Guava leaf extracts promote glucose metabolism in SHRSP.Z-Leprfa/Izm rats by improving insulin resistance in skeletal muscle

Abstract

BackgroundMetabolic syndrome (MS) and type 2 diabetes mellitus (T2DM) have been associated with insulin-resistance; however, the effective therapies in improving insulin sensitivity are limited. This study is aimed at investigating the effect of Guava Leaf (GL) extracts on glucose tolerance and insulin resistance in SHRSP.Z-Leprfa/Izm rats (SHRSP/ZF), a model of spontaneously metabolic syndrome.MethodsMale rats at 7 weeks of age were administered with vehicle water or treated by gavage with 2 g/kg GL extracts daily for six weeks, and their body weights, water and food consumption, glucose tolerance, and insulin resistance were measured.ResultsCompared with the controls, treatment with GL extracts did not modulate the amounts of water and food consumption, but significantly reduced the body weights at six weeks post treatment. Treatment with GL extracts did not alter the levels of fasting plasma glucose and insulin, but significantly reduced the levels of plasma glucose at 60 and 120 min post glucose challenge, also reduced the values of AUC and quantitative insulin sensitivity check index (QUICKI) at 42 days post treatment. Furthermore, treatment with GL extracts promoted IRS-1, AKT, PI3Kp85 expression, then IRS-1, AMKP, and AKT308, but not AKT473, phosphorylation, accompanied by increasing the ratios of membrane to total Glut 4 expression and adiponectin receptor 1 transcription in the skeletal muscles.ConclusionsThese data indicated that GL extracts improved glucose metabolism and insulin sensitivity in the skeletal muscles of rats by modulating the insulin-related signaling.

Phytopharmacological overview of Psidium guajava Linn.

“…76 Treatment with P. guajava leaf extracts promoted the expression of IRS-1, AKT, PI3Kp85 and IRS-1, AMKP, and AKT308, phosphorylation, accompanied by increasing the ratios of the membrane to the total expression of glucose transporter 4 and adiponectin receptor 1 transcription in the skeletal muscles. 77 These supports the modulating effect of P. guajava leaf extracts in insulin-related signaling. The poly formulation of Anacardium occidentale, Eucalyptus globulus, P. guajava, and Xylopia aethiopica extracts yielded significant result as well as reduces some other complications associated with diabetes in alloxaninduced diabetic models.…”

Caulerpa lentillifera extract ameliorates insulin resistance and regulates glucose metabolism in C57BL/KsJ-db/db mice via PI3K/AKT signaling pathway in myocytes

“…An ideal anti-diabetic drug would improve glucose metabolism and insulin resistance in diabetic patients without causing any side effect. However, currently available anti-diabetic drugs are associated with side effects in long-term use [ 7 ]. In the search for safe and effective natural remedies against diabetes, we previously found the effect of CLE on glucose uptake in adipocytes [ 13 ].…”

“…Thus, the PI3K/AKT and AMPK pathways may be potential targets for the regulation of glucose metabolism in type 2 diabetes and obesity associated with insulin resistance. Guo et al reported that natural products enhance glucose uptake and decrease insulin resistance by the activation of PI3K/AKT or AMPK in diabetic models [ 7 ]. Therefore, interest in the possible therapeutic use of natural products for diabetes has been growing because of the fewer adverse effects comparing to synthetic drugs.…”

Fumigant Activity of thePsidium guajavaVar. Pomifera (Myrtaceae) Essential Oil inDrosophila melanogasterby Means of Oxidative Stress

“…Extracts from leaves and fruits of this species presented several pharmacological properties as antispasmodic, antimicrobial and anti-inflammatory [ 10 ]. Moreover, these extracts also have been used as hypoglycemic [ 11 ]. Despite the available reports on benefits of guava to human health, little is known about its potential in biotechnological applications (e.g., fumigant activity) of guava extracts, oils, and derived compounds.…”