Guide to the Preparation, Use and Quality Assurance of Blood Components.

Napier,

doi:10.1046/j.1365-3148.1998.00155.x

Cited by 5 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…1 The majority of blood services still only assesses predonation Hb levels as eligibility criterion for donation. [2][3][4][5] As many donors become iron-deficient despite this Hb monitoring, ferritin measurements, combined with donation interval extension or iron supplementation in case of low iron stores, are increasingly implemented in blood services, including Sanquin in the Netherlands. 3,[6][7][8][9] Nonetheless, there is considerable debate about the usefulness of these measures as these interventions have negative effects for blood services such as donor lapse due to lack of comprehension and the costs of testing and iron supplementation.…”

Section: Introductionmentioning

confidence: 99%

Donation‐induced iron depletion is significantly associated with low hemoglobin at subsequent donations

et al. 2021

View full text Add to dashboard Cite

Background: Blood donation is associated with a loss of hemoglobin (Hb)-bound iron. Hb levels recover relatively fast by using stored iron. However, it takes more time to replenish iron stores, potentially resulting in iron deficiency.Study design: Hb and ferritin levels were measured in 5056 new, first-time, and repeat whole blood donors. We investigated whether increasing numbers of donations are associated with lower ferritin levels. Furthermore, we tested whether low ferritin levels are associated with low-Hb deferral at the subsequent donation attempt by performing logistic regression adjusted for age and stratified by sex. Results: Whereas mean Hb levels are relatively stable, ferritin levels significantly decrease with increasing numbers of donations and were approximately 50% lower for donors with >50 donations compared with those with 2-10 donations. Despite the poor correlation of ferritin and Hb levels, cross-sectional, iron-deficient donors (ferritin <15 ng/ml) had 21.8 (8.5-55.6) higher odds in men, 10.1 (6.1-16.5) in premenopausal women, and 11.7 (5.2-26.4) in postmenopausal women for Hb deferral at a subsequent visit.Discussion: To conclude, repeated donations may induce iron deficiency, which corresponds with an over tenfold increased risk of having insufficiently restored Hb levels at a subsequent donation attempt. Longer donation intervals and/or higher dietary or supplemental iron intake are warranted to prevent accumulated iron depletion and subsequent low-Hb deferral in whole blood donors.

show abstract

Section: Introductionmentioning

confidence: 99%

Donation‐induced iron depletion is significantly associated with low hemoglobin at subsequent donations

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Rationale for the choice of the 3 regimens was to ensure that the blood collections would not result in clinically apparent deleterious effects for the dogs. Therefore, the minimum values described in the veterinary literature [5][6][7][8][9][10] (groups 1 and 3) and the maximum values recommended in human standards 3,4 (group 2) were selected. The preference for a percentage of TBV instead of a fixed blood volume of 450 mL allowed for the collection of specific blood volumes from each dog and thus safe use of donors with a wide range of body weights.…”

Section: Methodsmentioning

confidence: 99%

“…Guidelines for human blood banks recommend a maximum of 4 donations/y for men and 3 donations/y for women, with intervals of ≥ 3 months between donations. 3,4 Furthermore, each procedure must result in a depletion of ≤ 13% of TBV. 3,4 Several protocols have been reported in the veterinary literature, with blood collections ranging from 10 to 22 mL/kg (4.5 to 10 mL/lb) every 21 to 28 days without nutritional iron supplementation [5][6][7][8][9] or every 10 to 21 days with nutritional iron supplementation.…”

mentioning

confidence: 99%

“…3,4 Furthermore, each procedure must result in a depletion of ≤ 13% of TBV. 3,4 Several protocols have been reported in the veterinary literature, with blood collections ranging from 10 to 22 mL/kg (4.5 to 10 mL/lb) every 21 to 28 days without nutritional iron supplementation [5][6][7][8][9] or every 10 to 21 days with nutritional iron supplementation. 10 However, the lack of long-term studies of dogs that are frequent blood donors limits knowledge of the cumulative effects of such frequent blood collections.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Effects of repeated blood donations on iron status and hematologic variables of canine blood donors

Ferreira¹,

Gopegui²,

Araujo³

et al. 2014

javma

View full text Add to dashboard Cite

All blood donation regimens induced a bone marrow regenerative response, which was able to restore depleted blood cells within 10 days after blood donation while maintaining iron status within the calculated reference range. However, dogs donating 13% of TBV every 2 months had a significant decrease in iron stores, which suggested that iron-related variables must be monitored during prolonged blood donor programs.

show abstract

“…In compliance with current EU legislation donation by any donor over the age of 65 is subject to annual permission by the blood bank physician. 10 With increasing experience with older donors, we wondered whether donor complication rates in our donor pool justify relaxing the age limit for first-time donors as well. Since the current age limit precludes analysis of complication rates in first-time donors over 65 years old, this leaves us with using repeat donors with advanced age as a proxy.…”

mentioning

confidence: 99%

Donor complication rates in whole blood, plasma and platelet donors: Age versus experience

Paalvast,

Díaz Padilla,

Bruijns

et al. 2024

Transfusion

View full text Add to dashboard Cite

BackgroundMany blood banks use upper age limits for donors out of concern for a higher donor complication rate in older donors. Experienced donors are known to have lower donor complication rates, and older donors are often more experienced, confounding the effect of age on donor complication rate.Study Design and MethodsWe studied donor complication rates in whole blood, plasma, and plateletpheresis donors from 2012 to 2022. Donor complication rates were compared between age groups in inexperienced (<20th donation) and experienced (≥20th donation) donors. In addition to this direct comparison, we made use of logistic regression with finer‐grained experience groups, to further quantify the effects of age, experience and other factors on donor complication rate.ResultsWhile overall rate of vasovagal reaction was lower, rate of moderate/severe vasovagal syncope was highest in 70–79 year donors, however, only reached significance for plasma donors. Furthermore, rates of failed stab were highest in this age group. Hematoma rate showed a U‐shaped pattern with regard to age, where the rate was not higher in the 70–79 year age group than in the 18–23 year age group. Pain decreased with age, however, rates were higher in the 70–79 year age group than in the 65–69 year age group.DiscussionWhen properly accounting for donor experience, donor complication rate profiles clearly change with age. The increased risk for moderate/severe vasovagal syncope in older donors should be clearly communicated. Extra caution is needed if these donors are accepted for first‐time donations.

show abstract

Guide to the Preparation, Use and Quality Assurance of Blood Components.

Cited by 5 publications

References 0 publications

Donation‐induced iron depletion is significantly associated with low hemoglobin at subsequent donations

Donation‐induced iron depletion is significantly associated with low hemoglobin at subsequent donations

Effects of repeated blood donations on iron status and hematologic variables of canine blood donors

Donor complication rates in whole blood, plasma and platelet donors: Age versus experience

Contact Info

Product

Resources

About