Guanylate Cyclase, a Cell Surface Receptor

Garbers, D L

doi:10.1016/s0021-9258(18)60495-8

Cited by 142 publications

(7 citation statements)

References 78 publications

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“…In addition to its natriuretic, diuretic, and vasorelaxant activities, ANP inhibits the release of aldosterone, renin, and AVP while stimulating the release of androgen, progesterone, and GH. ANP selectively activates particulate guanylate cyclase and inhibits adenylate cyclase, thereby increasing the intracellular accumulation of cGMP and decreasing cAMP (802). The biological actions of ANP are mediated by specific cell surface receptors.…”

Section: Atrial Natriuretic Peptide (Anp)mentioning

confidence: 99%

Gonadal Peptides as Mediators of Development and Functional Control of the Testis: An Integrated System with Hormones and Local Environment

Gnessi¹

1997

Endocrine Reviews

168

145

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I. Introduction II. Neurohormones/Neuropeptides A. GH-releasing hormone (GHRH) B. Pituitary adenylate cyclase-activating peptide (PACAP) C. GnRH D. CRH E. Oxytocin (OT) F. Arginine vasopressin (AVP) G. TRH H. Somatostatin (SRIF) I. Opioids J. Substance-P (SP) K. Neuropeptide Y (NPY) III. Peptides Originally Identified in the Male Gonad A. Inhibin (INH) and activin (ACT) B. PModS IV. Growth Factors A. Insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBs) B. Transforming growth factor-␤ (TGF␤) C. TGF␣/EGF D. Fibroblast growth factor (FGF) E. Platelet-derived growth factor (PDGF) F. Nerve growth factor (NGF) G. Steel factor (SLF) H. Gastrin-releasing peptide (GRP) V. Immune Derived Cytokines A. Interleukins (ILs) B. Tumor necrosis factor-␣ (TNF␣) VI. Vasoactive Peptides A. Endothelin (ET) B. Angiotensin-II (AT-II) C. Atrial natriuretic peptide (ANP) VII. Conclusions and Perspectives

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Section: Atrial Natriuretic Peptide (Anp)mentioning

confidence: 99%

Gonadal Peptides as Mediators of Development and Functional Control of the Testis: An Integrated System with Hormones and Local Environment

Gnessi¹

1997

Endocrine Reviews

168

145

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“…Natriuretic peptide receptor, also known as guanylate cyclase A (GC-A), is a receptor bound on the cell surface of the plasma membrane that recognizes the ligand atrial natriuretic peptide receptor (ANP) 7 . The membrane-bound but not soluble form of GC-A/NPR1 is activated following binding of ANP to the cell surface 8 . The result of these events at the cell surface is the production of cyclic GMP.…”

Section: Discussionmentioning

confidence: 99%

The natriuretic peptide receptor, NPR1 is differentially expressed in non-small cell lung cancer and associates with patient survival.

Mamoor¹

2020

Preprint

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Non-small cell lung cancer (NSCLC) is the leading cause of cancer death in the United States (1). We mined published microarray data (2, 3, 4) to identify differentially expressed genes in NSCLC. We found that NPR1 was among the genes whose expression was most quantitatively different in tumors from patients with NSCLC as compared to the lung. NPR1 expression was significantly decreased in NSCLC tumors as compared to the lung, and lower expression of NPR1 in patient tumors was significantly associated with worse overall survival. NPR1 may be important for initiation or progression of non-small cell lung cancer in humans.

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“…It may be due t o the different ways in which the cell membrane is affected by the different treatments. In higher eukaryotes both inhibitory and stimulatory effects of Ca2+ on cGMP synthesis have been reported [Kimura and Murad, 1975;Lad and White, 1979;Europe-Finner and Newell, 1985;MacNeil, 1987;Klumpp et al, 1987;Koch and Stryer, 1988;Garbers, 1989Garbers, , 1994Garbers et al, 19941. It remains to be seen which of these in vitro effects of Ca2+ reflect physiologically relevant in vivo regulatory events.…”

Section: Open Circles (0) Represent the Ratio Of [3hllnsp3/mentioning

confidence: 99%

Guanylate cyclase activity in permeabilizedDictyostelium discoideum cells

et al. 1996

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Dictyostelium discoideum cells respond to chemoattractants by transient activation of guanylate cyclase. Cyclic GMP is a second messenger that transduces the chemotactic signal. We used an electropermeabilized cell system to investigate the regulation of guanylate cyclase. Enzyme activity in permeabilized cells was dependent on the presence of a nonhydrolysable GTP analogue (e.g., GTP gamma S), which could not be replaced by GTP, GDP, or GMP. After the initiation of the guanylate cyclase reaction in permeabilized cells only a short burst of activity is observed, because the enzyme is inactivated with a t1/2 of about 15 s. We show that inactivation is not due to lack of substrate, resealing of the pores in the cell membrane, product inhibition by cGMP, or intrinsic instability of the enzyme. Physiological concentrations of Ca2+ ions inhibited the enzyme (half-maximal effect at 0.3 microM), whereas InsP3 had no effect. Once inactivated, the enzyme could only be reactivated after homogenization of the permeabilized cells and removal of the soluble cell fraction. This suggests that a soluble factor is involved in an autonomous process that inactivates guanylate cyclase and is triggered only after the enzyme is activated. The initial rate of guanylate cyclase activity in permeabilized cells is similar to that in intact, chemotactically activated cells. Moreover, the rate of inactivation of the enzyme in permeabilized cells and that due to adaptation in vivo are about equal. This suggests that the activation and inactivation of guanylate cyclase observed in this permeabilized cell system is related to that of chemotactic activation and adaptation in intact cells.

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Guanylate Cyclase, a Cell Surface Receptor

Cited by 142 publications

References 78 publications

Gonadal Peptides as Mediators of Development and Functional Control of the Testis: An Integrated System with Hormones and Local Environment

Gonadal Peptides as Mediators of Development and Functional Control of the Testis: An Integrated System with Hormones and Local Environment

The natriuretic peptide receptor, NPR1 is differentially expressed in non-small cell lung cancer and associates with patient survival.

Guanylate cyclase activity in permeabilizedDictyostelium discoideum cells

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