Guided Tissue and Bone Regeneration Membranes: A Review of Biomaterials and Techniques for Periodontal Treatments

Abstract

This comprehensive review provides an in-depth analysis of the use of biomaterials in the processes of guided tissue and bone regeneration, and their indispensable role in dental therapeutic interventions. These interventions serve the critical function of restoring both structural integrity and functionality to the dentition that has been lost or damaged. The basis for this review is laid through the exploration of various relevant scientific databases such as Scopus, PubMed, Web of science and MEDLINE. From a meticulous selection, relevant literature was chosen. This review commences by examining the different types of membranes used in guided bone regeneration procedures and the spectrum of biomaterials employed in these operations. It then explores the manufacturing technologies for the scaffold, delving into their significant impact on tissue and bone regenerations. At the core of this review is the method of guided bone regeneration, which is a crucial technique for counteracting bone loss induced by tooth extraction or periodontal disease. The discussion advances by underscoring the latest innovations and strategies in the field of tissue regeneration. One key observation is the critical role that membranes play in guided reconstruction; they serve as a barrier, preventing the entry of non-ossifying cells, thereby promoting the successful growth and regeneration of bone and tissue. By reviewing the existing literature on biomaterials, membranes, and scaffold manufacturing technologies, this paper illustrates the vast potential for innovation and growth within the field of dental therapeutic interventions, particularly in guided tissue and bone regeneration.

Regeneration of Rabbit Calvarial Defects with Combination of Stem Cells and Enamel Matrix Derivative: A Microcomputed Tomography and Histological Evaluation Comparing Two- and Three-Dimensional Cell Constructs

“…This ability to maintain space was critical to establishing a controlled environment to evaluate the regenerative effects of the treatment being tested [ 26 , 27 ]. This membrane plays an important role in the management of periodontal defects, especially in the realm of guided tissue regeneration and guided bone regeneration methodologies [ 28 ]. In guided tissue regeneration applications, the membrane is used to treat defects within the periodontal ligament and alveolar bone [ 29 ].…”

“…In one study, in vivo micro-CT was utilized to analyze bone remodeling in a rat model with calvarial defects, demonstrating the utility of micro-CT in tracking the dynamic process of bone remodeling over time, a critical factor in understanding the mechanisms of bone healing and regeneration [ 22 ]. Additionally, another investigation employed in vivo micro-CT to examine angiogenesis in rat calvarial flat bone defects, suggesting that this methodology was pivotal for assessing the formation and progression of new blood vessels during bone regeneration, showcasing micro-CT’s effectiveness in providing detailed insights into the physiological processes involved in bone healing [ 28 ].…”

Cissus Extracts in Dentistry: A Comprehensive Review on its Untapped Potential

“…[ 5 ] According to Brahmkshatriya H. et al , C. quadrangularis accelerated the healing of fractured jaw bones and helped to reduce pain and edema. [ 6 ]…”

Resorbable GBR Scaffolds in Oral and Maxillofacial Tissue Engineering: Design, Fabrication, and Applications

“…[88, [92][93][94][95][96][97] PGA: poly (glycolic acid); PLA: poly (lactic acid); PCL: polycaprolactone; PGS: poly (glycerol sebacate); PEG: poly ethylene glycol.…”