Guest‐Release Control in Enzyme‐Sensitive, Amphiphilic‐Dendrimer‐Based Nanoparticles through Photochemical Crosslinking

Raghupathi, Krishna R.; Azagarsamy, Malar A.; Thayumanavan, S.

doi:10.1002/chem.201101066

Cited by 62 publications

(64 citation statements)

References 79 publications

(29 reference statements)

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“…Our group introduced coumarin into dendrimers as a reversible cross-linker to control the accessibility of substrate in the dendrimer assembly (see Figure 28) [66]. When the assembly solution was exposed to UV light (365 nm), the enzymatic degradation of substrate was highly suppressed since the ester groups were confined in the interior of assembly.…”

Section: Methods Of Synthesis Of Nanogelsmentioning

confidence: 99%

Polymer nanogels: A versatile nanoscopic drug delivery platform

Chacko

Ventura

Zhuang

et al. 2012

Advanced Drug Delivery Reviews

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559

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In this review we put the spotlight on crosslinked polymer nanogels, a promising platform that has the characteristics of an “ideal” drug delivery vehicle. Some of the key aspects of drug delivery vehicle design like stability, response to biologically relevant stimuli, passive targeting, active targeting, toxicity and ease of synthesis are discussed. We discuss several delivery systems in this light and highlight some examples of systems, which satisfy some or all of these design requirements. In particular, we point to the advantages that crosslinked polymeric systems bring to drug delivery. We review some of the synthetic methods of nanogel synthesis and conclude with the diverse applications in drug delivery where nanogels have been fruitfully employed.

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Section: Methods Of Synthesis Of Nanogelsmentioning

confidence: 99%

Polymer nanogels: A versatile nanoscopic drug delivery platform

Chacko

Ventura

Zhuang

et al. 2012

Advanced Drug Delivery Reviews

Self Cite

559

382

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show abstract

“…116 In this case, we monitored enzymatic cleavage reaction using the release of a covalently conjugated fluorophore, 4-methylumbelliferone (MUF) (Fig.20). Concurrent monitoring of MUF fluorescence and that of a non-covalently encapsulated fluorophore suggested that there is a clear correlation between the kinetics of the enzymatic reaction and that of the guest molecule release.…”

Section: Stimuli Responsive Dendrimersmentioning

confidence: 99%

Experimental and theoretical investigations in stimuli responsive dendrimer-based assemblies

et al. 2015

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Stimuli-responsive macromolecular assemblies are of great interest in drug delivery applications, as it holds the promise to keep the drug molecules sequestered under one set of conditions and release them under another. The former set of conditions could represent circulation, while the latter could represent a disease location. Over the past two decades, sizeable contributions to this field have come from dendrimers, which along with their monodispersity, provide great scope for structural modifications at the molecular level. In this paper, we briefly discuss the various synthetic strategies that have been developed so far to obtain a range of functional dendrimers. We then discuss the design strategies utilized to introduce stimuli responsive elements within the dendritic architecture. The stimuli itself are broadly classified into two categories, viz. extrinsic and intrinsic. Extrinsic stimuli are externally induced such as temperature and light variations, while intrinsic stimuli involve physiological aberrations such as variations in pH, redox conditions, proteins and enzyme concentrations in pathological tissues. Furthermore, the unique support from molecular dynamics (MD) simulations has been highlighted. MD simulations have helped back many of the observations made from assembly formation properties to rationalized the mechanism of drug release and this has been illustrated with discussions on G4 PPI (Poly propylene imine) dendrimers and biaryl facially amphiphilic dendrimers. The synergy that exists between experimental and theoretical studies open new avenues for the use of dendrimers as versatile drug delivery systems.

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“…Here, we have also found that monomer-aggregate equilibrium plays an important role on the enzymatic cleavage and the ensued guest molecule release. 86 Currently studies are underway in our laboratory to discern alternate pathways, if any, involved to affect the non-covalent guest molecule release from these nanocontainers.…”

Section: Protein Sensitive Amphiphilic Dendrimersmentioning

confidence: 99%

Stimuli sensitive amphiphilic dendrimers

et al. 2012

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In the past decade, there has been an increasing interest in supramolecular systems that can undergo physical or chemical tranformations upon encountering a specific stimulus. Micelle-forming amphiphilic systems based on polymers and dendrimers are particularly preferred over small molecule amphiphiles, due to their ability to sequester and release a vast library of hydrophobic guest molecules at micromolar polymer or dendrimer concentrations. Here we review a relatively underexplored, yet rapidly advancing, field of amphiphilic systems based on dendritic architechture that exhibit stimuli sensitive behaviour. In particular, we will be focusing on stimuli such as temperature, pH, enzymatic and non-enzymatic proteins. These stimuli-responsive systems offer a unique opportunity in the field of drug delivery and sensing.

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Guest‐Release Control in Enzyme‐Sensitive, Amphiphilic‐Dendrimer‐Based Nanoparticles through Photochemical Crosslinking

Cited by 62 publications

References 79 publications

Polymer nanogels: A versatile nanoscopic drug delivery platform

Polymer nanogels: A versatile nanoscopic drug delivery platform

Experimental and theoretical investigations in stimuli responsive dendrimer-based assemblies

Stimuli sensitive amphiphilic dendrimers

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