Guidance in selecting analytical techniques for identification and quantification of non-intentionally added substances (NIAS) in food contact materials (FCMS)

Nerín, Cristina; Bourdoux, Siméon; Faust, Birgit; Gude, Thomas; Lesueur, Céline; Simat, T. J.; Stoermer, Angela; Hoek, Els Van; Oldring, P. K. T.

doi:10.1080/19440049.2021.2012599

Cited by 47 publications

(26 citation statements)

References 78 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Analytical Methods For the Determination Of Migrants Of Poly...mentioning

confidence: 99%

“…However, despite the powerful analytical techniques that are being used it is not possible to identify all detected compounds. The limited information about the formulation composition and the manufacturing process makes the identification of unknown migrants an extremely difficult task (Nerín et al, 2022;Hoppe et al, 2016;Bradley et al, 2008). 3.1.1 Analysis of bisphenols, BADGEs, and derivatives in epoxy resins High-performance liquid chromatography with fluorescence detection (HPLC-FLD) has proven, since the 90s, to be a sensitive, inexpensive, and valuable technique for the determination of bisphenol-related compounds, BADGEs, and its derivatives from epoxy resins (Paseiro-Losada et al, 1991;Paseiro-Losada et al, 1997;Nerín et al, 2002).…”

Section: Determination Of Migrants In Polymeric Coatingsmentioning

confidence: 99%

“…In addition to intentionally added substances, such as prepolymers, monomers, additives, catalysts, and so on, the final material may also contain the so‐called nonintentionally added substances (NIAS), such as impurities, reaction products, degradation products, and so on. Thus, a large number of substances can be present in the final materials and have the potential to migrate into the foodstuffs (Aznar et al., 2015; Kato & Conte‐Junior, 2021; Nerín et al, 2022). Migration is a mass transfer phenomenon where the substance transferred from the packaging to the food is called migrant.…”

Section: Introductionmentioning

confidence: 99%

“…Liquid chromatography and gas chromatography coupled to mass spectrometry, particularly to high‐resolution mass spectrometry (HRMS), have shown to be powerful tools to accomplish this challenging task (Canellas et al., 2019; Nerín et al, 2013). The strengths and limitations of the analytical techniques used in the analysis of migrants from food contact materials (FCMs) are summarized in a recent review (Nerín et al., 2022).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Food and beverage can coatings: A review on chemical analysis, migration, and risk assessment

Lestido‐Cardama

Sendón

Bustos

et al. 2022

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

The internal surface of food and beverage cans is generally covered with polymeric coatings to preserve food and protect metal substrate from corrosion.Coating materials are complex formulations that contain different starting substances (e.g., monomers, prepolymers, additives, etc.) and in addition during the manufacture of the material several compounds can be formed (e.g., reaction products, degradation products, etc.). These substances have the potential to migrate into the food. Many of them have not been identified and only some have been toxicologically evaluated. This article aims to provide a comprehensive review on the analytical methods used for the identification of potential migrants in can coatings. The migration and exposure to chemicals migrating from can coatings are also reviewed and discussed so far, which is essential for risk assessment. Moreover, a brief section on the current status of the legislation on varnishes and coatings for food contact in Europe is also presented. Liquid chromatography coupled to diode array and fluorescence detectors and particularly to mass spectrometry and gas chromatography-tandem mass spectrometry seem to be the techniques of choice for the identification of potential migrants in can coatings. Some studies have reported migration levels of BPA (bisphenol A) and BADGE (bisphenol A diglycidyl ether) and derivatives exceeding the specific migration limits set in the European legislation. On the whole, low dietary exposure to migrants from can coatings has been reported. However, it is interesting to highlight that in these studies the combined exposure to multiple chemicals has not been considered.

show abstract

Section: Analytical Methods For the Determination Of Migrants Of Poly...mentioning

confidence: 99%

Section: Determination Of Migrants In Polymeric Coatingsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Food and beverage can coatings: A review on chemical analysis, migration, and risk assessment

Lestido‐Cardama

Sendón

Bustos

et al. 2022

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

show abstract

“…Those challenges have been extensively covered by the reviews of Groh & Muncke (2017); Nerín et al. (2022); Peters et al. (2019); Schilter et al.…”

Section: What Is the Current State Of Safety Assessment And Sample Pr...mentioning

confidence: 99%

Current approaches and challenges of sample preparation procedures for the safety assessment of paper and cardboard food contact materials: A comprehensive review

Kourkopoulos

Sijm

Vrolijk

2022

Comp Rev Food Sci Food Safe

View full text Add to dashboard Cite

In the European Union (EU), Regulation (EC) 1935/2004 provides a harmonized legal EU framework and sets out the general principles for safety and inertness for all Food Contact Materials (FCMs) and Food Contact Articles. From a food safety point of view, however, specific EU legislation for paper and cardboard FCMs is lacking, while at Member State level, national legislation differs among countries. More than 11,000 chemicals have been identified in all types of FCMs, most of them without any information on toxicity or migration potential from FCM to food. The present review shows a wide variability of protocols, approaches, and conditions used in scientific studies, which are difficult to compare. In this regard, procedures and conditions laid down in EU legislation for plastics and European Standards (EN protocols) may serve as a good basis for the future sample preparation procedures in the framework of paper and cardboard FCMs safety assessment. Challenges on sample preparation procedures are presented involving the interlinked steps of sample preparation, conditions used and their impact in chemical analysis and in vitro bioassay testing. Currently, there is no general consensus on the criteria for structuring, evaluating, and tuning sample preparation procedures for paper and cardboard FCMs. For this purpose, a set of modified criteria and a decision tree are proposed based on the literature. Along this, mass transfer processes occurring in paper and cardboard FCMs and parameters affecting chemical migration need to be accounted for prior to reaching general consensus on criteria for sample preparation procedures.

show abstract

Circularity of Polymers Used in Hospitals: Current Status, Challenges, and Future Solutions

Zechel,

Schubert

et al. 2024

Advanced Sustainable Systems

View full text Add to dashboard Cite

Polymers are applied extensively in the healthcare sector and enable a variety of different applications. In addition to packaging and personal protective equipment, a large number of medical devices are also coated with or consist of polymers. Today's medicine is therefore inconceivable without these materials. However, the huge challenge is to design these polymers more sustainable and to find new possibilities for the future of medicine with polymers. This study therefore highlights potential ways, in how polymers applied in the healthcare sector and in particular in hospitals can be utilized in a circular manner, but also indicates what risks and challenges this entails.

show abstract

Guidance in selecting analytical techniques for identification and quantification of non-intentionally added substances (NIAS) in food contact materials (FCMS)

Cited by 47 publications

References 78 publications

Food and beverage can coatings: A review on chemical analysis, migration, and risk assessment

Food and beverage can coatings: A review on chemical analysis, migration, and risk assessment

Current approaches and challenges of sample preparation procedures for the safety assessment of paper and cardboard food contact materials: A comprehensive review

Circularity of Polymers Used in Hospitals: Current Status, Challenges, and Future Solutions

Contact Info

Product

Resources

About