Guidance on Safety/Health for Process Intensification Including MS Design. Part IV: Case Studies

Abstract

The new technology of process intensification by multiscale equipment can significantly contribute to the achievement of a safer design by switching from batch/semi-batch to continuous operation combined with a reduction of the inventory of hazardous substances in critical stages. On the other hand, the shift to higher space-time-yields and temperatures comprises new risks (see Parts I and II). A tool was developed for preliminary risk assessment to cover characteristic features of micro-designed equipment, called HAZOP-LIKE study (see Part III). The generic case studies were applied to two demonstration projects within the IMPULSE project: sulfur dioxide oxidation and the alkylation reaction for the production of ionic liquids. The generic templates proved to be applicable and support comprehensive risk analysis studies on processes with hidden deviations not obviously following traditional HAZOP studies.

Beyond Organometallic Flow Chemistry: The Principles Behind the Use of Continuous-Flow Reactors for Synthesis

“…in catalyst beds, 147 which can serve as an ignition source. [148][149][150][151] Surface effects are also important as they can initiate the decomposition of compounds, e.g. steel reactors can initiate radical formation.…”

Bridging the gap: A nested-pipe reactor for slow reactions in continuous flow chemical synthesis

“…With regard to the operational risks expected from the production of [EMIM]EtSO 4 , a systematic evaluation of the potential hazards was performed in cooperation with a team of industrial experts [10][11][12][13]. In order to minimise potential hazards related to handling of chemicals and operation of the demonstrator facility, a number of preventive design measures were taken (Table 3).…”

Review of Process Industry Accidents Analysis towards Safety System Improvement and Sustainable Process Design

“…Recurrence of accidents in process industries is due to the lack of proper use of accident information , as apparent from recent industrial disasters , . It can be avoided through sustainable process designing at design stage and improving the practices during the operating phase to fulfill the objective of process safety , . Besides, the public awareness regarding process hazards makes it compulsory to do some safety arrangements .…”