Guided tissue regeneration techniques involving blood-derived products in periradicular surgery: a systematic review and meta-analysis protocol

Baniulyte, Gabriele; Ali, Kamran; Burns, Lorna

doi:10.11124/jbies-21-00019

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…The review has also been registered with PROSPERO (registration number CRD42020222663) to ensure transparency and prevent any inadvertent duplication of research efforts. The protocol for this review was published by JBI 33 to provide clarity and avoid unnecessary repetition.…”

Section: Methodsmentioning

confidence: 99%

Utilising blood-derived products for guided tissue regeneration in periradicular surgery: a systematic review and meta-analysis

Baniulyte,

Burns,

Ali

2024

MaterialsOpenRes

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Background Since 1982, guided tissue regeneration (GTR) has become increasingly popular. The recent progress in GTR research focuses on the application of blood-derived products. However, no comprehensive systematic review has been conducted to assess its effectiveness specifically in periradicular surgery. Therefore, the aim of this review was to analyse the outcomes of periradicular with GTR using blood-derived products compared to standard periradicular surgery. Methods This review was based on randomised controlled trials comparing periradicular surgery in conjunction with GTR with blood-derived products and the standard periapical surgery. The databases searched included Embase, MEDLINE, Cochrane CENTRAL, and Dentistry and Oral Sciences Source, with the most recent search conducted on December 16th, 2022. Additionally, reference lists of similar systematic reviews were examined, while international trials registries and repositories were consulted for unpublished studies. Two blinded independent reviewers carried out the screening and the included studies underwent critical appraisal. The findings are reported in accordance with the PRISMA guidelines. Results A total of 261 publications were initially reviewed based on their title and abstract, resulting in seventeen studies that underwent full-text screening. At this stage, 14 studies were excluded, leaving three randomised controlled trials to be included. These trials involved a total of 85 patients. A meta-analysis was conducted for the outcome of healing. The overall treatment effect was 0.78 (95% CI 0.18 to 3.34), indicating a preference towards the control group. Conclusion Based on a meta-analysis of three studies, there was no statistically significant distinction observed in terms of healing between the GTR involving blood-derived products and standard procedure groups. However, critical appraisal revealed indirectness and imprecision, resulting in a certainty rating of 'low'. Thus, additional robust evidence is necessary to support the utilisation of blood-derived products in GTR techniques to enhance periradicular surgery outcomes. Systematic review registration number PROSPERO CRD42020222663.

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Section: Methodsmentioning

confidence: 99%

Utilising blood-derived products for guided tissue regeneration in periradicular surgery: a systematic review and meta-analysis

Baniulyte,

Burns,

Ali

2024

MaterialsOpenRes

Self Cite

View full text Add to dashboard Cite

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“…The report observed Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA 2020) checklists (Appendix I and II in Supplementary Data les) [33]. The review title has been registered with PROSPERO (registration number CRD42020222663) and the protocol was published in a peer-reviewed journal [34].…”

Section: Methodsmentioning

confidence: 99%

Guided tissue regeneration techniques involving blood-derived products in periradicular surgery: a systematic review and meta-analysis

Baniulyte

Burns

Ali

2023

Preprint

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Background: Guided tissue regeneration (GTR) has been gaining popularity in dentistry as an aid to surgical techniques since 1982. The latest advancement in the GTR discipline examines the use of blood-derived products, but no systematic review had been carried out to date on its use in periradicular surgery. Therefore, the objective of this review was to evaluate the clinical outcomes of standard periradicular surgery versus periradicular surgery employing GTR techniques involving blood-derived products. Methods: Randomised controlled trials investigating the outcomes of GTR techniques involving blood-derived products versus standard periradicular surgery technique, were included for review. Studies were excluded if they contain patients who have previously undergone periradicular surgery or treatment was carried out on unrestorable teeth (i.e., due to periodontal disease or root fractures). The databases MEDLINE, Embase, Dentistry and Oral Sciences Source, and Cochrane CENTRAL were used to locate published reports of studies, last searched on 16th December 2022. Reference lists of relevant past systematic reviews were used to identify further studies. Unpublished studies were sought using international trials registries and repositories. Two blinded reviewers carried out independent screening of records for inclusion and the selected studies were critically appraised using Joanna Briggs Institute critical appraisal tool prior to data extraction and synthesis. The results are presented in accordance with PRISMA guidelines. Results: Two-hundred and sixty-one records were screened on title and abstract, and 17 studies were further screened against full text. Fourteen studies were excluded at this stage and 3 randomised controlled trials were included in the systematic review with a total of 85 patients. Meta-analysis was undertaken for the outcome of healing. The overall treatment effect was 0.78 (95% CI 0.18 to 3.34), favouring control group. Discussion: The meta-analysis of 3 studies showed no significant difference in healing between intervention and control groups. Critical appraisal of the included trials identified deficiencies in indirectness and imprecision, downgrading the overall certainty to ‘low’. Therefore, more strong evidence is required to recommend routine use blood derived products to improve the clinical outcomes of periradicular surgery in conjunction with guided tissue regeneration.

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Section: Methodsmentioning

confidence: 99%

Guided Tissue Regeneration Techniques Involving Blood-Derived Products in Periradicular Surgery: A Systematic Review and Meta-Analysis

Baniulyte

Burns

Ali

2023

Preprint

View full text Add to dashboard Cite

Guided tissue regeneration techniques involving blood-derived products in periradicular surgery: a systematic review and meta-analysis protocol

Cited by 5 publications

References 18 publications

Utilising blood-derived products for guided tissue regeneration in periradicular surgery: a systematic review and meta-analysis

Utilising blood-derived products for guided tissue regeneration in periradicular surgery: a systematic review and meta-analysis

Guided tissue regeneration techniques involving blood-derived products in periradicular surgery: a systematic review and meta-analysis

Guided Tissue Regeneration Techniques Involving Blood-Derived Products in Periradicular Surgery: A Systematic Review and Meta-Analysis

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