Abstract:Acetylcholinesterase (AChE) has been widely used for the detection of organophosphate and carbamate pesticides, due to its high sensitivity and low limit of detection to the presence of pesticides. The homology modeled recombinant Bombyx mori Acetylcholinesterase II (rBm-AChE II) and docking results with multiple pesticides inferred that Y398, located at the bottleneck of the active site gorge, might be important for enzyme sensitivity. Thus, three mutants (Y398G, Y398F, Y398W) were constructed and exhibited d… Show more
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