Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts
Valeria Rudman-Melnick,
Davy Vanhoutte,
Kaitlynn Stowers
et al.
Abstract:Fibrosis is a common outcome of numerous pathologies, including chronic kidney disease (CKD), a progressive renal function deterioration. Current approaches to target activated fibroblasts, key effector contributors to fibrotic tissue remodeling, lack specificity. Here, we report Gucy1α1 as a specific kidney fibroblast marker. Gucy1α1 levels significantly increased over the course of two clinically relevant murine CKD models and directly correlated with established fibrosis markers. Immunofluorescent (IF) imag… Show more
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