Guidelines for management of Bowen's disease

Cox, Neil; Eedy, D.J.; Morton, C.A.

doi:10.1046/j.1365-2133.1999.03100.x

Cited by 168 publications

(166 citation statements)

References 87 publications

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“…Due to inconsistencies of different treatment regimens used at different centres, their relative comparison for effectiveness is difficult as published data do not fully control for factors such as size and site. A useful modality of treatment, especially in small lesions over the sites which have a delayed healing, perineal lesions, and digital lesions is surgical excision 4,11 . Various studies have demonstrated an early 100% cure rate for surgical excision, as was seen in a clinicopathological study of 47 cases of perianal Bowen's disease excision by Marchesa et al 13 .…”

Section: Discussionmentioning

confidence: 99%

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Bowen’s Disease in Kashmir - A Pilot Study

Bhat¹,

Manzoor²,

Syed³

et al. 2018

IJCMR

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Section: Discussionmentioning

confidence: 99%

“…Usually BD is a solitary lesion, but in 10% to 20% of cases, it occurs at multiple sites 1,2 . 3% to 5% of extragenital lesions and about 10% of genital lesions may progress into an invasive carcinoma 3,4 . In the Caucasian population, BD is quite commonly seen, with an incidence of 1.42 per 1000 in some populations 5 .…”

Section: Introductionmentioning

confidence: 99%

Bowen’s Disease in Kashmir - A Pilot Study

Bhat¹,

Manzoor²,

Syed³

et al. 2018

IJCMR

View full text Add to dashboard Cite

“…Wahl bei klei nen, so li tär-en M. Bo wen ge se hen [5]. In ei ner re trospek ti ven Stu die wur de eine Re mis si ons rate von 93 mit die sem Ver fah ren er reicht [3], teil wei se wird die Hei lungs ra te mit bis zu 98 an ge ge ben.…”

Section: Kü Ret Ta Geunclassified

“…Die Kryo the ra pie, Ex zi si on, Kü ret ta ge mit Elek tro kau ter, La ser be hand lung, 5-FU und PDT wei sen bei der The ra pie des M. Bo wen alle ähn li che Re zi divra ten von 5-10 auf, und kei ne The ra piemög-lich keit ist für alle kli ni sche Si tua tio nen den an de ren über le gen [5].…”

Section: Aus Wahl Der the Ra Pie Artunclassified

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Therapieoptionen bei epithelialen Hauttumoren

2005

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There has been worldwide a significant rise in the incidence of epithelial skin tumors and their precursors in the past years with an increased number of younger patients affected. The risk factors are identified. The choice of the appropriate treatment for each individual is crucial. Major consideration include high cure rate, low long-term recurrence rate and few side effects. In the following article different therapeutic approaches for actinic keratoses, Bowen's disease, basal cell carcinoma and squamous cell carcinoma are presented and analysed.

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Comparison of Topical Methyl Aminolevulinate Photodynamic Therapy With Cryotherapy or Fluorouracil for Treatment of Squamous Cell Carcinoma In Situ

Morton¹,

Horn²,

Leman³

et al. 2006

Arch Dermatol

235

229

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To compare the efficacy, tolerability, and cosmetic outcome of photodynamic therapy (PDT) using topical methyl aminolevulinate with cryotherapy or topical fluorouracil for treatment of squamous cell carcinoma in situ. Design: Randomized, placebo-controlled study, with follow-up at 3 and 12 months after last treatment. Setting: Forty outpatient dermatology centers in 11 European countries. Patients: Random sample of 225 patients with histologically confirmed squamous cell carcinoma in situ (lesion size, 6-40 mm) and no evidence of progression. Interventions: Treatment with PDT with methyl aminolevulinate (160 mg/g; n=96) or matching placebo cream (n=17), cryotherapy (n=82), or topical fluorouracil (5% cream; n=30). Methyl aminolevulinate or placebo cream was applied for 3 hours before illumination with broadband red light (75 J/cm 2 , 570-670 nm). Treatment was repeated 1 week later. Cryotherapy was performed with liquid nitrogen spray. Fluorouracil was applied for 4 weeks. Lesions with a partial response at 3 months were retreated. Main Outcome Measures: Clinically verified complete response of lesions; blinded and on-site assessment of cosmetic outcome (4-point rating scale). Results: At 12 months, the estimated sustained lesion complete response rate with methyl aminolevulinate PDT was superior to that with cryotherapy (80% vs 67%; odds ratio, 1.77; 95% confidence interval, 1.01-3.12; P=.047), and better than that with fluorouracil (80% vs 69%; odds ratio, 1.64; 95% confidence interval, 0.78-3.45; P=.19). Cosmetic outcome at 3 months was good or excellent in 94% of patients treated with methyl aminolevulinate PDT vs 66% with cryotherapy and 76% with fluorouracil, and was maintained at 12 months. Conclusion: Methyl aminolevulinate PDT is an effective treatment option for squamous cell carcinoma in situ, with excellent cosmesis.

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Guidelines for management of Bowen's disease

Cited by 168 publications

References 87 publications

Bowen’s Disease in Kashmir - A Pilot Study

Bowen’s Disease in Kashmir - A Pilot Study

Therapieoptionen bei epithelialen Hauttumoren

Comparison of Topical Methyl Aminolevulinate Photodynamic Therapy With Cryotherapy or Fluorouracil for Treatment of Squamous Cell Carcinoma In Situ

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