Guide for judicious use of the paracetamol absorption technique in a study of gastric emptying rate of liquids

Sanaka, Masaki; Kawakami, Yasushi; Yamanaka, Masami

doi:10.1007/s005350050177

Cited by 57 publications

(69 citation statements)

References 44 publications

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“…make it difficult to interpret and compare all studies with each other (Sanaka et al, 1998). Therefore, because of these drawbacks, other techniques are more preferred to study gastric emptying.…”

Section: Following the Behavior Of Oral Formulations In The Upper Gi mentioning

confidence: 99%

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

Hens

Corsetti

Spiller

et al. 2017

International Journal of Pharmaceutics

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(2017) Exploring gastrointestinal variables affecting drug and formulation behavior: methodologies, challenges and opportunities. International Journal of Pharmaceutics, 519 (1-2). pp. 79-97. ISSN 1873-3476Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/39960/1/FinalVersion-Revised-FOR_EPRINTS_1_YEAR_EMBARGO_ELSEVIER.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the Creative Commons Attribution Non-commercial No Derivatives licence and may be reused according to the conditions of the licence. For more details see: http://creativecommons.org/licenses/by-nc-nd/2.5/ A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. After oral intake, a drug formulation is challenged by several gastrointestinal (GI) barriers. Complex variables such as pH, GI secretions and GI transit/motility along the GI tract can affect drug release and absorption in a positive or negative way depending on the physicochemical properties of the drug compound (e.g. pH/pKa interplay for ionizable drugs) and/or the formulation characteristics (e.g. pHsensitive coating). In addition, inter-subject variability in characteristics of the GI environment may cause variable drug absorption and systemic drug availability (Riethorst et al., 2015). Determining the median and range for specific GI variables, and understanding how they influence oral drug behavior along the GI tract, will be helpful in the field of drug development. 2The present review provides an overview of different methodologies that can be applied to study physiological variables of the human GI tract and their impact on oral drug absorption in healthy and patient populations. The methodologies have been subdivided into two groups: (i) noninvasive and (ii) invasive methodologies. Although some of the methodologies are more historical than operational, they have been of paramount importance for innovations in drug and formulation development; in addition, they have created the basis for several novel methodologies, leading to an in-depth comprehension of different GI variables: gastric emptying (magnetic resonance imaging (MRI), scintigraphy, acetaminophen absorption technique, ultrasonography, breath test, intraluminal sampling and telemetry), motility (MRI, small intestinal/colonic manometry and telemetry), GI volume changes (MRI and ultrasonography), temperature (telemetry) and GI pH (intraluminal sampling and telemetry). Noninvasive methodologiesa. Scintigraphy Disturbances in the normal movement of food along the GI tract can be associated with abdominal pain, early satiety and nausea. Measurement of GI transit, es...

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Section: Following the Behavior Of Oral Formulations In The Upper Gi mentioning

confidence: 99%

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

Hens

Corsetti

Spiller

et al. 2017

International Journal of Pharmaceutics

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show abstract

“…The tracer, the paracetamol absorption approach and the 13 C-octanoate breath test (OBT), all support convenient means of evaluating GET. However, the breath test yields only a convolution index of GE, although it requires no gamma camera and can be performed at the bedside (Sanaka et al, 1998;2006). The use of a gamma camera to survey the absorption by subjects of Tc-99m radionuclidelabeled products satisfies the criteria for the application of the GI tract biokinetic model, because the short physical half life of Tc-99m is such that a limited dose is delivered.…”

Section: Gastrointestinal Tract Modelmentioning

confidence: 99%

Quantitative Analysis of Iodine Thyroid and Gastrointestinal Tract Biokinetic Models Using MATLAB

Hsu¹,

Chen²,

Pan³

2011

Applications of MATLAB in Science and Engineering

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“…Patients in group C in the first 24 hours received only crystalloid solutions and after 24 hours a paracetamol solution (1000 mg/50 ml) was administrated, also via the nasogastric tube. Gastric motility (emptying) measurement The paracetamol absorption model was used as an indirect measure of gastric motility and emptying (7,8). Venous blood samples were obtained via an indwelling peripheral cannula immediately before (calibration sample) and at 15 (t+15), 30 (t+30), 60 (t+60) and 120 (t+120) min after the administration of paracetamol.…”

Section: Enteral Feeding Protocol (6)mentioning

confidence: 99%

Early postoperative gastric enteral nutrition improves gastric emptying after noncomplicated cardiac surgery

Šustić

Zelić

Medved

et al. 2006

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Guide for judicious use of the paracetamol absorption technique in a study of gastric emptying rate of liquids

Cited by 57 publications

References 44 publications

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

Quantitative Analysis of Iodine Thyroid and Gastrointestinal Tract Biokinetic Models Using MATLAB

Early postoperative gastric enteral nutrition improves gastric emptying after noncomplicated cardiac surgery

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