Guar Gum and Its Pharmaceutical and Biomedical Applications

Manjunath, M.; Anjali, .; Gowda, D. V.; Kumar, Praveen; Srivastava, Atul K.; Osmani, Riyaz Ali M.; Shinde, C. S.; Siddaramaiah,

doi:10.1166/asem.2016.1874

Cited by 20 publications

(5 citation statements)

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“…As the degree of disorder rises in the transition from an ordered solid to a disorganized liquid structure, this is always positive. Fusion is a first-order phase change that occurs at a constant temperature [ 40 ]. Equations (7) and (8) were used to calculate the entropy of fusion (∆S).…”

Section: Resultsmentioning

confidence: 99%

Determination of Temperature-Dependent Coefficients of Viscosity and Surface Tension of Tamarind Seeds (Tamarindus indica L.) Polymer

et al. 2021

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The rheological properties of tamarind seed polymer are characterized for its possible commercialization in the food and pharmaceutical industry. Seed polymer was extracted using water as a solvent and ethyl alcohol as a precipitating agent. The temperature’s effect on the rheological behavior of the polymeric solution was studied. In addition to this, the temperature coefficient, viscosity, surface tension, activation energy, Gibbs free energy, Reynolds number, and entropy of fusion were calculated by using the Arrhenius, Gibbs–Helmholtz, Frenkel–Eyring, and Eotvos equations, respectively. The activation energy of the gum was found to be 20.46 ± 1.06 kJ/mol. Changes in entropy and enthalpy were found to be 23.66 ± 0.97 and −0.10 ± 0.01 kJ/mol, respectively. The calculated amount of entropy of fusion was found to be 0.88 kJ/mol. A considerable decrease in apparent viscosity and surface tension was produced when the temperature was raised. The present study concludes that the tamarind seed polymer solution is less sensitive to temperature change in comparison to Albzia lebbac gum, Ficus glumosa gum and A. marcocarpa gum. This study also concludes that the attainment of the transition state of viscous flow for tamarind seed gum is accompanied by bond breaking. The excellent physicochemical properties of tamarind seed polymers make them promising excipients for future drug formulation and make their application in the food and cosmetics industry possible.

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Section: Resultsmentioning

confidence: 99%

Determination of Temperature-Dependent Coefficients of Viscosity and Surface Tension of Tamarind Seeds (Tamarindus indica L.) Polymer

et al. 2021

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“…It contains nutritional polysaccharides and has numerous benefits; it increases viscosity effectively, provides smooth skin feel and has characteristic high level of lubricity, has favorable film-forming properties, helps stabilize emulsions and has excellent salt and alcohol tolerance in aqueous solutions and can be used for gel products that can be pumped or sprayed (34). The effects of artificial tears based on hydroxypropyl guar recommendations are that it temporarily relieves the sensation of burning and irritation, due to dry eyes, power of action, intensive care; re-wetting of contact lenses made of silicone and soft hydrogel, is hydrophilic, in case of minor irritations, discomfort or blurred vision (35).…”

Section: Methodsmentioning

confidence: 99%

Comparative antioxidant activity of various ophthalmic product types for artificial tears under different experimental conditions

et al. 2022

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Artificial tears or lubricants is a developing category in pharmaceutical research, due to the permanent increasing incidence of dry eye syndrome caused by the extensive use of personal computers and other gadget screens, associated with global warming and pollution. Considering the role of inflammation in dry eye syndrome, characterized by the production of free radicals, it is imperative to determine which elements are more significant in forming an artificial tear more effectively and more comfortably for the eye state and for the quality of life. Thus, the aim of the present study was to examine the evolution of the total antioxidant capacity of some frequently commercialized artificial tears via the photochemiluminescence method, using an antioxidant capacity of lipid soluble substances procedure, prior and subsequent to the exposure of these therapy agents to some physical agents. This is a preliminary research aiming to evaluate the impact of various environmental factors on these ophthalmic products, to be continued by evaluating whether the effectiveness of these products, in terms of objective examination and patient preference and adherence criteria, is impacted by the conditions of use and storage. Thus, the total antioxidant capacity of the evaluated artificial tear samples after UVC irradiation at 254 nm wavelength was studied, in order to investigate whether their status suffered any change in terms of antioxidant potential. In addition to the findings obtained in the study, some recommendations were also made.

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“…Both synthetic and natural polymers can have their own properties that can be useful. But by mixing or combining them, new polymeric materials can be made that are both biocompatible and biodegradable, but also have the best drug release control properties [19]. Several studies have reported the prolonged drug release properties of natural polymer and HPMC blending [20][21][22][23].…”

Section: Swelling Indexmentioning

confidence: 99%

Experimental Design Approach to Fabricate and Optimize Floating Tablets of Levofloxacin for Helicobacter Pylori Infection

et al. 2022

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Objective: To improve the treatment of H. pylori infection, by achieving the required bactericidal concentrations of antibiotics in the stomach, by delivering the antibiotics to the mucus layer and release the drug at the site of infection for a prolonged period would be significantly more effective than conventional dosage forms. Methods: The experimental method of the research was designed to prepare Levofloxacin floating by using Hydroxypropyl Methylcellulose (HPMC K4M), Hydroxypropyl Methylcellulose (HPMC K100M) and Xanthan gum by Three-level Box–Behnken design optimization method. The prepared tablets were evaluated for Thickness, Hardness, Friability, Weight variation, Swelling index (SI), Floating lag time (FLT) and Time required to release 90% of the drug from the tablet (T90%). Results: It was found that the Thickness-3.12±0.11 mm to 3.28±0.10 mm, Hardness-4.52±0.36 kg/cm2 to 4.81±0.24 kg/cm2, Friability-0.81±0.02g to 0.86±0.12g, Weight variation-480±1.90 mg to 523±0.89 mg, Swelling index (SI)-61.9±0.624% to 99.95±0.226%, Floating lag time (FLT)-81.12±0.63 s to 119.7±0.567 s and Time required to release 90% of the drug from the tablet (T90%)-7.0±0.55 h to 10.33±0.289 h. HPMC K100M and Xanthan gum showed good swelling as compared to HPMC K4M. The study revealed that HPMC K100M grade had a significant effect on drug release. Conclusion: The developed gastro-floating tablets can extend levofloxacin duration in the stomach and produce a prolonged release effect. The prepared levofloxacin floating tablet oral drug delivery system appears to be a promising choice for the efficient eradication of H. pylori

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Guar Gum and Its Pharmaceutical and Biomedical Applications

Cited by 20 publications

References 0 publications

Determination of Temperature-Dependent Coefficients of Viscosity and Surface Tension of Tamarind Seeds (Tamarindus indica L.) Polymer

Determination of Temperature-Dependent Coefficients of Viscosity and Surface Tension of Tamarind Seeds (Tamarindus indica L.) Polymer

Comparative antioxidant activity of various ophthalmic product types for artificial tears under different experimental conditions

Experimental Design Approach to Fabricate and Optimize Floating Tablets of Levofloxacin for Helicobacter Pylori Infection

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