Guardian of Genetic Messenger-RNA-Binding Proteins

Anji, Antje

doi:10.3390/biom6010004

Cited by 14 publications

(9 citation statements)

References 121 publications

(157 reference statements)

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“…It has been established that the stability of mRNAs could be enhanced or weakened by RBPs [19]. Thus, we explored whether LDHB mRNA could be stabilized by a specific RBP.…”

Section: Fus Promotes the Stability Of Ldhb Mrna In Os Cellsmentioning

confidence: 99%

MiR-141-3p overexpression suppresses the malignancy of osteosarcoma by targeting FUS to degrade LDHB

Wang

2020

Bioscience Reports

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Osteosarcoma (OS) is a common malignant bone cancer. Lactate dehydrogenase B (LDHB) has been revealed to act as a tumor promoter in several cancers. It is also revealed to be correlated with poor prognosis in OS, but its molecular mechanism in OS remains veiled. Our work illustrated that LDHB was overexpressed in OS tissues and cells, and it could enhance cell proliferation, migration, and invasion in OS. Subsequently, it was confirmed that fused in sarcoma (FUS) could bind with LDHB to positively regulate the stability of LDHB messenger RNA (mRNA). Besides, FUS expression was revealed to be elevated in OS tissues and positively correlate with LDHB expression. Furthermore, miR-141-3p, down-regulated in OS cells, was identified as the upstream regulator of FUS in OS cells. Besides, miR-141-3p overexpression decreased mRNA and protein levels of FUS and LDHB. More importantly, overexpression of miR-141-3p could impair FUS overexpression-mediated promotion on LDHB mRNA stability and expression. Finally, rescue assays indicated that miR-141-3p regulated OS cells cellular process via regulating LDHB. In sum, miR-141-3p targets FUS to degrade LDHB, thereby attenuating the malignancy of OS cells.

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“…It has been established that the stability of mRNAs could be enhanced or weakened by RBPs [19]. Thus, we explored whether LDHB mRNA could be stabilized by a specific RBP.…”

Section: Fus Promotes the Stability Of Ldhb Mrna In Os Cellsmentioning

confidence: 99%

MiR-141-3p overexpression suppresses the malignancy of osteosarcoma by targeting FUS to degrade LDHB

Wang

2020

Bioscience Reports

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“…It probably is the site bound or activated by the signalling molecular such as methenylTHF in folate metabolism pathway. When bound or activated, MTHFSD specifically regulate all aspects of MTHFS mRNA metabolism including splicing, export from the nucleus, RNA localisation, mRNA turn‐over as well as translation (Anji & Kumari, ). The MTHFSD mRNA has been confirmed to be present in ovary of human with a high expression level especially in GTEx dataset (http://www.proteinatlas.org/ENSG00000103248-MTHFSD/tissue).…”

Section: Discussionmentioning

confidence: 99%

Copy number variations of MTHFSD gene across pig breeds and its association with litter size traits in Chinese indigenous Xiang pig

Ran

Hua

Huang

et al. 2018

Animal Physiology Nutrition

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Copy number variation (CNV) is a major proportion of genetic variation, which changes the gene structure and dosage and affects gene expression and function. To validate the presence and the function of CNV in pig, we used real-time quantitative polymerase chain reaction (qPCR) method to validate a 496 kb CNV region comprising MTHFSD gene on chromosome 6 of Xiang pig detected by single nucleotide polymorphism (SNP) array. Then we investigated the distribution of the MTHFSD CNV in a total of 545 pigs in four breeds. About 46.2% and 32.7% individuals in the four pig breeds were detected to be types of loss and gain of MTHFSD locus. The relative copy numbers of MTHFSD gene showed the largest variation range (0-55 copies) in the Xiang pig population. The copy numbers of MTHFSD gene presented the positive correlations with the transcript level of MTHFSD gene in adult ovaries. Statistical analysis indicated that CNVs of MTHFSD gene was significantly changed the litter size traits of Xiang pigs, and the individuals with CNV gain showed more litter size than the CNV loss pigs. We have reasons to believe that the MTHFSD as RNA-binding protein play an important role in pig reproduction as a result of regulating MTHFS mRNA metabolism.

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“…In this regard, the paper by Natarajan et al [ 1 ] discusses the role of microRNAs in the pathogenesis of alcohol-induced pancreatitis, liver damage, cardiomyopathy, muscle damage, intestinal epithelial barrier dysfunction and brain damage, particularly the altered hippocampus structure and function and neuronal loss. The review by Anji and Kumari [ 2 ] focusses on the effect of alcohol on different RNA-binding proteins and their possible contribution to alcohol-related disorders. The authors present a thoughtful deliberation on the role of these proteins in the development of neurological diseases and cancer as well as the conventional methods and newer techniques that are employed to identify RNA-binding proteins.…”

mentioning

confidence: 99%

“…The list of articles published in Special Issue “Multi-Organ Alcohol-Related Damage: Mechanisms and Treatment” is presented in Refs. [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ].…”

mentioning

confidence: 99%