Guggulsterone: a Potent Natural Hypolipidemic Agent from Commiphora wightii – Problems, Perseverance, and Prospects

Ramawat, K. G.; Marthur, M.; Dass, Suchismita; Suthar, S.

doi:10.1007/978-3-540-74603-4_5

Cited by 21 publications

(15 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…E and Z guggulsterones have been reported to be 10% [50]. According to Ramawat et al [6], the two isomers E-and Z-guggulsterones are interconvertible in callus and cell cultures.…”

Section: Chemical Composition Of Guggulu or Oleo Gum Resinmentioning

confidence: 99%

“…It is widely distributed in tropical regions of Africa, Madagascar, Asia [4], Australia and Pacific Islands [5]. Six species of this genus are found in Indian sub-continent [5] and three of these (viz., C. wightii, C. agallocha and C. berryi) occur in India [5,6]. Atal et al [7] reported four species from India.…”

Section: The Plant: Commiphora Wightii (Arnott) Bhandarimentioning

confidence: 99%

“…Guggul gum is a mixture of 61% resin, 29.3% gum [40], 6.1% water, 0.6% volatile oil and 3.2% foreign matter [41]. Guggulu, the gum-resin exudate from the tree Commiphora mukul, is a complex mixture of steroids, diterpenoids, aliphatic esters, carbohydrates and a variety of inorganic ions, besides minor amounts of sesamin and other unidentified constituents [42].…”

Section: Chemical Composition Of Guggulu or Oleo Gum Resinmentioning

confidence: 99%

“…From among 185 species of Commiphora, C. wightii is the guggulsterone producing species, therefore, it becomes essential to develop a high throughput method for production of guggulsterone in vitro [2,87]. According to Ramawat et al [6] and Suri and Ramawat [88], the cytodifferentiation in callus and cell cultures is primary prerequisite for production of secondary metabolites which are produced in complex tissue systems like laticifers or resin canals. Kumar et al [89] reported the formation of resin canals but the slow growth of cultures was a limitation.…”

Section: Guggulsterone Production Through Cell Culturementioning

confidence: 99%

See 3 more Smart Citations

<i>Commiphora wightii</i> (Arnott) Bhandari—A Natural Source of Guggulsterone: Facing a High Risk of Extinction in Its Natural Habitat

Jain¹,

Nadgauda²

2013

AJPS

View full text Add to dashboard Cite

The plants are the primary producers and an indispensible source of food and nutrition, medicine and fuel/biofuel. Unsustainable overharvesting and indiscriminate felling of plants due to ever increasing needs of population pressure are causes of great concern. The IUCN includes, the species facing a high risk of extinction in the wild as threatened, and "endangered" is one of the sub-categories under "threatened" category. Commiphora wightii (Arnott) Bhandari is an arid region plant, highly valued for its medicinally important guggul gum-resin as a source of guggulsterone. It is listed in IUCN's Red Data List of threatened plants and now it is becoming endangered. Its population is fast depleting in its natural habitat, primarily due to over-exploitation, unsustainable and destructive methods of gum-extraction coupled with natural dry-arid habitat, slow growth and poor regeneration of the plant. Several other reasons have also been indicated for its declining population. Therefore, it demands severe measures for its conservation before we completely lose this important medicinal plant. A lot of research and study is underway but has vast scope for improvement, requiring efforts to supplement with such information that would aid transgenic development and breeding programmes for production and cultivation of improved varieties. The article presents the importance of this plant and its conservation in a nut-shell.

show abstract

“…E and Z guggulsterones have been reported to be 10% [50]. According to Ramawat et al [6], the two isomers E-and Z-guggulsterones are interconvertible in callus and cell cultures.…”

Section: Chemical Composition Of Guggulu or Oleo Gum Resinmentioning

confidence: 99%

Section: The Plant: Commiphora Wightii (Arnott) Bhandarimentioning

confidence: 99%

Section: Chemical Composition Of Guggulu or Oleo Gum Resinmentioning

confidence: 99%

Section: Guggulsterone Production Through Cell Culturementioning

confidence: 99%

See 2 more Smart Citations

<i>Commiphora wightii</i> (Arnott) Bhandari—A Natural Source of Guggulsterone: Facing a High Risk of Extinction in Its Natural Habitat

Jain¹,

Nadgauda²

2013

AJPS

View full text Add to dashboard Cite

show abstract

“…and Sushruta (600 B.C). Vagbhata (1700 A.D.) has described the use of guggul as a drug of choice for medoroga and vatavikaras [16][17][18][19] . Some plants and crude drugs obtained from the plant are generally possessed unwanted impurities and toxic substances, which can lead to harmful effect to human body 20 like Aconite, Nux vomica, Bhillama, Abrus, Datura, etc., these toxic substances should be removed from the raw drugs.…”

mentioning

confidence: 99%

Qualitative and Quantitative Estimation of Guggulsterone E and Z in Different Sodhit Guggul by LC-MS and HPLC Method

Mayuree

Carol

Suhagia

et al. 2017

Journal of Natural Remedies

View full text Add to dashboard Cite

Pharmacological Properties of Guggulsterones, the Major Active Components of Gum Guggul

Shah

Gulati

Palombo

2012

Phytotherapy Research

View full text Add to dashboard Cite

Oleo gum resin secreted by Commiphora mukul, also known as gum guggul, has been used widely as an ayurvedic drug. Commiphora mukul is a short thorny shrub that is native to the Indian subcontinent. Oleo gum resin extracted by incision of the bark is a very complex mixture of gum, minerals, essential oils, terpenes, sterols, ferrulates, flavanones and sterones. Its active constituents, the Z- and E-guggulsterones, have been demonstrated to exhibit their biological activities by binding to nuclear receptors and modulating the expression of proteins involved in carcinogenic activities. Guggulsterones have also been reported to regulate gene expression by exhibiting control over other molecular targets including transcription factors such as nuclear factor (NF)-κB, signal transducer and activator of transcription (STAT) and steroid receptors. Considerable scientific evidence indicates the use of gum guggul as a therapeutic agent in the treatment of inflammation, nervous disorders, hyperlipidaemia and associated cardiac disorders such as hypertension and ischaemia, skin disorders, cancer and urinary disorders. This review highlights the taxonomic details, phytochemical properties and pharmacological profile of gum guggul.

show abstract

Guggulsterone: a Potent Natural Hypolipidemic Agent from Commiphora wightii – Problems, Perseverance, and Prospects

Cited by 21 publications

References 57 publications

<i>Commiphora wightii</i> (Arnott) Bhandari—A Natural Source of Guggulsterone: Facing a High Risk of Extinction in Its Natural Habitat

<i>Commiphora wightii</i> (Arnott) Bhandari—A Natural Source of Guggulsterone: Facing a High Risk of Extinction in Its Natural Habitat

Qualitative and Quantitative Estimation of Guggulsterone E and Z in Different Sodhit Guggul by LC-MS and HPLC Method

Pharmacological Properties of Guggulsterones, the Major Active Components of Gum Guggul

Contact Info

Product

Resources

About

Guggulsterone: a Potent Natural Hypolipidemic Agent from Commiphora wightii – Problems, Perseverance, and Prospects

Cited by 21 publications

References 57 publications

&lt;i&gt;Commiphora wightii&lt;/i&gt; (Arnott) Bhandari—A Natural Source of Guggulsterone: Facing a High Risk of Extinction in Its Natural Habitat

&lt;i&gt;Commiphora wightii&lt;/i&gt; (Arnott) Bhandari—A Natural Source of Guggulsterone: Facing a High Risk of Extinction in Its Natural Habitat

Qualitative and Quantitative Estimation of Guggulsterone E and Z in Different Sodhit Guggul by LC-MS and HPLC Method

Pharmacological Properties of Guggulsterones, the Major Active Components of Gum Guggul

Contact Info

Product

Resources

About

<i>Commiphora wightii</i> (Arnott) Bhandari—A Natural Source of Guggulsterone: Facing a High Risk of Extinction in Its Natural Habitat

<i>Commiphora wightii</i> (Arnott) Bhandari—A Natural Source of Guggulsterone: Facing a High Risk of Extinction in Its Natural Habitat