality of life score, adverse reactions, etc. Conclusions: This study will provide a reliable evidence-based basis for the selection of better physical therapy for the treatment of knee osteoarthritis. OSF Registration number: DOI 10.17605/OSF.IO/VX98B

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Section: Methodsmentioning

confidence: 99%

Comparing the efficacy of non-invasive physical therapy in improving pain and joint function of knee osteoarthritis

Cai¹,

Xiao³

et al. 2021

Medicine

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“…Остеоартрит (ОА) -прогрессирующее заболевание суставов, вызывающее хроническую боль, нарушение функции, снижение трудовой и социальной активности пациентов [1,2]. Эта болезнь относится к числу глобальных вызовов, стоящих перед современной медициной и обществом: учитывая общее старение популяции, эпидемиологи ожидают увеличение числа больных ОА к 2030 г. до 400 млн человек [3]. По данным международного исследования социальных последствий болезней, ОА на 2017 г. занимал 11-е место среди всех нозологических форм, характеризующихся стойкой утратой трудоспособности [4].…”

Section: Introductionunclassified

“…Российские ученые, базируясь на данных национального эпидемиологического исследования, оценивают частоту ОА в нашей стране на уровне 13% [7]. Частота ОА нарастает с возрастом: так, у лиц старше 40 лет она составляет 10-17%, 60 лет и старше -50%, 75 лет и старше -до 80% [3].…”

Section: Introductionunclassified

“…Хроническое низкоинтенсивное воспаление, боль, депрессия, тревожность и ограничение физической активности, связанные с ОА, способствуют прогрессированию коморбидной патологии, в первую очередь сердечно-сосудистой системы [1][2][3]. Результаты популяционных исследований демонстрируют, что у пациентов с ОА достоверно чаще (на 40-50%) возникают угрожающие жизни кардиоваскулярные осложнения, такие как инфаркт миокарда и ишемический инсульт, в сравнении с общей популяцией [8][9][10].…”

Section: Introductionunclassified

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Efficacy of combined use of glycosaminoglycan peptide complex for intramuscular administration and oral diacerein in osteoarthritis: evaluation according to an observational multicenter clinical trial

Каратеев

Алексеева

Pogozheva

et al. 2021

Terapevticheskii arkhiv

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Background. The combined use of intramuscular injection glycosaminoglycan peptide complex (GPC) and oral diacerein can increase the effectiveness of treatment of osteoarthritis (OA). Aim. Compare the effectiveness of combination GPC + diacerein and GPC monotherapy in the treatment of OA in clinical practice. Materials and methods. A retrospective evaluation of the results of a 12-week multicenter observational non-interventional study of the effectiveness of GPC (Rumalon, a course of intramuscular injections 3 times a week, №25) in patients with moderate/severe OA (n=2955) requiring regular administration of nonsteroidal anti-inflammatory drugs (NSAIDs). The analysis identified a group of patients (n=414) who received GPC in combination with diacerein 100 mg/day (Diaflex Rompharm). The therapeutic effect was compared in the groups of GPC monotherapy (n=2541) and the combination of GPC with diacerein. These groups did not differ in average age (61.411.8 and 61.911.3 years), both were dominated by women (76.3 and 70.3%), there was approximately equal intensity of pain during movement and impaired joint function: 6.11.8/6.01.6 and 4.92.1/5.11.8 (according to the numerical rating scale 010). The dynamics of pain intensity, the need for NSAIDs, and the frequency of adverse events (AE) were compared 12 weeks after the start of treatment. Results and discussion. In the majority of patients with OA both on the background of GPC monotherapy and combined use of GPC and diacerein, there was a significant improvement. The number of patients with pain reduction 50% was 54.3 and 62.8% (p0.001), NSAID administration was completely stopped in 66.7 and 77.5% (p0.001), respectively. The effectiveness of the combination of GPC and diacerein was significantly higher than that of GPC monotherapy in OA of the knee joint, hip joint, and generalized OA. AE from the gastrointestinal tract was observed in 7.8 and 8.9%, arterial hypertension in 6.3 and 4.6%, allergic reactions in 0.3 and 0.5% of patients (not significant). Conclusion. The application of the code of civil procedure is an effective treatment for OA. The combination of GPC and diacerein provides a more significant improvement than GPC monotherapy. GPC and diacerein (including in combination) are well tolerated and rarely cause AE.

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“…Osteoarthritis (OA) is a common chronic disease characterized by a series of degenerative changes of the joint including articular cartilage degradation, reduction of chondrocyte count, and periarticular osteophyte formation (1). Its exact etiology and pathogenesis remain unclear.…”

Section: Introductionmentioning

confidence: 99%

Molecular mechanism of Wutou Decoction in the treatment of osteoarthritis: a bioinformatics and molecular docking study

Yan

Luo

et al. 2021

Ann Palliat Med

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Background: Osteoarthritis (OA) is a chronic joint disease characterized by cartilage destruction and periarticular osteophyte formation. One therapeutic option for this condition, the Wutou Decoction (WTD)Chinese medicine formula, is satisfactory in its efficacy. Here, we used bioinformatic and molecular docking techniques to investigate the mechanism of action of WTD in the treatment of OA.Methods: The active compounds (and their target proteins) of 5 Chinese herbs in WTD were obtained by searching the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform.The action targets of WTD for OA were obtained by searching the Therapeutic Target Database and by mining the microarray data in the Gene Expression Omnibus. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed to identify key targets for OA treatment with the help of Database for Annotation, Visualization, and Integrated Discovery. Based on the Cytoscape software version 3.6.1, the visual networks of the "TCM drugs-Active Compounds-Targets-Diseases" and protein-protein interaction of the key targets of WTD for the treatment of OA were constructed. The core active compounds and the key targets obtained were molecularly docked and validated.Results: Analyses revealed 140 active compounds in WTD, 123 of which had a total of 163 corresponding targets. In addition, 331 differentially expressed genes and 227 OA-related targets were obtained. The interaction networks among 32 key targets were identified. The biological processes of WTD in treating OA mainly involved regulation of inflammatory factors, transcription of genetic materials, cell cycle, angiogenesis, and endocrine regulation. The signaling pathways involved mainly included TNF signaling pathway, rheumatoid arthritis signaling pathway, cancer-related signals, vascular endothelial growth factor signaling pathway, and osteoclast differentiation signaling pathways. Molecular docking showed that 7 core compounds including quercetin and kaempferol had strong affinities with key target proteins for the WTD treatment of OA.Conclusions: WTD with multi-component can treats OA through multi-pathway. Its active compounds, including quercetin and kaempferol, can exert their therapeutic effects on OA by acting on TNF, PTGS2, MMP2, IL-6, IL-1β, and other key targets to regulate inflammation, immunity, autophagy, and endocrinerelated signaling pathways.

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Guidelines for the diagnosis and treatment of osteoarthritis in China (2019 edition)

Cited by 86 publications

References 109 publications

Comparing the efficacy of non-invasive physical therapy in improving pain and joint function of knee osteoarthritis

Comparing the efficacy of non-invasive physical therapy in improving pain and joint function of knee osteoarthritis

Efficacy of combined use of glycosaminoglycan peptide complex for intramuscular administration and oral diacerein in osteoarthritis: evaluation according to an observational multicenter clinical trial

Molecular mechanism of Wutou Decoction in the treatment of osteoarthritis: a bioinformatics and molecular docking study

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