Guidelines for dyslipidemia management in India: A review of the current scenario and gaps in research

Misra, Sanjana; Lyngdoh, Tanica; Mulchandani, Rubina

doi:10.1016/j.ihj.2022.07.009

Cited by 7 publications

(9 citation statements)

References 69 publications

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“…This choice was based upon its specific utility for rheumatic and musculoskeletal diseases, including RA, as also in systemic lupus erythematosus (SLE) 36 that have been factored in its calculations and found to have maximum utility in Indian patients with RA to predict subclinical atherosclerosis. 37 Using the 'QRISK-3' calculator, 10-year risk for ASCVD was calculated and the patients were categorised under the following ASCVD-risk categories: In the second step, the patients were prescribed lipid-lowering drugs to achieve the following targets of LDL-C stratified in different risk categories as has been recommended by the Indian guidelines for lipid control: 17,18 • In those at 'very high ASCVD risk' LDL-C target to be achieved was <50 mg/dl.…”

Section: Treatment For Lipid Controlmentioning

confidence: 99%

“…12,13 Therefore, statin treatment for its prevention, mainly targeting low-density lipoprotein cholesterol (LDL-C), is the current treatment paradigm, 14 recommended by international/national (including India) recommendations/guidelines. [15][16][17][18] Since 1997, the additional role of inflammation, measured by high-sensitivity C-reactive protein (hs-CRP), as a causative factor for ASCVD has been extensively studied and reported by Braunwald's group at Harvard, led by Paul Ridker and colleagues including JUPITER study and the CANTOS trial, a proof-of-concept study. [19][20][21][22] These workers have defined achieving the blood level of hs-CRP (as a surrogate for systemic inflammation) for the prevention of ASCVD to be <2 mg/l.…”

Section: Treatment For Lipid Controlmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevention of Atherosclerotic Cardiovascular Disease in Rheumatoid Arthritis: Persistent Low-grade In-flammation May be an Impediment Needing Attention

Malaviya,

Bondge,

Prasad

2024

Indian Journal of Rheumatology

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Objective: To determine the status of ‘residual inflammatory risk’ (RIR) and ‘residual cholesterol risk’ (RCR) in patients with Rheumatoid Arthritis (RA) in remission with the aim of estimating their atheroscle-rotic cardiovascular disease (ASCVD) risk. Methods: The study included patients with RA in remission during their last two clinic visits on treatment with disease- mod-ifying anti-rheumatic drugs (DMARDs). Using the QRISK-3 calculator, participants were stratified into four risk categories for ASCVD: ‘Very high’, ‘High’, ‘Moderate’, and ‘Low’. Patients were prescribed lipid-lowering drugs targeting low-density lipoprotein cholesterol (LDL-C) levels to <50 mg/dl, <70 mg/dl, <100 mg/dl or <130 mg/dl, respectively. Those with a history of ASCVD before or during the follow-up period was excluded from the study. Multimorbidity were also recorded in all the patients. Results: The study included 130 patients with RA in remission. The results showed that despite being in remission and taking treatment for lipid control, 81 (62%) and 91 (70%) patients still had ‘RIR’ and ‘RCR’, respectively. Hypertension, hypothyroidism, type-2 diabetes mellitus and obesity were the common multimorbidity. Conclusions: Persistent RIR in 62% of patients despite being in remission, could possibly be due to the current ‘liberal’ definition of RA permitting hs-CRP level up to <10 mg/l, which is five-fold higher than the recommended <2 mg/l for ASCVD prevention. Hence it may be necessary to revise the definition of ‘remission’ in RA factoring in the suggested lower level of hs-CRP. Additionally, rheumatologists might need to be more vigilant in lipid management with appropriate patient education regarding RCR.

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Section: Treatment For Lipid Controlmentioning

confidence: 99%

Section: Treatment For Lipid Controlmentioning

confidence: 99%

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Prevention of Atherosclerotic Cardiovascular Disease in Rheumatoid Arthritis: Persistent Low-grade In-flammation May be an Impediment Needing Attention

Malaviya,

Bondge,

Prasad

2024

Indian Journal of Rheumatology

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“…Dyslipidaemia is an important risk factor for the development of ASCVD characterised by elevated total cholesterol/LDL-C, triglyceride or both or decreased HDL-C. 5 The pattern of dyslipidaemia in Asian Indians has been found to be different when compared to people of other ethnicities. Atherogenic dyslipidaemia characterised by high TG, low HDL-C and elevated small dense LDL (sdLDL) is more prevalent in Asian Indians.…”

Section: Introductionmentioning

confidence: 99%

Management of triglycerides, non-high density lipoprotein cholesterol and high density lipoprotein cholesterol

Zachariah

2024

Indian Heart Journal

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“…Increasing socioeconomic levels have resulted in a change in diet from a traditional diet to a western diet such as fast food and high-calorie fats, resulting in a high prevalence of hypercholesterolemia in the community. One effort to reduce lipid profiles is through specific interventions to nutrition education through counseling is very good in improving one's behavior (Misra et al, 2022). Nutrition counseling is a two-way activity process that aims to improve patient behavior so that it can overcome health and nutrition problems, which generally in the implementation of counseling can be combined to be more effective (Muñoz et al, 2024).…”

Section: Introductionmentioning

confidence: 99%

Nutrition Counseling, Lipid Profile Improvement and Weight Loss in Obese Patients with Dyslipidemia

Salman,

Hadi,

Ntau

et al. 2023

j. info kesehat.

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Obesity with dyslipidemia is a serious problem because it risks various degenerative and metabolic diseases. The prevalence of obesity in Indonesia continues to increase every year, currently in the adult population reaching 21.8%. To prevent the onset of degenerative diseases and metabolic disorders, it is important to control obesity with dyslipidemia through weight loss and lipid profile improvement. This study aims to determine the effect of nutritional counseling in losing weight and improving lipid profiles in obese patients with dyslipidemia. This is a pseudo-experimental study with One group Pre and Post Test Design. The initial stage was the identification of obesity and lipid profile. In 100 respondents identified as obese, total cholesterol, LDL and triglycerides were examined. 40 obese respondents with dyslipidemia were determined as samples. The second stage was nutrition counseling intervention. The third stage of evaluation is the re-measurement of body weight and lipid profile. The research result is only 30 respondents participated in the evaluation. Average initial body weight was 75.11 kg and final body weight was 73.14 kg. Average weight loss was 1.97 kg. Average initial cholesterol 233.20 mg/dL and final cholesterol 224.70 mg/dL. Average cholesterol reduction of 8.5 mg/dL. Average initial LDL 152.37 mg/dL and final LDL 139.47 mg/dL. Average decrease in LDL 12.9 mg/dL Average initial triglycerides 161.23 mg/dL and final triglycerides 143.97 mg/dL. The average decrease in triglycerides is 17.26 mg/dL. The statistical test results showed a p-value = 0.000. There is an effect of nutritional counseling on weight loss and improvement of lipid profiles of obese patients with dyslipidemia.

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Guidelines for dyslipidemia management in India: A review of the current scenario and gaps in research

Cited by 7 publications

References 69 publications

Prevention of Atherosclerotic Cardiovascular Disease in Rheumatoid Arthritis: Persistent Low-grade In-flammation May be an Impediment Needing Attention

Prevention of Atherosclerotic Cardiovascular Disease in Rheumatoid Arthritis: Persistent Low-grade In-flammation May be an Impediment Needing Attention

Management of triglycerides, non-high density lipoprotein cholesterol and high density lipoprotein cholesterol

Nutrition Counseling, Lipid Profile Improvement and Weight Loss in Obese Patients with Dyslipidemia

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