2016
DOI: 10.1152/ajpheart.00326.2016
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Guanylyl cyclase can't stand the HETE

Abstract: NITRIC OXIDE (NO)-sensitive isoforms of heterodimeric guanylyl cyclase [␣ 1 ␤ 1 -and ␣ 2 ␤ 1 -soluble guanylyl cyclases (sGC)], extend an umbrella of protection throughout the cardiovascular system, with wide-ranging effects on local blood flow, platelet and leukocyte reactivity, vessel morphology, and cardiac structure and function (5, 10). Consequently, dysfunctional sGC signaling precipitates cardiovascular disease in an analogous manner to deficits in NO bioactivity, perhaps illustrated most tangibly in th… Show more

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