Guidelines for Cardiovascular Magnetic Resonance Imaging from the Korean Society of Cardiovascular Imaging—Part 3: Perfusion, Delayed Enhancement, and T1- and T2 Mapping

Im, Dong Jin; Hong, Su Jin; Park, Eun Ah; Kim, Eun Young; Jo, Yeseul; Kim, Jeong-Jae; Park, Chul Hwan; Yong, Hwan Seok; Lee, Jae Woo; Hur, Jee Hye; Yang, Dong Hyun; Lee, Bae Young

doi:10.3348/kjr.2019.0411

Cited by 15 publications

(8 citation statements)

References 58 publications

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“…Additionally, the DMD group had significantly faster heart rates, which may influence the generalizability of our T1 mapping results [ 32 ]. However, guidelines suggest that the effects of heart rate on T1 mapping are minimized with the sequence parameters used in this study [ 33 , 34 ]. Finally, we didn’t calculate ECV.…”

Section: Discussionmentioning

confidence: 99%

Global, segmental and layer specific analysis of myocardial involvement in Duchenne muscular dystrophy by cardiovascular magnetic resonance native T1 mapping

et al. 2021

Journal of Cardiovascular Magnetic Resonance

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Background Progressive cardiomyopathy accounts for almost all mortality among Duchenne muscular dystrophy (DMD) patients.‍ Thus, our aim was to comprehensively characterize myocardial involvement by investigating the heterogeneity of native T1 mapping in DMD patients using global and regional (including segmental and layer-specific) analysis across a large cohort. Methods We prospectively enrolled 99 DMD patients (8.8 ± 2.5 years) and 25 matched male healthy controls (9.5 ± 2.5 years). All subjects underwent cardiovascular magnetic resonance (CMR) with cine, T1 mapping and late gadolinium enhancement (LGE) sequences. Native T1 values based on the global and regional myocardium were measured, and LGE was defined. Results LGE was present in 49 (49%) DMD patients. Global native T1 values were significantly longer in LGE-positive (LGE +) patients than in healthy controls, both in basal slices (1304 ± 55 vs. 1246 ± 27 ms, p < 0.001) and in mid-level slices (1305 ± 57 vs. 1245 ± 37 ms, p < 0.001). No significant difference in global native T1 was found between healthy controls and LGE-negative (LGE−) patients. In segmental analysis, LGE + patients had significantly increased native T1 in all analyzed segments compared to the healthy control group. Meanwhile, the comparison between LGE− patients and healthy controls showed significantly elevated values only in the basal anterolateral segment (1273 ± 62 vs. 1234 ± 40 ms, p = 0.034). Interestingly, the epicardial layer had a significantly higher native T1 in LGE− patients than in healthy controls (p < 0.05), whereas no such pattern was noticed in the global myocardium. Epicardial layer native T1 resulted in the highest diagnostic performance for distinguishing between healthy controls and DMD patients in receiver operating curve analyses (area under the curve [AUC] 0.84 for basal level and 0.85 for middle level) when compared to global native T1 and endocardial layer native T1. Conclusions Myocardial regional native T1, particularly epicardial native T1, seems to have potential as a novel robust marker of very early cardiac involvement in DMD patients. Trial registration: Chinese Clinical Trial Registry (http://www.chictr.org.cn/index.aspx) ChiCTR1800018340, 09/12/2018, Retrospectively registered.

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Section: Discussionmentioning

confidence: 99%

Global, segmental and layer specific analysis of myocardial involvement in Duchenne muscular dystrophy by cardiovascular magnetic resonance native T1 mapping

et al. 2021

Journal of Cardiovascular Magnetic Resonance

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“…For the feature tracking strain analysis, dedicated software was used (Vitrea, Canon Medical Systems Corporation, Otawara, Tochigi, Japan). To assess the amount of fibrosis on LGE, enhanced myocardium was defined using the planimetry method [ 26 , 27 ]. A strain analysis was performed to determine the endocardial and epicardial borders of the myocardial tissue in each cine image, and peak global radial strain (GRS) and peak global circumferential strain (GCS) were calculated using short-axis cine CMR.…”

Section: Methodsmentioning

confidence: 99%

Cardiovascular magnetic resonance assessment of coronary flow reserve improves risk stratification in heart failure with preserved ejection fraction

Kato

Fukui

Kodama

et al. 2021

Journal of Cardiovascular Magnetic Resonance

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Background Coronary microvascular dysfunction (CMD) has been proposed as a novel mechanism for the pathophysiology of heart failure (HF) with preserved ejection fraction (HFpEF). Recent studies have suggested the potential utility of coronary flow reserve (CFR) as a marker of CMD in patients with HFpEF. Phase contrast (PC) cine cardiovascular magnetic resonance (CMR) of the coronary sinus has emerged as a non-invasive method to quantify CFR. We aimed to investigate the prognostic value of CMR-derived CFR in patients with HFpEF. Methods Data from 163 HFpEF patients (73 ± 9 years; 86 [53%] female) were retrospectively analyzed. Coronary sinus blood flow was measured in all patients, and myocardial blood flow was calculated as coronary sinus blood flow divided by left ventricular mass. CFR was calculated as the myocardial blood flow during adenosine triphosphate infusion divided by that at rest. Adverse events were defined as all-cause death and hospitalization due to HF exacerbation. Event-free survival stratified according to CFR < 2.0 was estimated with Kaplan–Meier survival methods and Log-rank test. Results During a median follow-up of 4.1 years, 26 patients (16%) experienced adverse events. CMR-derived CFR was significantly lower in HFpEF with adverse events compared with those without (1.93 ± 0.38 vs. 2.67 ± 0.52, p < 0.001). On a Kaplan Meier curve, the rates of adverse events were significantly higher in HFpEF patients with CFR < 2.0 compared with HFpEF with CFR ≥ 2.0 (p < 0.001). The area under the curve of CFR for predicting adverse events was significantly higher than that of LGE (0.881 vs. 0.768, p = 0.037) and GLS (0.881 vs. 0.747, p = 0.036). Conclusions CFR assessed using coronary sinus PC cine CMR may be useful as a non-invasive prognostic marker for HFpEF patients.

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“…myocardial infarction, cardiac sarcoidosis, tako-tsubo cardiomyopathy and heart transplant rejection. 6 The diagnostic value of T1 mapping has been investigated in a variety of myocardial pathologies including acute myocarditis, [7][8][9][10] diffuse myocardial fibrosis, 11 dilated cardiomyopathy, 12 hypertrophic cardiomyopathy, 13 cardiac amyloidosis, [14][15][16][17] and Fabry disease. [18][19][20] T1 mapping has also been evaluated as a prognostic tool in various pathologies including cardiac amyloidosis, 17 systemic sclerosis, 21 heart failure with preserved ejection fraction, 22 aortic stenosis 23 and myocardial infarction.…”

mentioning

confidence: 99%

Global and Regional Test–Retest Reproducibility of Native T1 and T2 Mapping in Cardiac Magnetic Resonance Imaging

Böttcher

Lorbeer

Stöcklein

et al. 2021

Magnetic Resonance Imaging

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BackgroundMapping of T1 and T2 relaxation times in cardiac MRI is an invaluable tool for the diagnosis and risk stratification of a wide spectrum of cardiac diseases.PurposeTo investigate the global and regional reproducibility of native T1 and T2 mapping and to analyze the influence of demographic factors, physiological parameters, slice position, and myocardial regions on reproducibility.Study TypeProspective single‐center cohort‐study.PopulationFifty healthy volunteers (29 female, 21 male) with a mean age of 39.4 ± 13.7 years.Field strength/SequenceEach volunteer was investigated twice at 1.5 T using a modified look‐locker inversion‐recovery (MOLLI) sequence (T1 mapping) and a T2‐prepared steady‐state free precession (SSFP) sequence (T2 mapping).AssessmentGlobal T1 and T2 values were quantified for the entire left ventricle in three short‐axis slices. Regional T1 and T2 values were measured for each myocardial segment and for myocardial segments grouped by slice position and anatomical region.Statistical TestsTest–retest reproducibility was assessed using intraclass correlation coefficient (ICC) and Bland–Altman statistics. A P value < 0.05 was considered statistically significant.ResultsReproducibility was good for global T1 values (ICC 0.88) and excellent for global T2 values (ICC 0.91). Reproducibility of T1 values was excellent (ICC 0.91) for midventricular slice and good for apical (ICC 0.86) and basal slice (ICC 0.81). Reproducibility of T1 mapping values was highest in the septum (ICC 0.90) compared to the anterior (0.81), lateral (0.86), and inferior (0.86) wall. For T2 mapping, reproducibility was good for all slice positions (ICC 0.86 for midventricular, 0.83 for basal, and 0.80 for apical slice). Reproducibility of T2 mapping was significantly lower for the inferior wall (ICC 0.58) than for septum (0.89), anterior (0.85), and lateral (0.87) wall.Data ConclusionNative T1 and T2 mapping has good to excellent reproducibility with significant regional differences.Evidence Level2Technical EfficacyStage 2

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Guidelines for Cardiovascular Magnetic Resonance Imaging from the Korean Society of Cardiovascular Imaging—Part 3: Perfusion, Delayed Enhancement, and T1- and T2 Mapping

Cited by 15 publications

References 58 publications

Global, segmental and layer specific analysis of myocardial involvement in Duchenne muscular dystrophy by cardiovascular magnetic resonance native T1 mapping

Global, segmental and layer specific analysis of myocardial involvement in Duchenne muscular dystrophy by cardiovascular magnetic resonance native T1 mapping

Cardiovascular magnetic resonance assessment of coronary flow reserve improves risk stratification in heart failure with preserved ejection fraction

Global and Regional Test–Retest Reproducibility of Native T1 and T2 Mapping in Cardiac Magnetic Resonance Imaging

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