Guided tissue regeneration in intrabony defects using an experimental bioresorbable polydioxanon (PDS) membrane

Abstract

This 24-month study indicates that the PDS and PLA membranes can provide similar favorable regeneration results in deep intrabony periodontal defects, although considerably more postoperative membrane exposures have to be expected in PDS treated sites.

Digital subtraction radiographic analysis of the combination of bioabsorbable membrane and bovine morphogenetic protein pool in human periodontal infrabony defects

“…In both test and controls sites, the clinical attachment gain was accompanied by significant gain in bone density. The radiographic alterations were higher than those of previous studies 3,5,6,8 . Nevertheless, these results must be interpreted with caution because b-TCP is radiopaque and by radiographic methods, one does not distinguish whether it was replaced by vital bone.…”

“…These results were lower than those of other studies in which subtraction analysis was used 5,6,12,18 to evaluate the results of regenerative therapy. Nevertheless, the time factor must be considered, since the alterations in the degree of bone tissue mineralization are directly related to the alterations in the calcium and phosphate levels, which may require a considerable time to become evident due to biomaterial incorporation and bone remodeling 19 .…”

“…Nevertheless, the time factor must be considered, since the alterations in the degree of bone tissue mineralization are directly related to the alterations in the calcium and phosphate levels, which may require a considerable time to become evident due to biomaterial incorporation and bone remodeling 19 . In the present study, the evaluation period was a time interval of 6 months, while in other studies, the periods of analysis exceeded 6 months 5-8,13,14,18 . This may at least partly explain the lower gain in density observed in this study.…”

“…There are few studies involving the treatment of infra-osseous defects by means of RTG with an absorbable barrier, associated or not with other regenerative procedures, which included radiographic subtraction analyses 5,6,8,12,18 . Although the digitized image offers more resources than conventional analysis, such as the possibility of manipulating the image to adjust the gray levels and calculating the quantification of the area of density, as is the case with the conventional method, it consists of subjective analysis.…”

Treatment of intrabony defects with guided tissue regeneration in aggressive periodontitis: clinical outcomes at 6 and 12 months

“…Moreover, the ΔCAL was also found to be reduced at the sites with membrane exposure, compared to those with the nonexposed membrane. Such exposure has previously been reported in several GTR studies using various types of nonresorbable and resorbable membranes [29,30,31,32,33,34]. A meta-analysis of the effect of membrane exposure on the clinical outcome, analysing five studies where either resorbable or non-resorbable membranes were used, demonstrated that the sites with exposed membrane had a significantly lower ΔCAL (4.22 [0.15] mm) than the sites without membrane exposure (4.69 [0.13] mm) (p < 0.05) [35].…”