Guduchi Ghanavati (Ayurveda medication) improves the perceived immunity in individuals at risk of SARS-CoV-2: A multicentred, controlled, before-and-after study

Thakar, Anup B; Panara, Kalpesh; Shah, Harshit; Kalsariya, Bharat; Ruparel, Sweety; Jain, Neha; Bhatt, Parthiv; Jani, Dilip; Dodia, Rajendrasinh; Patel, Falgun; Salve, Rohan Suryakant; Chaudhari, Swapnil; Raghavani, Hemang Umedbhai; Vyas, Jatin M.; Goyal, Mandip; Bhinde, Sagar

doi:10.1016/j.eujim.2022.102131

Cited by 10 publications

(4 citation statements)

References 16 publications

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“…• Curcumin suppresses acute as well as chronic inflammation by lowering histamine levels, increasing cortisone production, suppressing NFkB-dependent cytokine production and preventing platelet-derived growth factor (PDGF). (Rahmani et al, 2018) (Continues) reported that when Guduchi Ghanavati was prescribed for the prevention and management of COVID-19, it was found to be safe and improved immune status in individuals at risk of developing SRAS-CoV-2 (Thakar, Panara, Shah, et al, 2022).…”

Section: Giloy (Tinospora Cordifolia)mentioning

confidence: 99%

“…Another multicenter, controlled, quasi-experimental clinical trial was conducted in India on Giloy Ghan Vati in individuals at moderate to very high risk of SARS-COV-2 exposure and it was observed that Giloy Ghan Vati was safe and improves perception of immune status in individuals at risk of developing SRAS-CoV-2. However, these findings are inadequate to establish that Giloy Ghan Vati lowers the incidence of COVID-19 (Thakar, Panara, Shah et al, 2022). In another clinical trial, where honey and Nigella sativa was given along with standard care, it was observed that this treatment improves symptoms, expedites viral clearance, and reduces mortality in COVID-19 patients (Ashraf et al, 2023).…”

Section: Modulation Of Sars-cov-2 Pathogenesis By Ayurvedic Kwathmentioning

confidence: 99%

“…In a recent pilot study, the formulation of Tinospora cordifolia ( Giloy ) and Piper longum (Pippali ) reduced the length of hospital stay and improve the recovery time (Kataria et al, 2021). In another study, Thakar et al reported that when Guduchi Ghanavati was prescribed for the prevention and management of COVID‐19, it was found to be safe and improved immune status in individuals at risk of developing SRAS‐CoV‐2 (Thakar, Panara, Shah, et al, 2022).…”

Section: Pharmacology Of Different Herbs and Spices Used In Kwath Pre...mentioning

confidence: 99%

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Culinary spices and herbs in managing early and long‐COVID‐19 complications: A comprehensive review

Sharma

2023

Phytotherapy Research

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Human race is preparing for the upsurge and aftermath of COVID‐19 pandemic complicated by novel variants, new waves, variable mortality rate, and post‐COVID complications. Despite use of repurposed drugs, symptomatic treatments and licensing of multiple vaccines, the daily number of cases and rate of transmission are significant. Culinary spices and herbs have been historically used in pandemic and non‐pandemic times to reduce respiratory viral burden. Specific food items and culinary spices can boost the levels of protective immunity and also offer therapeutic benefits against impervious bugs via well‐known as well as less‐known but scientifically testable mechanisms. Here, we analyzed the phytochemicals profile of Ayurvedic herbs and inferred from the clinical trials/observational studies to provide a focused and succinct perspective on the relevance of “food‐based” traditional decoction to moderate COVID‐19 disease and long‐COVID via modulation of immunity and reinstatement of homeostasis. We also underscore the druggable targets in pathogenesis of COVID‐19 which are relevant to the ongoing clinical trials using spices and herbs. This information will provide a strong scientific rationale for standardization of the traditional herbs‐based therapies and adopting the use of herbs, spices, and their formulations for reducing SARS‐CoV‐2 transmission, long‐COVID symptoms, and COVID‐19 disease progression.

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Section: Giloy (Tinospora Cordifolia)mentioning

confidence: 99%

Section: Modulation Of Sars-cov-2 Pathogenesis By Ayurvedic Kwathmentioning

confidence: 99%

Section: Pharmacology Of Different Herbs and Spices Used In Kwath Pre...mentioning

confidence: 99%

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Culinary spices and herbs in managing early and long‐COVID‐19 complications: A comprehensive review

Sharma

2023

Phytotherapy Research

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“…[68] As a preventive and prophylactic medicine for COVID-19, it is advised to take 500 mg of Guduchi ghana vati, also known as Sanshamani Vati, which is a supplement that includes an aqueous extract of T. cordifolia. [69] C. domestica, sometimes known as turmeric, is a common culinary spice in India. The major component purified from the rhizome is curcumin, a polyphenolic molecule.…”

Section: Immunomodulatory Activities Of Some Herbal Drugsmentioning

confidence: 99%

Herbal medicines utilized in the management of COVID-19

Adhikari,

Rangra

2023

Pharmaspire

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COVID-19 management is becoming a popular topic of research among drug developers, researchers, and scientists because the coronavirus is a rapidly dividing virus that spreads by injecting its genome into the genes of other organisms and multiplying there. As a result, it depends on other organisms for its growth which makes it more challenging to eradicate the disease-causing agent. The Coronaviridae family of viruses includes the enveloped, positive-sense single-stranded RNA virus known as coronaviruses (CoV). Different species of the CoV family cause infections of the upper respiratory tract and gastrointestinal tract in mammals and birds. People typically get the common cold from it, but it can also result in complications such as pneumonia and SARS. The more well-known severe acute respiratory syndrome coronavirus, which in 2003 posed a serious threat with a high mortality rate, is one of the recognized human coronaviruses (HCoV), along with HCoV-229E, -OC43, -NL63, -HKU1, and others. The Middle East respiratory syndrome CoV, a sixth kind of HCoV infection with a high mortality rate, was described by the World Health Organization in 2012. Numerous herbal extracts have been used to treat clinical indications related to the respiratory system as ayurvedic medicine has a treatment for a wide variety of illnesses and complex medical diseases. Therefore, a variety of herbal remedies and purely natural substances can greatly help in the creation of novel antiviral treatments. Tinospora cordifolia, Curcuma longa, Ocimum basilicum, and Allium sativum are a few herbs utilized in COVID-19. In this work, an effort has been made to assess problems and potential treatment with the help of herbal medicine.

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Traditional Herbal Medicines and Their Active Constituents in Combating SARS-CoV-2 Infection

Shivangani,

Lakshmi,

Jamir

et al. 2023

Ethnopharmacology and Drug Discovery for COVID-19: Anti-Sars-CoV-2 Agents From Herbal Medicines and Natural Products

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Guduchi Ghanavati (Ayurveda medication) improves the perceived immunity in individuals at risk of SARS-CoV-2: A multicentred, controlled, before-and-after study

Cited by 10 publications

References 16 publications

Culinary spices and herbs in managing early and long‐COVID‐19 complications: A comprehensive review

Culinary spices and herbs in managing early and long‐COVID‐19 complications: A comprehensive review

Herbal medicines utilized in the management of COVID-19

Traditional Herbal Medicines and Their Active Constituents in Combating SARS-CoV-2 Infection

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