“…Some problems in general dimension include organizational challenges like organizational culture, support of high-level management; technological barriers such as lack of ICT and mobile infrastructure [52]; human challenges, for example, lack of trained and skilled personnel at health care centers in this field [28], user attitudes, technology acceptance [53,54], user characteristics like age, economic, social, and educational status [55]; and threats to confidentiality and privacy, legal, ethical, and administrative barriers, costs of system implementation and maintenance [28], dependence on IT [56], the cost of updating, costly modern systems [57], sufficient investment, delays in implementation and providing electronic devices and software [58]. Some barriers from specific aspects also include problems in interoperability between other health systems and information technology tools, poor and inappropriate design and implementation [59], effect on face-to-face communication between health care providers and patient [60], causes omission of human relationship and the negative effects of technology on relationships between individuals and social processes [56], designing of mHealth services content [55], failure to meet targets [58], virtual information control [61], medical errors due to malfunctioning of system [62], fault documentation [59] like data manipulation and rewriting, misrepresentation, and violation of patients' legal rights. Difficulties related to telecommunication industry such as reliability, sustainability of connections, sudden interruptions of telecommunication networks [63], device and sensor type that can be used, type of data and language presentation [56], scalability in terms of data rate, power and energy consumption; antenna design, quality of service, energy efficiency [64,65] wearable devices weight, type of devices that used for patient monitoring that sometimes lead to problem in data processing, accuracy of gathering information depends on where data were collected, and user training to use wearable system [66].…”