Guided internet-based cognitive behavioral therapy for obsessive-compulsive disorder: A multicenter randomized controlled trial in Japan

Matsumoto, Kazuki; Hamatani, Sayo; Makino, Takuya; Takahashi, Jumpei; Suzuki, Futoshi; Ida, Tomoko; Hamamura, Shoko; Takiguchi, Shinichiro; Tomoda, Akemi; Omori, Ichiro M; Kosaka, Hirotaka; Shinno, Seina; Ikai, Tomoki; Hayashi, Hiroyuki; Katayama, Hiroto; Shiko, Yuki; Ozawa, Yoshihito; Kawasaki, Yohei; Sutoh, Chihiro; Shimizu, Eiji

doi:10.1016/j.invent.2022.100515

Cited by 16 publications

(19 citation statements)

References 47 publications

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“…ICBT is employed widely in Sweden [ 61 ], but not in Japan [ 62 ]. In addition, some recent clinical trials have suggested that ICBT is feasible and effective for anxiety disorders in Japan [ 63 , 64 ]. Therefore, Japan should accelerate efforts to introduce and implement this intervention as broadly as Sweden.…”

Section: Discussionmentioning

confidence: 99%

Impact of post-COVID conditions on mental health: a cross-sectional study in Japan and Sweden

et al. 2022

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Background Due to the coronavirus disease 2019 (COVID-19) pandemic, people have undermined their mental health. It has been reported that post-COVID conditions at a certain rate. However, information on the mental health of people with post-COVID conditions is limited. Thus, this study investigated the relationship between post-COVID conditions and mental health. Methods Design of the present study was an International and collaborative cross-sectional study in Japan and Sweden from March 18 to June 15, 2021. The analyzed data included 763 adults who participated in online surveys in Japan and Sweden and submitted complete data. In addition to demographic data including terms related to COVID-19, psychiatric symptoms such as depression, anxiety, and post-traumatic stress were measured by using the fear of COVID-19 scale (FCV-19S), Patient Health Questionnaire-9 (PHQ-9), General Anxiety Disorder-7 item (GAD-7), and Impact of Event Scale-Revised (IES-R). Results Of the 135 COVID-19 survivors among the 763 total participants, 37.0% (n = 50/135) had COVID-19-related sequelae. First, the results of the Bonferroni-corrected Mann Whitney U test showed that the group infected SARS-CoV-2 with post-COVID conditions scored significantly higher than those without one and the non-infected group on all clinical symptom scales (P ≤ .05). Next, there was a significant difference that incidence rates of clinical-significant psychiatric symptoms among each group from the results of the Chi-squared test (P ≤ .001). Finally, the results of the multivariate logistic model revealed that the risk of having more severe clinical symptoms were 2.44–3.48 times higher among participants with post-COVID conditions. Conclusion The results showed that approximately half had some physical symptoms after COVID-19 and that post-COVID conditions may lead to the onset of mental disorders. Trial registration The ethics committee of Chiba University approved this cross-sectional study (approval number: 4129). However, as no medical intervention was conducted, a clinical trial registration was not necessary.

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Section: Discussionmentioning

confidence: 99%

Impact of post-COVID conditions on mental health: a cross-sectional study in Japan and Sweden

et al. 2022

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“…When compulsions are accompanied by a depressive mood, it can interfere with the completion of homework assignments and the development of therapeutic habits during ERP treatment. Combining antidepressants and psychotherapy for OCD patients who have significant depressive symptoms may be more effective than monotherapy ( 50 ). In particular, for patients with severe obsessive-compulsive co-morbid depression who do not respond well to therapy alone, a combination of CBT involving ERP and SSRIs is frequently recommended ( 8 ).…”

Section: Discussionmentioning

confidence: 99%

The effectiveness of exposure and response prevention combined with pharmacotherapy for obsessive-compulsive disorder: A systematic review and meta-analysis

Mao

et al. 2022

Front. Psychiatry

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ObjectiveTo systematically evaluate the effectiveness of exposure and response prevention (ERP) combined with medication on obsessive-compulsive disorder (OCD).MethodsPubMed, Web of Science, EBSCO, Cochrane, Embase, and Science Direct databases were searched to include randomized controlled trials of ERP combined with medication for OCD that met the criteria. The Yale Brown Obsessive Compulsive Scale was used as the primary outcome indicator, and Depression scales were used as secondary outcome indicators. An evaluation of bias risk was conducted to identify possible sources of bias based on methodological and clinical factors. Review Manager 5.3 and Stata 16.0 software was used to perform meta-analysis of the extracted data.ResultsA total of 21 studies with 1113 patients were included. Meta-analysis showed that ERP combined with medication therapy was significantly better than medication therapy alone including selective serotonin reuptake inhibitors, clomipramine and risperidone (MD = –6.60, 95% CI: –8.35 to –4.84, P < 0.00001), but D-cycloserine (DCS) drugs do not enhance the effect of ERP intervention in patients with OCD (MD = 0.15, 95% CI: –0.87 to 1.17, P = 0.77). There is more significant maintenance by combined treatment method of medication plus ERP than medication treatment alone during the follow-up period (MD = –7.14, 95% CI: –9.17 to –5.10, P < 0.00001). DCS drugs did not enhance the effect of ERP intervention on depression in patients with OCD (SMD = –0.08, 95% CI: –0.31 to 0.15, P = 0.50). ERP combined with drug improved patients’ depression levels significantly better than providing drug alone (SMD = –0.40, 95% CI: –0.68 to –0.11, P = 0.006).ConclusionPatients with OCD have significant improvement in symptoms of obsessive-compulsive disorder and depression when ERP is combined with medication, however, not enough to prove that DCS can enhance ERP effectiveness.

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“…The first and second authors (SH and KM) designed this ICBT program so that the number of characters, linguistic expressions, concepts, symbols, metaphors, and dietary content would be familiar to Japanese patients. The team has experience of building ICBT programs for other mental disorders—anorexia nervosa ( 21 ) and obsessive-compulsive disorder ( 22 ). This treatment protocol was designed completely based on a face-to-face CBT manual created by SH and KM.…”

Section: Methodsmentioning

confidence: 99%

Development of a culturally adaptable internet-based cognitive behavioral therapy for Japanese women with bulimia nervosa

Hamatani

Matsumoto²,

Ishibashi³

et al. 2022

Front. Psychiatry

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BackgroundThe process of cultural adaptation of internet-based cognitive behavioral therapy (ICBT) programs for bulimia nervosa (BN) have rarely been reported despite the potential influence of cultural adaptation of psychosocial interventions on therapeutic response.AimThis study aimed to illustrate development process of an ICBT program for Japanese women with bulimia nervosa (BN).MethodsA mixed methods approach was used to assess cultural adaptation of the prototype of an original ICBT program by using the Cultural Relevance Questionnaire (CRQ). Five women with BN and seven clinicians were interviewed using the CRQ.ResultsQuantitative analyses were conducted to assess cultural adaptation of the prototype of the program and participants rated cultural adaptation as high. A qualitative analysis of the mixed method supported the culturally sensitive changes implemented.ConclusionsThe results of this study show that a series of processes can make ICBT programs more culturally adapted.

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Guided internet-based cognitive behavioral therapy for obsessive-compulsive disorder: A multicenter randomized controlled trial in Japan

Cited by 16 publications

References 47 publications

Impact of post-COVID conditions on mental health: a cross-sectional study in Japan and Sweden

Impact of post-COVID conditions on mental health: a cross-sectional study in Japan and Sweden

The effectiveness of exposure and response prevention combined with pharmacotherapy for obsessive-compulsive disorder: A systematic review and meta-analysis

Development of a culturally adaptable internet-based cognitive behavioral therapy for Japanese women with bulimia nervosa

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