Guided Tissue Regeneration Treatment Yields Better Results in Class II Furcations in the Mandible Than in the Maxilla: A Retrospective Study

Abstract

Absorbable porcine collagen membrane with a bovine bone graft can be considered for regenerative treatment in periodontal class II furcation defects. We evaluated the clinical efficacy of guided tissue regeneration (GTR) treatment with bovine bone xenograft and a porcine collagen membrane in molars with class II furcations. Probing depth (PD), clinical attachment level (CAL), and bone level (BL) were recorded at baseline and at 3, 6, and 9 months postoperatively. Thirty class II furcation defects from the lower and upper molars were assessed. Significant improvements in PD and CAL were observed from baseline to 9 months in all groups (p < 0.01). BL improved in all groups except group A in the upper molars in radiographic assessment (p < 0.05). The lower and upper molars showed PD reduction of 50.5% ± 7.44% and 46.2% ± 11.2%, respectively, at 9 months (p = 0.044). In furcations of 1–3 mm, the lower and upper molars showed PD reductions of 51.2% ± 4.49% and 36.5% ± 16.14%, respectively (p = 0.035). The lower and upper molars showed a CAL gain of 51.1% ± 4.64% and 33.6% ± 18.8%, respectively (p = 0.037). Thus, GTR with bovine bone graft and porcine collagen membrane yielded good results in class II furcations, with better results in the lower than in the upper molars.

Evaluating Change of Marginal Bone Height with Cone-Beam Computed Tomography Following Surgical Treatment with Guided Tissue Regeneration (Bone Grafting) or Access Flap Alone: A Retrospective Study

“…The present study revealed that GTR in the mandible yielded better bone gain than in the maxilla. These outcomes are similar to those reported by Odontuya et al [ 25 ]. Other researchers explained that this difference was due to the complex morphology and accessibility of molars such as root cuvature and furcations [ 26 , 27 ].…”

Identifying Differences in Molecular Characteristics Relevant for Remodeling of Periodontal Ligament Stem Cells from the Upper and Lower Jaw

“…In 2021 Dorj, Lee et al discovered that guided tissue regeneration treatment yields to better results in severe vertical bone loss in the molar region (class II furcations) in the mandible than in the maxilla [ 15 ]. Furthermore, stem cell properties of PDLSC isolated from third molars of maxilla and mandible show intrinsic differences in proliferation and plasticity [ 16 ].…”

Angiogenic potential in periodontal stem cells from upper and lower jaw: A pilot study

“…9 According to research of Dorj et al, guided tissue regeneration therapy produces better outcomes in terms of severe vertical bone loss in the mandible's molar region (class II furcations) than in the maxilla. 10 Furthermore, stem cell properties of PDLSC isolated from third molars of maxilla and mandible show intrinsic differences in proliferation and plasticity. 11 In this study, we isolated PDLSC from maxilla and mandible of the same patients and compared the angiogenic potential related to localization of the cells.…”

“…Healing may be impacted by variations between the upper versus lower jaw's odontogenic development and odontogenesis, blood supply, and innervation 9 . According to research of Dorj et al, guided tissue regeneration therapy produces better outcomes in terms of severe vertical bone loss in the mandible's molar region (class II furcations) than in the maxilla 10 . Furthermore, stem cell properties of PDLSC isolated from third molars of maxilla and mandible show intrinsic differences in proliferation and plasticity 11 …”